CAS: 1008-76-0; 5-Phenyloxolan-2-One

相似化合物

36866-66-7 1318254-30-6 1885-28-5

上下游产品

styrene oxide ethanol sodium diethylmalonate α-bromoacetophenone4-hydroxy-4-phenyl-1-(piperidin-1-yl)butan-1-one N-cyclohexyl-4-hydroxy-4-phenylbutanamide 1-(4-methylphenyl)-5-phenylpyrrolidin-2-one 1,5-diphenylpyrrolidin-2-one

📜3-苯基环丁酮置于过氧化氢异丙苯,(R)-1,1'-Bi-2-Naphthol,二甲基氯化铝体系中,用 甲苯 用作溶剂,化学反应生成γ-苯基-γ-丁内酯
参考文献:铝催化不对称baeyer-Villiger反应中的配体效应
标题:铝催化不对称baeyer-Villiger反应中的配体效应
摘要:外消旋和手性环丁酮的不对称baeyer-Villiger氧化反应可以用基于铝的手性路易斯酸进行,从而产生具有高对映选择性的产品.通过使用取代的binol衍生物作为配体,获得了显着的催化剂效率,并获得了ee高达84%的γ-丁内酯.研发了配体的电子性质与反应的对映选择性之间的关系,从而使人们更好地理解了在铝催化的氧化转化中实现非常好对映选择性的要求.
Doi:10.1016/j.Tet.2005.12.080

专利信息

专利号:US-8598346-B2
优先权日:2008-07-16
标 题 :Synthesis of cyclic amidines
发明人：LENTZEN GEORG; NEUHAUS THORSTEN
权利人:LENTZEN GEORG; NEUHAUS THORSTEN; BITOP AG
摘要:The invention relates to an innovative method for synthesis of cyclic amidines. The synthesis starts from a β-, γ- or δ-lactone which is twofold brominated. After esterification of the carboxyl function, the bromine atoms are nucleophilically substituted and the corresponding diamino compound is obtained. The ring closure to the cyclic amidine is accomplished subsequently by reaction with orthoester, imidate or thioimidate. Owing to interposing additional steps for recovery of the diamino compound in enantiomerically pure form, the enantiomers of the cyclic amidines can be stereoselectively synthesized.

专利号:EP-2883866-A1
优先权日:2012-08-13
标题 :INTERMEDIATE FOR SYNTHESIS OF 1-(2-DEOXY-2-FLUORO-4-THIO-beta-D-ARABINOFURANOSYL) CYTOSINE, INTERMEDIATE FOR SYNTHESIS OF THIONUCLEOSIDE, AND METHODS FOR PRODUCING THESE INTERMEDIATES

专利号:WO-2014027658-A1
优先权日:2012-08-13
标题 :INTERMEDIATE FOR SYNTHESIS OF 1-(2-DEOXY-2-FLUORO-4-THIO-β-D-ARABINOFURANOSYL) CYTOSINE, INTERMEDIATE FOR SYNTHESIS OF THIONUCLEOSIDE, AND METHODS FOR PRODUCING THESE INTERMEDIATES

专利号:MX-2015001935-A
优先权日:2012-08-13
标 题 :INTERMEDIARY FOR SYNTHESIS OF 1- (2-DEOXI-2-FLUORO-4-TIO-BETA-D-A RABINOFURANOSIL) CITOSINE, INTERMEDIARY FOR SYNTHESIS OF TIONUCLEOSIDE AND METHODS TO PRODUCE THESE INTERMEDIARIES.

专利号:ES-2718307-T3
优先权日:2012-08-13
标题 :Intermediate for the synthesis of 1- (2-deoxy-2-fluoro-4-thio-beta-d-arabinofuranosyl) cytosine, intermediate for the synthesis of thionucleoside and methods to produce these intermediates

专利号:US-6028224-A
优先权日:1998-06-22
标 题 :Fluoxetine process from benzoylpropionic acid
发明人：HILBORN JAMES WALLACE; JURGENS ALEX ROGER; SENANAYAKE CHRIS HUGH
权利人:SEPRACOR INC
摘要:A synthesis of fluoxetine is disclosed. The process begins with a lower alkyl ester of 3-benzoylpropionic acid, which is reduced in the presence of a chiral ligand to produce the corresponding γ-hydroxy ester, and the ester is cleaved. The free acid is then condensed with the alcohol to form a γ-lactone, which is treated with ammonia to provide the γ-hydroxy amide. The amide undergoes a Hoffman rearrangement to provide a 2-oxo-1,3 oxazine, which is reduced to 3-(methylamino)-1-phenyl-1-propanol. The alcohol is deprotonated and reacted with a 4-chloro- or 4-fluoro benzotrifluoride to provide fluoxetine free base.