CAS: 97108-50-4; 2,5-Difluorophenylhydrazine

该化合物是一种氟化苯并二氮衍生物,通常用作有机合成的多用途中间体,特别是用于制作环环化合物和药品.氟化物替代物的存在增强了其在混合反应中的回动性和选择性,使其对构建复杂的分子框架很有价值.在标准条件下保持稳定,并符合各种反应协议,有助于其在药用化学和农用化学研究中的用途.该化合物的界定明确的结构和纯度确保了氟化染料,离子体和生物活性分子合成等应用的一贯性能.建议妥善处理,因为其潜在毒性和对湿度的敏感性.

英文名称2,5-Difluorophenylhydrazine
中文名称2,5-二氟苯肼
IUPAC名称(2,5-difluorophenyl)hydrazine
其它别名2,5-Difluorophenylhydrazine ; 2,5-Difluorophenylhydrazine; 2,5-Difluorophenylhydrazine; 2,5-Difluorophenylhydrazine,; 2,5-Difluorophenylhydrazine, 5Gr; 1,4-Difluoro-2-Hydrazinobenzene; Hydrazine, (2,5-Difluorophenyl)-
CAS编号97108-50-4
MFCD编号:MFCD00013384
EINECS号:627-334-5
分子式:C6H6F2N2
分子量:144.13
产品CID: 2020042
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
产品信息参考;
InChIKey: JNBRDOQHPXUXLY-UHFFFAOYSA-N
InChI=1S/C6H6F2N2/c7-4-1-2-5(8)6(3-4)10-9/h1-3,10H,9H2…
计算化学: 氢键受体数2.0氢键供体数2可旋转键数1

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别急性毒性类别4(吸入)
急性毒性类别4(经皮)
急性毒性类别4(经口)
特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2
警示词Warning(警告)
危险描述H332 |吸入有害.
H312 |皮肤接触有害.
H302 |吞咽有害.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
危险等级IRRITANT
UN编号NONH for all modes of transport
危险品标志Xn,Xi
安全声明26-36
危险类别码20/21/22-36/37/38
WGK Germany3

欧盟法规

ECHA物质C&L通报

上下游产品

2,5-difluoroaniline (Z)-1-(2,5-difluorophenyl)-2-(1,3-diphenylprop-2-yn-1-ylidene)hydrazine (S(S))-2',5'-difluoro-3,6-dimethoxy-2-p-tolylsulfinylazobenzene (S(S))-2',5'-difluorophenyl-3,6-dimethoxy-2-p-tolylsulfinylazobenzene

合成工艺路线路线简述

367-30-6 = 97108-50-4
反应条件:1.1 Reagents: Sodium Nitrite,Hydrochloric Acid Solvents: Water; 1 H,-5 °C1.2 Reagents: Hydrochloric Acid,Stannous Chloride Solvents: Water; -5 °C; 4 H,-5 °C1.3 Reagents: Sodium Hydroxide Solvents: Water; Ph 13
标题:Synthesis,Insecticidal Activities,And Structure-Activity Relationship Of Phenylpyrazole Derivatives Containing A Fluoro-Substituted Benzene Moiety
作者:Zhao,Yangyang; Gao,Li; Li,Huangong; Sun,Pengwei; Meng,Fanfei; Et Al
参考文献:Journal Of Agricultural And Food Chemistry 日期:2020 卷标:68(40) 页码:11282-11289]

367-30-6 = 97108-50-4
反应条件:1.1 Reagents: Sodium Nitrite,Hydrochloric Acid Solvents: Water1.2 Reagents: Stannous Chloride Solvents: Water
标题:From Blue To Red: Syntheses,Structures,Electronic,And Electroluminescent Properties Of Tunable Luminescent N,N Chelate Boron Complexes
作者:Liu,Qin-De; Mudadu,Maria S.; Thummel,Randolph; Tao,Ye; Wang,Suning
参考文献:Advanced Functional Materials 日期:2005 卷标:15(1) 页码:143-154]

367-30-6 = 97108-50-4
反应条件:1.1 Reagents: Sodium Nitrite,Hydrochloric Acid Solvents: Water; 0 °C; 1 H,0 °C1.2 Reagents: Hydrochloric Acid Catalysts: Stannous Chloride Solvents: Water; 0 °C; 2 H,Rt1.3 Reagents: Sodium Hydroxide Solvents: Water; Ph 7
标题:Synthesis And Biological Evaluation Of Benzimidazole Phenylhydrazone Derivatives As Antifungal Agents Against Phytopathogenic Fungi
作者:Wang,Xing; Chen,Yong-Fei; Yan,Wei; Cao,Ling-Ling; Ye,Yong-Hao
参考文献:Molecules 日期:2016 卷标:21(11)]

367-30-6 = 97108-50-4
反应条件:1.1 Reagents: Sodium Nitrite,Hydrochloric Acid Solvents: Water; 0 °C; 0.5 H,0 °C1.2 Reagents: Hydrochloric Acid,Stannous Chloride Solvents: Water; 0 °C; 2 H,0 °C
标题:Anthranilic Diamides Derivatives As Potential Ryanodine Receptor Modulators: Synthesis,Biological Evaluation And Structure Activity Relationship
作者:Liu,Jing-Bo; Li,Feng-Yun; Dong,Jing-Yue; Li,Yu-Xin; Zhang,Xiu-Lan; Et Al
参考文献:Bioorganic & Medicinal Chemistry 日期:2018 卷标:26(12) 页码:3541-3550]

367-30-6 = 97108-50-4
反应条件:1.1 Reagents: Sodium Nitrite,Hydrochloric Acid; 1 H,10 °C1.2 Reagents: Stannous Chloride Solvents: Water; 50 Min,10 °C
标题:Olefin Hydroarylation Catalyzed By (Pyridyl-Indolate)Pt(Ii) Complexes: Catalytic Efficiencies And Mechanistic Aspects
作者:Suslick,Benjamin A.; Liberman-Martin,Allegra L.; Wambach,Truman C.; Tilley,T. Don
参考文献:Acs Catalysis 日期:2017 卷标:7(7) 页码:4313-4322]

367-30-6 = 97108-50-4
反应条件:1.1 Reagents: Sodium Nitrite,Hydrochloric Acid,Stannous Chloride
标题:Application Of Haloindole-3-Acetic Acid As Herbicide
参考文献:China]

= 97108-50-4 [标题:Reaction Conditions
标题:Synthesis And Resolution Of 7-Fluorotryptophans
作者:Lee,Minsu; Phillips,Robert S.
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:1991 卷标:1(9) 页码:477-80

2,5-二氟苯胺置于盐酸,Sodium Nitrite,Tin(Ll) Chloride体系中,化学反应 2.5H,以69.9%的收率获得产物2,5-二氟苯肼
参考文献:邻氨基苯甲酰胺衍生物作为潜在的ryanodine受体调节剂:合成,生物学评估和结构活性关系.
标题:邻氨基苯甲酰胺衍生物作为潜在的ryanodine受体调节剂:合成,生物学评估和结构活性关系.
摘要:设计,合成了一系列含有卤素,三氟甲基和氰基的新型邻氨基苯甲酰胺衍生物(7A-s),并通过熔点,1 H NMR,13 C NMR和元素分析对其进行了表征.生物活性表明,它们中的大多数对东方粘虫(mythimna Separata)和小菜蛾(plutella Xylostella)表现出中等至优异的活性.首先,的杀幼虫活性70对粘虫率为100%,为0.25的40%和0.1毫克的l-1,比得上标准氯虫苯甲酰胺(100%,0.25毫克的l的-1和20%,0.1毫克的l-1).更,对抗小菜蛾的7O在0.01 Mg L-1时显示出90%的杀虫活性,优于四氯苯丙胺(45%,0.01 Mg L-1).将美国蟑螂(periplaneta Americana)心脏跳动率(背血管)和收缩力的实验7O与绿头兰醇进行了比较.此外,7O可能会影响东方粘虫第三幼虫中枢神经元的钙稳态,这表明,Ryanodine
DOI:10.1016/j.Bmc.2018.05.028

专利信息

专利号:US-8030311-B2
优先权日:2005-04-14
标题:Phenylacetamides suitable as protein kinase inhibitors
发明人：BOLD GUIDO; FURET PASCAL; GUAGNANO VITO; MCCARTHY CLIVE; VAUPEL ANDREA
权利人:NOVARTIS AG
摘要:The invention relates to compounds of the formula (I) wherein the moieties R1, R2, R3, R9, R10 and Q and X, Y and Z are as defined in the specification, and salts thereof, as well as their use, methods of use for them and method of their synthesis, and the like. The compounds are protein kinase inhibitors and can, inter alia, be used in the treatment of various proliferative diseases.

专利号:CN-107793362-A
优先权日:2016-08-30
标题:Synthesis and application of a kind of phenylpyridazinone derivatives

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优先权日:2016-07-27
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