CAS: 953769-46-5; 4-((2-(((1R,2R)-2-Hydroxycyclohexyl)Amino)Benzo[d]Thiazol-6-yl)Oxy)-N-Methylpicolinamide

上下游产品

4-(2-Methanesulfinyl-Benzothiazol-6-Yloxy)-Pyridine-2-Carboxylic Acid Methylamide 953770-87-1

📜2-氯-6-甲氧基苯并噻唑置于三溴化硼,Potassium Carbonate,三乙胺体系中,用 四氢呋喃,N-甲基吡咯烷酮,二氯甲烷,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 83.0H,反应生成 化合物blz945
参考文献:Blz945 Derivatives For Pet Imaging Of Colony Stimulating Factor-1 Receptors In The Brain
标题:Blz945 Derivatives For Pet Imaging Of Colony Stimulating Factor-1 Receptors In The Brain
摘要:
DOI:10.1016/j.Nucmedbio.2021.06.005

专利信息

专利号:US-2024066133-A1
优先权日:2020-03-06
标 题 :Therapeutic agents and conjugates thereof
发明人：SONG YUNTAO; LI ANRONG; LI HUI; LI XIANFENG; YANG JUNBAO
权利人:BEIJING XUANYI PHARMASCIENCES CO LTD
摘要:The present disclosure provides a class of conjugates of general formula (X), a class of TLR9 agonist derivatives, such as formula (I), (XX), and (XXI), certain diastereomers of STING agonists, a class of STING agonist derivatives, such as formula (XXVIV), a class of heterocyclic compounds of general formula (II), a class of heterocyclic compounds of general formula (III), as defined herein. A 1 , A 2 , T, Z 1 , Z 2 , Z 3 , b 1 , and b 2 , in formula (X) are defined herein. The conjugate provides unique properties that are based upon the properties of the therapeutic agents that are part of the conjugate. Also provided are methods of synthesis and use of compounds.

专利号:US-2022259202-A1
优先权日:2019-06-17
标题:1-(4-(aminomethyl)benzyl)-2-butyl-2h-pyrazolo[3,4-c]quinolin-4-amine derivatives and related compounds as toll-like receptor (tlr) 7/8 agonists, as well as antibody drug conjugates thereof for use in cancer therapy and diagnosis
发明人：MEIMETIS LABROS
权利人:SUTRO BIOPHARMA INC
摘要:1-(4-(aminomethyl)benzyl)-2-butyl-2H-pyrazolo[3,4-c]quinolin-4-amine derivatives thereof and related compounds of formula (I) as toll-like receptor (TLR) 7/8 agonists for cancer therapy. Linker payload compounds thereof, and antibody conjugates thereof for cancer diagnosis. The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 145 to 156; examples 1 to 3; biological examples 1 to 6; tables 1 and 2).