CAS: 89466-59-1; 2-Chloro-4-Methyl-6-(Methylthio)Pyrimidine

该化合物是一种多用途的七环环化合物,其特点是2位置的氯替代物和6位置的甲基磺酰胺组,加强了其在核细胞替代反应中的活性.这种丙酰衍生物是合成农用化学品,药品和特殊化学品的宝贵中间体.其结构框架允许进一步功能化,使其有助于开发作物保护和医药应用活性成分.该化合物的稳定性和明确界定的再活动特征有助于其在有机合成中的用途,通常在标准实验室条件下处理,对其含氯和含硫的功能组给予适当的防范.

结构式图片

相似化合物

49844-93-1 62671-89-0 213334-25-9

上下游产品

CAS号16710-11-5 4-甲基-6-(甲基硫代)嘧啶-2-醇

合成工艺路线路线简述

  • 合成目标产物 2-Chloro-4-Methyl-6-Methylsulfanyl-Pyrimidine 主要起始原料 2,4-Dichloro-6-Methylpyrimidine And Sodium Thiomethoxide
  • 5188-07-8 + 5424-21-5 = 89466-59-1
    反应条件:1.1 Solvents: Tetrahydrofuran,Water; 0 °C; 2 H,0 °C1.2 Solvents: Water; 0 °C
    标题:Regioselective 2-Amination Of Polychloropyrimidines
    作者:Smith,Sean M.; Buchwald,Stephen L.
    参考文献:Organic Letters 日期:2016 卷标:18(9) 页码:2180-2183]

    6328-58-1 = 89466-59-1
    反应条件:1.1 6 Min
    标题:Ultrasound-Assisted Green Syntheses Of Novel Pyrimidine Derivatives And Their Comparison With Conventional Methods
    作者:Pivazyan,Vergush A.; Ghazaryan,Emma A.; Karapetyan,Armen V.; Shainova,Roza S.; Harutyunyan,Siranush V.; Et Al
    参考文献:Beilstein Archives 日期:2022 卷标:1 页码:1-12
📜4-甲基-6-(甲基硫代)嘧啶-2-醇置于三氯氧磷体系中,化学反应生成 2-氯-4-甲基-6-甲硫基嘧啶
参考文献:De839640
标题:De839640

海关参考信息

专利信息


专利号:US-7576245-B2
优先权日:2002-07-11
标题:Fluorous tagging and scavenging reactants and methods of synthesis and use thereof
发明人:ZHANG WEI; LUO ZHIYONG
权利人:FLUOROUS TECHNOLOGIES INC
摘要:The present invention includes methods and compositions for increasing the fluorous nature of an organic compound by reacting it with at least one fluorous compound to produce a fluorous tagged organic compound. The increased fluorous nature of the fluorous tagged organic compound can then be utilized to separate the fluorous organic compound from untagged reagents, reactants, catalysts and/or products derived therefrom. The resultant fluorous tagged organic compound can be subjected to subsequent chemical transformations, wherein the fluorous nature of the tagged compound is utilized to increase the ease of separation of the fluorous tagged organic compound from untagged reagents, reactants, catalysts and/or products derived therefrom, after each chemical transformation. The chemical transformations result in a second fluorous tagged organic compound wherein the fluorous nature of the second fluorous tagged organic compound can then be reduced by removing the fluorous group therefrom, thereby producing a second organic compound that may be employed as a pharmaceutical compound or intermediate, or a combinatorial library component.

专利号:US-2004073054-A1
优先权日:2002-07-11
标 题 :New fluorous tagging and scavenging reactants and methods of synthesis and use thereof

专利号:US-2006128957-A1
优先权日:2002-07-11
标题:Fluorous tagging and scavenging reactants and methods of synthesis and use thereof

专利号:US-7060850-B2
优先权日:2002-07-11
标 题 :Fluorous tagging and scavenging reactants and methods of synthesis and use thereof

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合成参考文献


摘要:Kleemann, A.; Engel, J.; Kutscher, B.; Reichert, D., Pharmaceutical Substances[Online], Thieme: Stuttgart, (2021)
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