CAS: 85068-29-7; (3,5-Bis(Trifluoromethyl)Phenyl)Methanamine

上下游产品

CAS号401-95-6 3,5-双(三氟甲基)苯甲醛 | CAS号511256-30-7 N-benzyl-1-(3,5... | CAS号27126-93-8 3,5-双(三氟甲基)苯甲腈 | CAS号676557-17-8 N-[3,5-Bis(trif...

3,5-双三氟甲基苯甲醛置于magnesium Sulfate,1,8-二氮杂双环[5.4.0]十一碳-7-烯,Potassium 2-Amino-2-Phenylpropanoate体系中,用 1,4-二氧六环 作为反应溶剂,以54 %的收率获得产物3,5-双(三氟甲基)苄胺
参考文献:芳香醛与伯芳基甲胺的转氨作用
标题:芳香醛与伯芳基甲胺的转氨作用
摘要:在 2-氨基-2-苯基丙酸盐(2A或2E)作为胺源存在的情况下,芳香醛在非常温和的条件下进行脱羧氨基转移,以 44-99% 的收率生产各种芳基甲胺.该工作为伯芳基甲胺的合成提供了一种高效的新方法.
DOI:10.1021/acs.Orglett.3C01234

专利信息

专利号:US-5877278-A
优先权日:1992-09-24
标题:Synthesis of N-substituted oligomers
发明人：ZUCKERMANN RONALD N; GOFF DANE A; NG SIMON; SPEAR KERRY; SCOTT BARBARA O; SIGMUND AARON C; GOLDSMITH RICHARD A; MARLOWE CHARLES K; PEI YAZHONG; RICHTER LUTZ; SIMON REYNA
权利人:CHIRON CORP
摘要:A solid-phase method for the synthesis of N-substituted oligomers, such as poly (N-substituted glycines) (referred to herein as poly NSGs) is used to obtain oligomers, such as poly NSGs of potential therapeutic interest which poly NSGs can have a wide variety of side-chain substituents. Each N-substituted glycine monomer is assembled from two 'sub-monomers' directly on the solid support. Each cycle of monomer addition consists of two steps: (1) acylation of a secondary amine bound to the support with an acylating agent comprising a leaving group capable of nucleophilic displacement by -NH2, such as a haloacetic acid, and (2) introduction of the side-chain by nucleophilic displacement of the leaving group, such as halogen (as a solid support-bound alpha -haloacetamide) with a sufficient amount of a second sub-monomer comprising an -NH2 group, such as a primary amine, alkoxyamine, semicarbazide, acyl hydrazide, carbazate or the like. Repetition of the two step cycle of acylation and displacement gives the desired oligomers. The efficient synthesis of a wide variety of oligomeric NSGs using automated synthesis technology of the present method makes these oligomers attractive candidates for the generation and rapid screening of diverse peptidomimetic libraries. The oligomers of the invention, such as N-substituted glycines (i.e. poly NSGs) disclosed here provide a new class of peptide-like compounds not found in nature, but which are synthetically accessible and have been shown to possess significant biological activity and proteolytic stability. Combinatorial libraries of cyclic compounds are disclosed wherein the cyclic compounds are comprised of at least one ring structure derived from cyclization of a peptoid backbone. The diversity of product compounds is generated by the sequential addition of substituted submonomers. The combinatorial library includes 10 or more, preferably 100 or more, and more preferably 1,000 or more distinct and different compounds. The library includes each of the product compounds in retrievable and analyzable amounts and preferably includes at least one biologically active compound. Methods of synthesizing the combinatorial libraries and assay devices produced using the libraries are disclosed as is methodology for screening for and obtaining biologically active cyclic organic compounds.

专利号:US-2025049791-A1
优先权日:2023-08-03
标题:Synthesis of MEK7 Inhibitors and methods of Use Thereof
发明人：SCHEIDT KARL A; KIM DALTON ROBERT; ORR MEGHAN JO
权利人:UNIV NORTHWESTERN
摘要:Disclosed herein are 4-phenoxypyrimidine compounds and derivatives thereof for use as inhibitors of mitogen-activated protein kinase 7 (MEK7). The disclosed compounds and pharmaceutical compositions thereof may be used in methods for treating a disease or disorder associated with MEK7 activity, including cell proliferative diseases and disorders associated with MEK7 activity, such as cancer.

专利号:EP-0789577-A1
优先权日:1995-06-07
标 题:Synthesis of n-substituted oligomers

专利号:EP-0789577-B1
优先权日:1995-06-07
标 题:Synthesis of n-substituted oligomers

专利号:WO-9931506-A1
优先权日:1997-12-18
标题 :Parallel solution phase synthesis of lactams

专利号:WO-9640202-A1
优先权日:1995-06-07
标 题:Synthesis of n-substituted oligomers