CAS: 73842-99-6; 3-((Tert-Butyldimethylsilyl)Oxy)Propan-1-Ol

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CAS号18162-48-6 叔丁基二甲基氯硅烷 | CAS号504-63-2 1,3-丙二醇 | CAS号203738-77-6 3-tert-butyldim... | CAS号1178887-86-9 tert-butyl(3-(4... | CAS号1071936-49-6 (S,Z)-2-fluoro-... | CAS号78878-05-4 叔丁基(3-碘丙氧基)二甲基硅烷 | CAS号288-32-4 咪唑 | CAS号102191-92-4 叔丁基二甲基硅氧烷基乙醛 | CAS号89031-84-5 3-溴丙基叔丁基二甲基硅醚 | CAS号89922-82-7 3-(叔丁基二甲基硅氧基)丙醛 | CAS号158112-46-0 5-[tert-butyl(d... | CAS号263900-32-9 (+)-METHYL (3S)... | CAS号118635-66-8 2-Pentenal, 5-[... | CAS号114778-46-0 3-氨基-N-(二甲基叔丁基甲... | CAS号120821-21-8 3-[tert-butyl(d... | CAS号187527-25-9 (5S)-5,7-Bis-{[... | CAS号78878-05-4 叔丁基(3-碘丙氧基)二甲基硅烷 | CAS号86462-75-1 (E)-5-(叔丁基二甲基硅氧...

叔丁基二甲基甲硅烷基缩水甘油醚置于ammonia Borane,C28H28Cl2Conp2,Erbium(Iii) Triflate体系中,用 四氢呋喃 作为反应溶剂,化学反应 8.0H,以63%的收率获得产物3-(叔丁基二甲基硅氧)丙醇
参考文献:轻度条件下由ization催化的区域选择性异构化-钴催化的转移加氢序列从环氧化合物合成抗马尔科夫尼科夫醇
标题:轻度条件下由ization催化的区域选择性异构化-钴催化的转移加氢序列从环氧化合物合成抗马尔科夫尼科夫醇
摘要:本文中,我们报告了一种基于钴夹钳催化剂(1 Mol%)的高效异构化转移加氢反应序列,该序列可在温和的反应条件下(<=55oc)由末端和内部环氧化物合成一系列抗马尔可夫尼可夫醇,8 H)在低催化剂负载下.反应通过路易斯酸(3摩尔%er(otf)3)催化的环氧化物异构化,然后使用氨硼烷作为氢源进行钴催化的转移氢化.由环氧化物合成43种醇突出了这种方法的一般适用性.带有不同官能团的各种端基(23个实例)和1,2-二取代的内部环氧化物(14个实例)以优异的选择性和高达98%的产率转化为所需的抗马尔可夫尼可夫醇.对于选定的实施例,表明反应可以以高达50Mmol的制备规模进行.值得注意的是,异构化步骤是通过最稳定的碳阳离子进行的.因此,区域化学受立体电子效应控制.结果,在某些情况下,当三和四取代的环氧化物(6个实例)被转化时,观测到碳骨架的重排.即使在反应条件下醛和酮也被还原成相应的醇,在反应条件下仍能
DOI:10.1021/acscatal.0C03294

专利信息

专利号:US-11912647-B2
优先权日:2020-05-22
标 题:Diversity-oriented synthesis of N,N,O-trisubstituted hydroxylamines from alcohols and amines by N—O bond formation
发明人：CRICH DAVID; HETTIKANKANAMALAGE ASIRI; HILL JARVIS
权利人:UNIV GEORGIA
摘要:In one aspect, the disclosure relates to a method for the direct synthesis of complex N,N,O-trisubstituted hydroxylamines by N—O bond formation. In another aspect, the method can successfully be employed using a wide variety of commercially available alcohols and secondary amines and enables the construction of large fragment-based libraries of trisubstituted hydroxylamines for drug discovery purposes. Also disclosed are N,N,O-trisubstituted hydroxylamines having low basicity, high stability at ambient temperatures, and an inherent lack of reactivity towards acetylating and sulfonylating enzymes that confer mutagenicity on less-substituted hydroxylamines.

专利号:US-6262251-B1
优先权日:1995-10-19
标题 :Method for solution phase synthesis of oligonucleotides
发明人：PIEKEN WOLFGANG; MCGEE DANNY; SETTLE ALECIA; ZHAI YANSHENG; HUANG JIANPING
权利人:PROLIGO LLC
摘要:This invention discloses an improved method for the sequential solution phase synthesis of oligonucleotides. The method lends itself to automation and is ideally suited for large scale manufacture of oligonucleotides with high efficiency.

专利号:WO-9847910-A1
优先权日:1997-04-21
标题:Method for solution phase synthesis of oligonucleotides
发明人：PIEKEN WOLFGANG; MCGEE DANNY; SETTLE ALECIA; ZHAI YANSHENG; HUANG JIANPING; HILL KEN; SMITH RANDALL S
权利人:NEXSTAR PHARMACEUTICALS INC; PIEKEN WOLFGANG; MCGEE DANNY; SETTLE ALECIA; ZHAI YANSHENG; HUANG JIANPING; HILL KEN; SMITH RANDALL S
摘要:This invention discloses an improved method for the sequential solution phase synthesis of oligonucleotides. The method lends itself to automation and is ideally suited for large scale manufacture oligonucleotides with high efficiency.

专利号:US-5874532-A
优先权日:1997-01-08
标 题 :Method for solution phase synthesis of oligonucleotides and peptides
发明人：PIEKEN WOLFGANG; GOLD LARRY
权利人:NEXSTAR PHARMACEUTICALS INC
摘要:This invention discloses an improved method for the sequential solution phase synthesis of oligonucleotides and peptides. The method lends itself to automation and is ideally suited for large scale manufacture oligonucleotides with high efficiency.

专利号:US-6001966-A
优先权日:1995-10-19
标题 :Method for solution phase synthesis of oligonucleotides and peptides
发明人：PIEKEN WOLFGANG; GOLD LARRY
权利人:PROLIGO LLC
摘要:This invention discloses an improved method for the sequential solution phase synthesis of oligonucleotides and peptides. The method lends itself to automation and is ideally suited for large scale manufacture oligonucleotides with high efficiency.

专利号:WO-2024216794-A1
优先权日:2023-04-17
标 题:Implantable material and synthesis method therefor and prosthetic heart valve
发明人：WANG LICHAO; WEI XING; KUANG DAJUN
权利人:VENUS MEDTECH HANGZHOU INC
摘要:The present application discloses an implantable material and a synthesis method therefor and a prosthetic heart valve. The implantable material uses polyurethane, the molecular chain structure of polyurethane comprises a soft segment and a hard segment, and a functional branched chain is grafted onto the hard segment; the solubility parameter of the functional branched chain is 6-8. According to the present application, by introducing the functional branched chain into the hard segment, the compatibility between the hard segment and the soft segment is improved and the stress transfer points between the hard segment and the soft segment are increased, so that the prepared implantable polymer material has excellent mechanical properties.