CAS: 59944-76-2; Thieno[2,3-B]Pyridine-2-Carboxylic Acid

相似化合物

154650-88-1 59944-78-4 53174-98-4

上下游产品

CAS号154650-88-1 噻吩并[2,3-b]吡啶-2-羧酸甲酯 | CAS号59944-78-4 噻吩并[2,3-b]吡啶-2-羧酸乙酯 | CAS号52505-46-1 3-氨基噻吩并[2,3-b]吡... | CAS号36404-88-3 2-氯-3-吡啶甲醛 | CAS号272-23-1 噻吩并[2,3-b]吡啶

📜2-氯-3-吡啶甲醛置于水,三乙胺,Sodium Hydroxide体系中,用 甲醇,乙腈 作为反应溶剂,化学反应 23.0H,反应生成 噻吩并[2,3-B]吡啶-2-甲酸
参考文献:Sulfonamides As Trpm8 Modulators
标题:Sulfonamides As Trpm8 Modulators
摘要:揭示了用于治疗各种疾病,综合征,症状和疾病的化合物,组合物和方法,包括疼痛.这些化合物由以下的化学式i所代表:其中a,B,G,Y,R1,R2,R3和r4在此处被定义.

专利信息

专利号:US-2016200733-A1
优先权日:2013-08-23
标 题 :Substituted thieno[2,3-b]pyridine-2-carboxamide analogs as positive allosteric modulators of the muscarinic acetylcholine receptor m4
发明人：LINDSLEY CRAIG W; CONN P JEFFREY; WOOD MICHAEL R; POSLUSNEY MICHAEL S; MELANCON BRUCE J
权利人:UNIV VANDERBILT
摘要:In one aspect, the invention relates to substituted thieno[2,3-b]pyridine-2-carboxamide analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M 4 (mAChR M 4 ); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.