CAS: 59920-31-9; α-Glu

该化合物是属于非伊诺糖类的合成化合物,其特点是存在氢氧基和非伊诺功能组,这对其独特的化学特性有帮助;该化合物是D-manitol的衍生物,一种糖酒精,并具有结构性特征,使其可能成为甘蓝的抑制剂,酶在碳水化合物代谢中发挥关键作用;伊米诺集团在结构中引入氮原子,可影响其生物活动和溶性;2,5-甲氧基-2,5-免疫-D-曼尼托醇对医药化学感兴趣,因为它可能被用于治疗与淋病和糖尿病有关的疾病;其稳定性,再活性和粘合性使该物质成为生物化学和药理学研究的宝贵化合物;然而,对其药理学和毒性进行详细研究对于了解其治疗潜力至关重要.

英文名称α-Glu
中文名称α-葡萄糖苷酶
IUPAC名称(2R,3R,4R,5R)-2,5-bis(hydroxymethyl)pyrrolidine-3,4-diol
其它别名2R,5R-Bis(Hydroxymethyl)-3R,4R-Dihydroxypyrrolidine; 2,5-Dideoxy-2,5-Imino-D-Mannitol; Dmdp; 2,5-Dihydroxymethyl-3,4-Dihydroxypyrrolidine; (2R,5R)-Bis(Hydorxymethyl)-(3R,4R)-*dihydroxypyrr; (2R,5R)-Bis(Hydorxymethyl)-(3R,4R)-*dihy Droxypyrrol; 2,5-Pyrrolidinedimethanol, 3,4-Dihydroxy-, (2R,3R,4R,5R)-; 2,5-Dideoxy-2,5-Imino-L-Mannitol
CAS编号59920-31-9
EINECS号:633-130-7
分子式:C6H13NO4
分子量:163.17
产品CID: 1576176
产品分类生物化工 → 糖类化合物 → 单糖

相似结构搜索
产品信息参考;;;;
InChIKey: PFYHYHZGDNWFIF-KVTDHHQDSA-N
InChI=1S/C6H13NO4/c8-1-3-5(10)6(11)4(2-9)7-3/h3-11H,1-2H2/t3-,4-,5-,6-/m1/s1…
计算化学: 氢键受体数5.0氢键供体数5.0可旋转键数2.0

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2
警示词Warning(警告)
危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P264Thoroughly clean after treatmentP280Wear protective gloves/Wear protective clothing/Wear protective goggles/Wear a protective maskP305If it enters the eyesP351Rinse carefully with water for a few minutesP338Remove the contact lens(If any)And easy to operate,Continue flushingP337If eye irritation persistsP313Obtain medical advice/care
危险品标志Xi
安全声明26-36
危险类别码R36/37/38
WGK Germany3

欧盟法规

ECHA物质C&L通报

上下游产品

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合成工艺路线路线简述

5-酮果糖置于palladium Dihydroxide 氢气,Sodium Cyanoborohydride,溶剂黄146体系中,用甲醇作为反应溶剂,化学反应 6.0H,反应生成 Alpha-葡萄糖苷酶
参考文献:Expeditious Synthesis Of Aza Sugars By The Double Reductive Amination Of Dicarbonyl Sugars
标题:Expeditious Synthesis Of Aza Sugars By The Double Reductive Amination Of Dicarbonyl Sugars
摘要:Polyhydroxylated Pyrrolidines And Piperidines Were Prepared By The Double Reductive Amination Of Dicarbonyl,Sugars With Primary Amines And Nacnbh3 In Meoh. Stereocontrol In These Reactions Depended On The Nature Of The Amine And Dicarbonyl Sugar. For Example,5-Keto-D-Fructose (7) Gave Three Pyrrolidine Stereoisomers,With The N-Alkylated 2,5-Anhydro-2,5-Imino-D-Glucitol Predominating. Under Similar Reaction Conditions With Benzhydrylamine,5-Keto-D-Glucose (20) Afforded A 96:4 Mixture Of Piperidines Favoring D-Gluco 25A,Whereas 5-Keto-D-Mannose (6) Produced A 67:33 Mixture Enriched In D-Manno Isomer 40. This Method Allowed For The Direct And Relatively Short Synthesis Of 1-Deoxynojirimycin (Dnj,1) And 1-Deoxymannojirimycin (Dmj,5) And N-Alkylated Derivatives Thereof. Similar Reactions With O-Protected 5-Keto-D-Glucose Derivatives 21 And 22 Were Less Stereoselective And Lower Yielding.
DOI:10.1021/jo00090A040