CAS: 56183-63-2; Bis(Diisopropylamino)Chlorophosphine

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CAS号108-18-9 二异丙胺 | CAS号113533-22-5 C-[Bis(diisopro... | CAS号921-26-6 二氯-N,N-二异丙基亚磷酰胺 | CAS号80907-47-7 {NEt4}{HW(CO)5} | CAS号109065-32-9 (chloro)diazome... | CAS号92611-10-4 N,N,N',N'-四异丙基亚... | CAS号98796-51-1 DMT-dT亚磷酰胺单体 | CAS号108-18-9 二异丙胺 | CAS号102691-36-1 双(二异丙基氨基)(2-氰基乙氧基)膦 | CAS号86660-77-7 Phosphonous dia... | CAS号3332-08-9 N-(异丙亚胺基)异丙胺 | CAS号137348-88-0 叔丁基四异丙基磷酸二阿米迪特 | CAS号122194-07-4 N,N-二异丙基亚磷酰胺二甲基 | CAS号68880-43-3 BIS(DIISOPROPYL... | CAS号59758-27-9 hexamethylphosp...

二异丙胺置于三氯化磷体系中,用 甲苯 作为反应溶剂,以83 %的收率获得产物双二异丙基氨基氯化磷
参考文献:对 S,S-双叶立德反应性的新见解
标题:对 S,S-双叶立德反应性的新见解
摘要:目前的工作重点是 S,S-双叶立德 2 的反应性,它具有很强的亲核特性,与碘甲烷和 Co2 的反应证明了这一点,分别提供了 C-甲基化盐 3 和甜菜碱 4.甜菜碱 4 的衍生化得到相应的酯衍生物 6,其通过使用 NMR 光谱和 X 射线衍射分析得到充分表征.此外,与磷离子的初始反应导致瞬时推拉膦基(磺基)卡宾 8 的形成,它会重排反应生成稳定的锍叶立德衍生物 7.
DOI:10.3390/molecules28083295

专利信息

专利号:US-11938187-B2
优先权日:2021-06-10
标题:Methods and compositions for synthesis of two-photon cleavable phosphoramidite molecules for oligonucleotide conjugation
发明人：LO PEGGY PIK KWAN; LIU LING SUM; TAM DICK YAN
权利人:UNIV CITY HONG KONG
摘要:The syntheses of two phosphoramidite building blocks based on BNSF and BNSMB structures are disclosed. Furthermore, some common molecular intermediates have been designed and linked to the central biphenyl core of the two molecules, resulting in a versatile and cost-effective design. These compounds can be effectively introduced to DNA oligonucleotides via the well-established standard cyanoethylphosphoramidite chemistry on the nucleic acid synthesizer. Fragmentation of these BNSF- and BNSMB-functionalized DNA strands is achieved by both one-photon and two-photon photolysis of photoliable bonds of [2-(2-nitrophenyl)propoxy]carbonyl groups on BNSF and BNSMB molecules respectively, resulting in two short pieces of single-stranded DNAs. The versatile design and facile synthesis of these two-photon photocleavage phosphoramidite molecules are beneficial to synthetic chemists and photochemists for the development of new caged compounds which enables to introduce into oligonucleotides as light-triggered carriers via solid-phase synthesis for a wide range of applications in materials science, polymer, chemistry, biology and DNA nanoecthnology.

专利号:US-8183355-B2
优先权日:2006-04-28
标题 :Method for the synthesis of oligonucleotide derivatives
发明人：MORVAN FRANCOIS; MEYER ALBERT; VASSEUR JEAN-JACQUES; VIDAL SEBASTIEN; CLOAREC JEAN-PIERRE; CHEVOLOT YANN; SOUTEYRAND ELIANE
权利人:MORVAN FRANCOIS; MEYER ALBERT; VASSEUR JEAN-JACQUES; VIDAL SEBASTIEN; CLOAREC JEAN-PIERRE; CHEVOLOT YANN; SOUTEYRAND ELIANE; CENTRE NAT RECH SCIENT
摘要:Method for the synthesis of nucleotide derivatives wherein molecules of interest are grafted on the oligonucleotide with the help of a “click chemistryâ€? reaction between an azide function on the molecule of interest and an alkyne function on the oligonucleotide, or between an alkyne function on the molecule of interest and an azide function on the oligonucleotide. n Intermediate molecules, notably alkyne functionalized oligonucleotides, grafted oligonucleotides, azide functionalized oligonucleotides, oligonucleotide micro arrays containing them and the use of those grafted oligonucleotides for biological investigation and for cell targeting.

专利号:US-11518780-B2
优先权日:2019-07-31
标 题:Sensitive oligonucleotide synthesis using sulfur-based functions as protecting groups and linkers
发明人：FANG SHIYUE
权利人:FANG SHIYUE
摘要:Embodiments for the synthesis of sensitive oligonucleotides as well as insensitive oligonucleotides are provided. Sulfur-based groups are used for the protection of exo-amino groups of nucleobases, phosphate groups and 2′—OH groups, and as cleavable linker for linking oligonucleotides to a support. Oligonucleotide syntheses are achieved under typical conditions using phosphoramidite chemistry with important modifications. To prevent replacing sulfur-based protecting groups by acyl groups via cap-exchange, special capping agents are used. To retain hydrophobic tag to assist RP HPLC purification, special phosphoramidites are used in the last synthetic cycle. With the sulfur-based groups for protection and linking, oligonucleotide deprotection and cleavage are achieved via oxidation followed by beta-elimination under mild conditions. Therefore, besides for insensitive oligonucleotide synthesis, the embodiments of the invention are capable for the synthesis of oligonucleotide analogs containing sensitive functional groups that cannot survive the harsh conditions used in prior art oligonucleotide synthesis technologies.

专利号:US-11584773-B2
优先权日:2014-04-30
标 题:Phosphorous protecting groups and methods of preparation and use thereof
发明人：DELLINGER DOUGLAS J; MONFREGOLA LUCA; CARUTHERS MARVIN; ROY MITHUN
权利人:AGILENT TECHNOLOGIES INC
摘要:Aspects of the present disclosure include compositions that make use of phosphorus and/or nucleobase protecting groups which find use in the synthesis of long polynucleotides. Phosphorus protecting groups are provided that help increase the stepwise coupling yield and/or phosphorous protecting groups that can be removed during the oxidation step. Amidine nucleobase protecting groups are provided that find use in the subject compositions and methods which provides for e.g., increased resistance to depurination during polynucleotide synthesis. In some instances, the methods and compositions disclosed herein utilize a combination of the phosphorus and amidine nucleobase protecting groups in the synthesis of polynucleotides having a sequence of 200 or more monomeric units in length. Also provided are methods for synthesizing a polynucleotide (e.g., a DNA) using one or more compounds disclosed herein.

专利号:US-5902878-A
优先权日:1989-05-24
标 题 :Modified phosphoramidite process for the production of modified nucleic acids
发明人：SELIGER HEINZ-HARTMUT; BERNER SIBYLLE; MUEHLEGGER KLAUS; VON DER ELTZ HERBERT; BATZ HANS-GEORG
权利人:BOEHRINGER MANNHEIM GMBH
摘要:The subject matter of the invention is a modified phosphoramidite process for the synthesis of nucleotide sequences. By use of a modified nucleoside phosphoramidite it is possible to produce nucleotide sequences which have a modified phosphate residue.

专利号:US-12291489-B2
优先权日:2016-07-01
标 题 :Synthesis of nanocomposites and their use in enhancing plant nutrition
发明人：BISWAS PRATIM; RALIYA RAMESH
权利人:BISWAS PRATIM; RALIYA RAMESH; WASHINGTON UNIVERSITY ST LOUIS
摘要:The present disclosure is related to the development of improved fertilizer for precision and sustainable agriculture. A method was developed wherein efficient NPK nanocomposite for plant nutrition was synthesized in a single step using aerosol science and technology concepts. Further a formulation was prepared by addition of ZnO, TiO 2 and other nanoparticles to the NPK nanocomposite. Also, an aerosol based foliar application technique was developed for the precise delivery of nanoparticles to the plants.