CAS: 483-04-5; Raubasine

该化合物是来自Genus Ravolfia植物物种,特别是Rauvolfia 蛇体植物品种的碱,其特点是其复杂的蛋白结构,有助于其药理特性.Ajmalicine展示了一系列生物活动,包括防血压和镇静作用,使其对药用化学感兴趣.该化合物主要作为外围血管喷气器,并研究其在治疗高血压和其他心血管病方面的潜力.Ajmalicine的行动机制包括抑制某些...

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CAS号67-56-1 甲醇 | CAS号5815-08-7 叔丁氧基双(二甲胺基)甲烷 | CAS号483-03-4 3-Isoajmalicine | CAS号19351-63-4 断马钱子苷

合成工艺路线路线简述

    📜3-Dehydroajmalicine Perchlorate置于三正丁基氢锡体系中,用 甲醇 作为反应溶剂,化学反应 0.08H,以90%的收率获得产物萝巴新
    参考文献:A Mild And Chemoselective Reduction Of Cyclic Iminium Salts
    标题:A Mild And Chemoselective Reduction Of Cyclic Iminium Salts
    摘要:在室温下,通过与甲醇中的三丁基锡烷反应,N-取代环状亚胺盐可以方便地还原成相应的叔胺,而且收率很高.在这些条件下,分子中存在的各种官能团(如酮基)不会受到影响.
    DOI:10.1055/s-1985-31434

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    专利信息


    专利号:US-10925977-B2
    优先权日:2006-10-05
    标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
    发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
    权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
    摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

    专利号:US-10814013-B2
    优先权日:2006-10-05
    标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

    专利号:US-2008107598-A1
    优先权日:2006-10-05
    标 题:Efficient Synthesis of Chelators for Nuclear Imaging and Radiotherapy: Compositions and Applications

    专利号:EP-2079486-A2
    优先权日:2006-10-05
    标题:Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

    专利号:US-2013039853-A1
    优先权日:2006-10-05
    标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

    专利号:CN-101678118-A
    优先权日:2006-10-05
    标 题:Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

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    主要参考文献


    1: Verma SK, Goyary D, Singh AK, Anandhan S, Raina SN, Pandey S, Kumar S, Khare N. Modulation of terpenoid indole alkaloid pathway via elicitation with phytosynthesized silver nanoparticles for the enhancement of ajmalicine, a pharmaceutically important alkaloid. Planta. 2023 Dec 27;259(2):30. doi: 10.1007/s00425-023-04311-z. 38(1):e23614. doi: 10.1002/jbt.23614. Epub 2023 Dec 8.
    962:176251. doi: 10.1016/j.ejphar.2023.176251. Epub 2023 Dec 5. 28(5):2370. doi: 10.3390/molecules28052370.
    5: Liu T, Gou Y, Zhang B, Gao R, Dong C, Qi M, Jiang L, Ding X, Li C, Lian J. Construction of ajmalicine and sanguinarine de novo biosynthetic pathways using stable integration sites in yeast. Biotechnol Bioeng. 2022 May;119(5):1314-1326. doi: 10.1002/bit.28040. Epub 2022 Jan 31.

    合成参考文献


    参考文献:10.1007/s00425-005-0167-y
    摘要:Mahroug S, Courdavault V, Thiersault M, St-Pierre B, Burlat V. Epidermis is a pivotal site of at least four secondary metabolic pathways in Catharanthus roseus aerial organs. Planta. 2006 May;223(6):1191–200. doi: 10.1007/s00425-005-0167-y.
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