CAS: 4733-50-0; 3,6-Dihydroxyphthalonitrile

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CAS号151-50-8 氰化钾 | CAS号106-51-4 苯醌 | CAS号74-90-8 氢氰酸 | CAS号83575-18-2 2,3-dicyan°Cycl... | CAS号83575-20-6 2,3-dihydro-5,6... | CAS号695-99-8 2-氯-1,4-苯醌 | CAS号64-17-5 乙醇 | CAS号4622-04-2 2,3-dicyano-p-b... | CAS号7732-18-5 水 | CAS号7664-93-9 硫酸 | CAS号91-15-6 邻苯二甲腈 | CAS号28231-51-8 (2,3-dicyano-4-... | CAS号10264-67-2 3,6-diethoxyben... | CAS号116453-85-1 3,6-diheptoxybe... | CAS号201140-18-3 3,6-di(propan-2... | CAS号116453-87-3 3,6-dipropoxybe... | CAS号14597-12-7 3,6-Dimethoxyph... | CAS号75941-30-9 3-羟基-6-(戊基氧基)-1... | CAS号75941-32-1 3-丁氧基-6-羟基-1,2-苯二甲腈 | CAS号75941-33-2 3-hexoxy-6-hydr...

在 Palladium Diacetate,Sodium Hydride体系中,用 N,N-二甲基乙酰胺 作为反应溶剂,化学反应 8.0H,以91%的收率获得产物3,6-二羟基邻苯二甲腈
参考文献:钯催化氢化钠对醚和酯的脱苄基作用和去甲酰化作用
标题:钯催化氢化钠对醚和酯的脱苄基作用和去甲酰化作用
摘要:在这里,我们简单地证明,添加pd(oac)2作为促进剂会将常用的碱式nah的反应性切换为亲核还原剂.反应性被设计成钯催化的芳基醚和酯的还原性脱苄基作用和脱甲酰化作用.该操作简单,温和的方案显示了广泛的底物范围和宽泛的官能团耐受性(> 50个实例),并且对脂族结构上的芳基醚具有高化学选择性.此外,在有效的合成工艺中证明了nah作为碱和还原剂的双重反应性.
DOI:10.1021/acscatal.8B00185

专利信息

专利号:WO-2005121077-A1
优先权日:2004-06-10
标题:Preparation and applications of polymer-supported halogenated benzoquinones as oxidative agents
发明人：COULADOUROS ELIAS; STRONGILOS ALEXANDROS
权利人:COULADOUROS ELIAS; STRONGILOS ALEXANDROS
摘要:This invention provides a general method for the synthesis of polymer-supported benzoquinones described by the following generic structure I: wherein: •, X, R1, R2 and R3 are described in the main text. The general concept of the method consists of the use of a halogenated starting material of the general structure II (Figure 1) which by an nucleophilic substitution reaction (NSR) or a palladium mediated coupling (PMC) is either directly loaded on a resin to afford IIIa (Path A) or transformed to intermediate IIIb (Path B) which is subsequently (with or without modification) loaded on a resin to afford once again IIIa. Deprotection and/or oxidation of IIIa, if needed, afford target solid-supported oxidants I The polymer-supported benzoquinones I are used for the oxidation of hydroquinones to quinones, for the oxidation of benzylic alcohols the aldehydes, for the removal of p-methoxybenzyl and related protective groups, for the dehydrogenation of tetrahydronaphthalene derivatives and for the dehydrogenation of steroid 4-en-3-ones. The polymer-supported reagent after its use is regenerated upon treatment with an oxidative agent.

专利号:US-8461298-B2
优先权日:2004-11-01
标 题:Compositions and methods for modification of biomolecules
发明人：BERTOZZI CAROLYN R; AGARD NICHOLAS J; PRESCHER JENNIFER A; BASKIN JEREMY MICHAEL
权利人:BERTOZZI CAROLYN R; AGARD NICHOLAS J; PRESCHER JENNIFER A; BASKIN JEREMY MICHAEL; UNIV CALIFORNIA
摘要:The present invention provides modified cycloalkyne compounds; and method of use of such compounds in modifying biomolecules. The present invention features a cycloaddition reaction that can be carried out under physiological conditions. In general, the invention involves reacting a modified cycloalkyne with an azide moiety on a target biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provide for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).

专利号:US-4226800-A
优先权日:1979-06-14
标 题 :Synthesis of acetylene-terminated compounds
发明人：PICKLESIMER LEWELLYN G
权利人:US AIR FORCE
摘要:Phenolic materials containing propargyl groups are prepared by reacting a polyhydric, phenolic material with propargyl bromide, the reaction being conducted in an aqueous sodium hydroxide solution. The products can be thermally polymerized to polymers which are useful as adhesives and as matrix resins in the fabrication of composites.

专利号:US-12071422-B2
优先权日:2022-02-07
标 题 :Process for synthesis of quinazoline compounds
发明人：LEBL RENE; LIM NGIAP KIE; MEIER ROLAND CHRISTOPH; ORCEL UGO JONATHAN; SEDELMEIER JOERG; SHEN JEFF; SIROIS LAUREN ELIZABETH; TIMMERMAN JACOB C; TRACHSEL ETIENNE; WHITE NICHOLAS ANDREW; XU JIE; ZHANG HAIMING; BACHMANN STEPHAN; BASS THOMAS MICHAEL; BIGLER RAPHAEL; BURKHARD JOHANNES ADRIAN; CLAGG KYLE BRADLEY PASCUAL; GOSSELIN FRANCIS; HAN CHONG; KALDRE DAINIS; KELLY SEAN M; HEROLD SEBASTIAN; LEITNER CHRISTIAN
权利人:GENENTECH INC; HOFFMANN LA ROCHE
摘要:Provided herein are methods to synthesize compounds useful in the treatment of cancer where such compounds comprise a quinazolinyl core moiety and at least one stereoisomeric or atropisomeric moiety.

专利号:US-9260371-B2
优先权日:2004-11-01
标题:Compositions and methods for modification of biomolecules
发明人：BERTOZZI CAROLYN RUTH; AGARD NICHOLAS J; PRESCHER JENNIFER A; BASKIN JEREMY MICHAEL; SLETTEN ELLEN MAY
权利人:UNIV CALIFORNIA
摘要:The present invention provides modified cycloalkyne compounds; and method of use of such compounds in modifying biomolecules. The present invention features a cycloaddition reaction that can be carried out under physiological conditions. In general, the invention involves reacting a modified cycloalkyne with an azide moiety on a target biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provide for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).

专利号:CN-105646641-A
优先权日:2016-02-26
标题:Formation method of 1,2 double bond in the synthesis of finasteride and dutasteride