CAS: 4692-98-2; 5-Bromoisatoic Anhydride

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📜靛红置于n-溴代丁二酰亚胺(Nbs)体系中,用 乙腈 作为反应溶剂,化学反应 528.0H,以77%的收率获得产物5-溴靛红酸酐
参考文献:某些氨基和硫烷基-3 H-喹唑啉-4-酮衍生物的合成及生物学评价
标题:某些氨基和硫烷基-3 H-喹唑啉-4-酮衍生物的合成及生物学评价
摘要:摘要在buchwald-hartwig型反应条件下,在pd(oac)2 / Xantphos体系存在下,通过6-溴喹唑啉酮与芳基或烷基胺和硫醇的反应,制备了一系列6-取代喹唑啉酮衍生物.通过5-溴氨基苯甲酸酐,原甲酸三乙酯和适当的胺的三组分反应获得6-溴喹唑啉酮.对合成化合物对ht29和hct116细胞系以及对淋巴细胞的潜在细胞毒性的生物学筛选显示,喹唑啉酮的某些衍生物具有显着的抗癌活性.报告了详细的合成,光谱数据和生物学分析. 图形概要
DOI:10.1007/s00706-015-1508-6

专利信息

专利号:US-6525061-B1
优先权日:1999-11-16
标题 :Methods for the solid phase synthesis of 2-amino-4(H)-quinazolinone derivatives
发明人：GOPALSAMY ARIAMALA; YANG HUI Y
权利人:WYETH CORP
摘要:The present invention relates to solid phase synthesis of substituted 2-amino-4(H)-quinazolinone compounds of formula (I):having pharmacological activity, to processes for their preparation, to a combinatorial library and solid phase methods for preparing libraries of the compounds, to utilizing libraries of the compounds for drug discovery, and to pharmaceutical compositions thereof.

专利号:US-2012189547-A1
优先权日:2009-10-08
标 题 :[18f] labelled analogues of flumazenil as in vivo imaging agents
发明人：WOODCRAFT JOHN; JONES CLARE L; GAETA ALESSANDRA; TRIGG WILLIAM JOHN; JONES PAUL ALEXANDER; PLANT STUART
权利人:WOODCRAFT JOHN; JONES CLARE L; GAETA ALESSANDRA; TRIGG WILLIAM JOHN; JONES PAUL ALEXANDER; PLANT STUART
摘要:The present invention provides radiofluorinated compounds useful for in vivo imaging GABA A receptors. Also provided by the present invention is a method of synthesis for the radiofluorinated compounds of the invention, in particular an automated method of synthesis. A further aspect of the invention is a cassette suitable for carrying out the automated method of synthesis of the invention.

专利号:US-9364482-B2
优先权日:2013-06-24
标 题 :Substituted benzofuran compounds and methods of use thereof for the treatment of viral diseases
发明人：DAI XING; LIU HONG; PALANI ANANDAN; HE SHUWEN; NARGUND RAVI; XIAO DONG; ZORN NICOLAS; DANG QUN; MCCOMAS CASEY C; PENG XUANJIA; LI PENG; SOLL RICHARD
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula I that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system. (I)

专利号:US-8946410-B2
优先权日:2009-10-08
标 题 :Automated radiosynthesis
发明人：WOODCRAFT JOHN; JONES L CLARE; GAETA ALESSANDRA; TRIGG JOHN WILLIAM; JONES ALEXANDER PAUL; PLANT STUART; JACKSON ALEXANDER
权利人:WOODCRAFT JOHN; JONES L CLARE; GAETA ALESSANDRA; TRIGG JOHN WILLIAM; JONES ALEXANDER PAUL; PLANT STUART; JACKSON ALEXANDER; GE HEALTHCARE LTD
摘要:The present invention provides a method to obtain radiofluorinated compounds useful for in vivo imaging GABA A receptors. The method of the invention is high-yielding and may conveniently be carried out on an automated synthesizer such as Fastlabâ„¢. A further aspect of the invention is a cassette suitable for carrying out the automated method of synthesis of the invention. Novel precursor compounds useful in the method of the invention are also provided, as are a number of novel compounds obtained by the method of the invention.

专利号:CN-118910629-A
优先权日:2024-07-30
标题:A method for electrochemical synthesis of quinazolinone derivatives

专利号:US-2024343719-A1
优先权日:2017-03-17
标题 :Kappa opioid receptor antagonists and products and methods related thereto
发明人：ROBERTS EDWARD; GUERRERO MIGUEL A; URBANO MARIANGELA; ROSEN HUGH; JONES ROBERT M; LAXAMANA CANDACE MAE; ZHAO XIANRUI; TURTLE ERIC DOUGLAS
权利人:SCRIPPS RESEARCH INST; BLACKTHORN THERAPEUTICS INC
摘要:Compounds are provided that antagonize the kappa-opioid receptor (KOR) and products containing such compounds, as well as to methods of their use and synthesis. Such compounds have the structure of Formula (I), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope or salt thereof: n n n n n n n n n n wherein X, Y, R 1 , R 2 , R 4 , R 5 R 6 , R 7 , R 8 and R 11 are as defined herein.