CAS: 45127-11-5; 2,2'-Disulfanediyldiethanesulfonic Acid

上下游产品

CAS号19767-45-4 美司那 | CAS号4263-52-9 2-溴乙基磺酸钠 | CAS号3375-50-6 2-巯基乙磺酸

📜3,4-Dithia-1,6-Hexan-Disulfonyl-Chlorid置于水体系中,用 乙腈 作为反应溶剂,化学反应 120.0H,以96%的收率获得产物辅酶 M
参考文献:Medicinal Disulfide Salts
标题:Medicinal Disulfide Salts
摘要:这项发明涉及新型药用二硫化物盐.这些化合物包括一个末端磺酸盐或膦酸盐基团,并具有许多用途,例如在与许多抗肿瘤药物一起使用时作为毒性减少剂.

专利信息

专利号:EP-1499587-A4
优先权日:2002-04-30
标 题:PROCESS FOR SYNTHESIS OF PHARMACEUTICALLY ACTIVE DISULFIDE SALTS

专利号:US-2009232906-A1
优先权日:2008-03-14
标 题 :Treatment methods and compositions for lung cancer, adenocarcinoma, and other medical conditions
发明人：HAUSHEER FREDERICK H
权利人:BIONUMERIK PHARMACEUTICALS INC
摘要:The present invention discloses and claims: (i) compositions, methods, and kits which lead to an increase in patient survival time in cancer patients receiving chemotherapy; (ii) compositions and methods which cause cytotoxic or apoptotic potentiation of the anti-cancer activity of chemotherapeutic agents; (iii) compositions and methods for maintaining or stimulating hematological function in patients in need thereof, including those patients suffering from cancer; (iv) compositions and methods for maintaining or stimulating erythropoietin function or synthesis in patients in need thereof, including those patients suffering from cancer; (v) compositions and methods for mitigating or preventing anemia in patients in need thereof, including those patients suffering from cancer; (vi) compositions and methods for maintaining or stimulating pluripotent, multipotent, and unipotent normal stem cell function or synthesis in patients in need thereof, including those patients suffering from cancer; (vii) compositions and methods which promote the arrest or retardation of tumor progression in those cancer patients receiving chemotherapy; (viii) compositions and methods for increasing patient survival and/or delaying tumor progression while maintaining or improving the quality of life in a cancer patient receiving chemotherapy; (ix) novel methods of the administration of taxane and/or platinum medicaments and a Formula (I) compound of the present invention to a cancer patient; and (x) kits to achieve one or more of the aforementioned physiological effects in a patient in need thereof, including those patients suffering from cancer.