专利号:US-9051302-B2 优先权日:2008-01-15 标 题 :Synthesis of resorcylic acid lactones useful as therapeutic agents 发明人:WINSSINGER NICOLAS; BARLUENGA SOFIA; KARPLUS MARTIN 权利人:WINSSINGER NICOLAS; BARLUENGA SOFIA; KARPLUS MARTIN; UNIV STRASBOURG 摘要:Disclosed are macrocyclic compounds of formulae I, I′, II, II′, III, III′, IV, and V, which are analogs of the pochonin resorcylic acid lactones, pharmaceutical compositions comprising the compounds, and methods and uses comprising the compounds for the treatment of diseases mediated by kinases and Heat Shock Protein 90 HSP90.
专利号:US-10239856-B2 优先权日:2008-01-15 标题:Synthesis of resorcylic acid lactones useful as therapeutic agents
专利号:CN-101990399-B 优先权日:2008-01-15 标 题:Synthesis of dihydroxybenzoic acid lactones as therapeutic agents
专利号:US-2011217335-A1 优先权日:2008-01-15 标 题 :Synthesis of resorcylic acid lactones useful as therapeutic agents
专利号:US-2016075677-A1 优先权日:2008-01-15 标 题:Synthesis of resorcylic acid lactones useful as therapeutic agents
专利号:EP-2242359-A1 优先权日:2008-01-15 标 题:Synthesis of resorcylic acid lactones useful as therapeutic agents
参考标题: Synthesis Of Resorcylic Acid Lactones Useful As Therapeutic Agents Synthèse De Lactones D'Acide Résorcylique Utiles En Tant Qu'Agents Thérapeutiques 摘要:Disclosed Are Macrocyclic Compounds Of Formulae I, I', Ii, Ii', Iii, Iii', Iv, And V, Which Are Analogs Of The Pochonin Resorcylic Acid Lactones, Pharmaceutical Compositions Comprising The Compounds, And Methods And Uses Comprising The Compounds For The Treatment Of Diseases Mediated By Kinases And Heat Shock Protein 90 Hsp90.
合成参考文献
参考文献:10.1007/s11101-024-09956-6 摘要:Fazliev S, Tursunov K, Sharipov A, Xaydarov V, Normakhamatov N, Rizaev K, Wang T, Aisa HA. Escin’s phytochemistry and pharmacy: biosynthesis, chemistry, synergism and novel activities. Phytochem Rev. 2024 Jul 16;24(2):1345–63. doi: 10.1007/s11101-024-09956-6.