CAS: 38821-53-3; Cephradine

上下游产品

R)-3-methyl-8-oxo-7t-(trimethylsilanyl-amino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]°Ct-2-ene-2-carboxylic acid trimethylsilanyl ester(6R)-3-methyl-8-oxo-7t-(trimethylsilanyl-amino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]°Ct-2-ene-2-carboxylic acid trimethylsilanyl ester (R)-2-(tert-butoxycarbonylamino)-2-(cyclohexa-1,4-dienyl)acetic acid N-tert-butyloxycarbonylcefradine 3-deacetyloxy-7-amin°Cephalosporanic acidN-tert-butyloxycarbonylcefradine 3-hydroxy-4-methyl-2(5H)-thiophenone cefalexin (6R,7R)-3-methyl-7-[(R)-2-amino-2-phenylacetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]°Ct-3-ene-2-carboxylic acid

(R)-(-)-2-(2,5-二氢苯基)甘氨酸置于ammonium Hydroxide,硫酸体系中,用 水 用作溶剂,化学反应 1.5H,反应生成头孢拉定
参考文献: Salt Of Dihydrophenylglycine Methyl Ester[fr] Sel D'Ester Méthylique De Dihydrophénylglycine
标题: Salt Of Dihydrophenylglycine Methyl Ester[fr] Sel D'Ester Méthylique De Dihydrophénylglycine
摘要:本发明涉及甲基(R)-2-氨基-2-(环己-1,4-二烯-1-基)乙酸盐酸半酯,也被称为d-双氢苯基甘氨酸甲酯盐酸半酯,以及制备该盐酸半酯的方法和在抗生素的酶合成中使用该盐酸半酯的用途.

专利信息

专利号:US-2005186197-A1
优先权日:2002-08-29
标 题:Peptide inhibitors of beta lactamases
发明人：PALZKILL TIMOTHY; HUANG WANZHI
摘要:Peptide inhibitors of β-lactamases have been identified by the synthesis of peptide arrays using synthesis SPOT technology. These peptide inhibitors of β-lactamase have activity against a broad spectrum of β-lactamases and are useful in a variety of applications.

专利号:US-2018222848-A1
优先权日:2015-08-04
标 题:Salt of Dihydrophenylglycine Methyl Ester
发明人：VAN DER DOES THOMAS; MOODY HAROLD MONRO; LI WEIDONG
权利人:DSM SINOCHEM PHARM NL BV
摘要:The present invention relates to the hemi sulfuric acid salt of methyl (R)-2-amino-2-(cyclohexa-1,4-dien-1-yl)acetate, also trivially referred to as the hemi sulfuric acid salt of D-dihydrophenylglycine methyl ester, to a method for the preparation of said salt and to the use of said salt in the enzymatic synthesis of antibiotics.

专利号:US-8658711-B2
优先权日:2010-09-29
标题 :Process for the synthesis of methacrylate-derivatized type-1 collagen and derivatives thereof
发明人：SHREIBER DAVID; GAUDET IAN
权利人:SHREIBER DAVID; GAUDET IAN; UNIV RUTGERS
摘要:Methods for synthesizing a methacrylate-derivatized type-I collagen in which methacrylic acid is reacted with a carboxylic acid activating reagent in the presence of a carbodiimide to form a methacrylic acid with an activated carboxylic acid group, which is then reacted with free amino groups on type-I collagen to form a collagen methacrylamide. Methacrylate-derivatized collagen, cross-linked collagens formed therefrom and products containing the cross-linked collagen are also disclosed.

专利号:US-8017776-B2
优先权日:2003-07-15
标题 :Methods for synthesis of acyloxyalkyl compounds
发明人：BHAT LAXMINARAYAN; GALLOP MARK A
权利人:XENOPORT INC
摘要:Disclosed herein are methods for synthesizing 1-(acyloxy)-alkyl prodrug derivatives of drugs through oxidation of 1-acyl-alkyl derivatives of drugs under anhydrous reaction conditions. The methods typically proceed stereospecifically, in high yield, do not require the use of activated intermediates and/or toxic compounds and are readily amenable to scale-up.

专利号:WO-9856944-A1
优先权日:1997-06-10
标 题 :APPLICATION OF REDUCING SULPHUR COMPOUNDS DURING ENZYMATIC PREPARATION OF β-LACTAM COMPOUNDS
发明人：WILMS JOHANNES; DE VROOM ERIK
权利人:GIST BROCADES BV; WILMS JOHANNES; VROOM ERIK DE
摘要:Disclosed is a method to improve the quality of enzymatic hydrolysis or synthesis of the substituted β-lactam compounds with respect to enzyme productivity, product quality and process streamlining (prevention of the formation deposits) by the addition of reducing sulphur compounds, such as sodium sulphite or sodium metabisulphite.

专利号:US-8497088-B2
优先权日:2007-03-09
标题:Process for the preparation of beta-lactam compounds
发明人：VAN DER DOES THOMAS; MOODY HAROLD MONRO; VAN DOOREN THEODORUS JOHANNES GODFRIED MARIA
权利人:VAN DER DOES THOMAS; MOODY HAROLD MONRO; VAN DOOREN THEODORUS JOHANNES GODFRIED MARIA; DSM SINOCHEM PHARM NL BV
摘要:The present invention describes a process for the synthesis of a semi-synthetic β-lactam compound from a nucleus and a side chain selected from the group consisting of D-phenylglycine and D-dihydro-phenylglycine in the form of a side chain ester and an enzyme catalyzing the coupling of the side chain ester to the nucleus characterized in that the side chain ester is not isolated as a solid intermediate.