CAS: 38444-90-5; 3,4,4'-Trichloro-1,1'-Biphenyl

该化合物是多氯联苯(PCB)家族的成员,该家族由以其环境持久性和潜在毒性而闻名的合成有机化学品组成.PCB 37的特点是其双联体结构,在双苯环上的特定位置替换氯原子.这种化合物通常具有疏水特性,使其在水中无法溶解,但在有机溶剂中可溶解.多氯联苯,包括PCB 37,因其稳定性和降解耐力而闻名,有助于其在环境和生物生物体内的积累.它们可以在食物链中生物累积,导致潜在的健康风险,如内分泌干扰和致癌影响.由于这些关切,许多国家禁止或限制多氯联苯.多氯联苯37与其他多氯联苯一样,受环境条例的约束,并监测其在环境中的存在,以减轻对人类健康和生态系统的风险.

英文名称3,4,4'-Trichloro-1,1'-Biphenyl
中文名称3,4,4'-三氯-1,1'-联苯
IUPAC名称1,2-dichloro-4-(4-chlorophenyl)benzene
其它别名3,4,4'-三氯联苯; 3,4,4'-Trichlorobiphenyl
CAS编号38444-90-5
MFCD编号:MFCD00152904
FDA UNII编号:XU26WI08F0
分子式:C12H7Cl3分子量:257.54
产品CID: 1396612
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: YZANRISAORXTHU-UHFFFAOYSA-N
1S/C12H7Cl3/c13-10-4-1-8(2-5-10)9-3-6-11(14)12(15)7-9/h1-7H
计算化学: 氢键受体数*氢键供体数*可旋转键数1.0

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H319-H335
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
安全声明The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. Most of the toxic effects of PCBs are believed to be results of Ah receptor binding. Other PBCs are believed to interfere with calcium channels and/or change brain dopamine levels. PCBs can also cause endocrine disurption by altering the production of thyroid hormones and binding to estrogen receptors, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. They will bioaccumulate by binding to receptor proteins such as uteroglobin. (A3, A4, A30, A66)

上下游产品

biphenyl

合成工艺路线路线简述

📜3,4-二氯碘苯,4-氯苯硼酸置于c20H29Cl2N5O2Pd,Potassium Carbonate体系中,用乙醇用作溶剂,化学反应 2.5H,反应生成3,4,4'-三氯联苯
参考文献:Regularities Of Pd/c-Catalyzed Reduction Of Trichlorobiphenyls With 2-Propanol In Basic Medium
标题:Regularities Of Pd/c-Catalyzed Reduction Of Trichlorobiphenyls With 2-Propanol In Basic Medium
摘要:Reduction Of A Series Of Trichlorobiphenyls With 2-Propanol In Basic Medium Catalyzed By Pd/c Has Been Studied. Regioselectivity Of The Reduction Has Been Determined. In The Studied Cases,The Chlorine Atom In Para Or Meta Positions Of The More Substituted Ring Has Been More Reactive. Using Isotope Labeling,It Has Been Demonstrated That The Reaction occurs Via The Stage Of 2-Propanol Dehydration On Palladium Catalyst,Followed By Catalytic Hydrogenation Of The Polychlorinated Biphenyls.
Doi:10.1134/s1070363217080023