CAS: 38260-01-4; N1,N1'-(Ethane-1,2-Diyl)Bis(Ethane-1,2-Diamine) Dihydrochloride

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CAS号4961-40-4 三乙四胺四盐酸盐 | CAS号81904-67-8 1,3-bis-(2-benz...

📜Tert-Butyl (N-2-Aminoethyl)N-([2-((2-Aminoethyl)T-Butyloxy)Carbonylamino]Ethyl)Carbamate 在 盐酸体系中,用 水作为反应溶剂,以70%的收率获得n,N'-Bis(2-Aminoethyl)Ethane-1,2-Diamine DihydroChloride
参考文献:[En] An Improved Process For Preparation Of Trientine DihydroChloride[Fr] Pr°Cédé Amélioré De Préparation De Dichlorhydrate De Trientine
标题:[En] An Improved Process For Preparation Of Trientine DihydroChloride[Fr] Pr°Cédé Amélioré De Préparation De Dichlorhydrate De Trientine
摘要:本发明提供了一种三乙烯四胺二盐酸盐(1)的制备方法,包括在水系中将保护的三乙烯四胺与盐酸反应,得到二盐酸盐,其中显著控制了无机杂质和不需要的盐的形成.

专利信息

专利号:WO-2018193482-A1
优先权日:2017-04-22
标 题 :Improved method for the synthesis of 1,2-ethanediamine, n, n'-bis(2-aminoethyl)-dihydrochloride(trientine dihydrochloride)
发明人：PULLAGURLA MANIK REDDY; PITTA BHASKAR REDDY; NAMANA SURESH BABU; RANGISETTY JAGADEESH BABU
权利人:BIOPHORE INDIA PHARMACEUTICALS PVT LTD
摘要:The present invention relates to an improved method for the synthesis of substantially pure 1,2-ethanediamine, N, N'-bis(2-aminoethyl)-dihydrochloride (I). Formula (I). Î?,Î?'-bis (2-aminoethyl)-l,2-ethanediamine dihydrochloride (Trientine dihydrochloride)

专利号:US-9556123-B2
优先权日:2004-07-19
标题:Synthesis of triethylenetetramines
发明人：JONAS MARCO; VAULONT IRENE; SOI ANTONIO; SCHMIDT GUNTHER
权利人:PHILERA NEW ZEALAND LTD
摘要:Methods and intermediates for synthesizing triethylenetetramine and salts thereof, as well as novel triethylenetetramine salts and their crystal structure, and triethylenetetramine salts of high purity.

专利号:US-2005085555-A1
优先权日:1997-08-21
标 题:Composition, synthesis and therapeutic applications of polyamines
发明人：MURPHY MICHAEL A; MALACHOWSKI MITCHELL R
摘要:This invention relates to a process of synthesis and composition of open chain (ring), closed ring, linear branched and or substituted polyamines, polyamine derived tyrosine phosphatase inhibitors and PPAR partial agonists/partial antagonists via a series of substitution reactions and optimizing the bioavailability and biological activities of the compounds. Polyamines prevent the toxicty of neutoxins and diabetogenic toxins including paraquat, methyphenyl pyridine radical, rotenone, diazoxide, streptozotocin and alloxan. These polyamines can be to treat neurological, cardiovascular, endocrine acquired and inherited mitochondrial DNA damage diseases and other disorders in mammalian subjects, and more specifically to the therapy of Parkinson's disease, Alzheimer's disease, Lou Gehrig's disease, Binswanger's disease, Olivopontine Cerebellar Degeneration, Lewy Body disease, Diabetes, Stroke, Atherosclerosis, Myocardial Ischemia, Cardiomyopathy, Nephropathy, Ischemia, Glaucoma, Presbycussis, Cancer, Osteoporosis, Rheumatoid Arthritis, Inflammatory Bowel Disease, Multiple Sclerosis and as Antidotes to Toxin Exposure.

专利号:US-2014057877-A1
优先权日:2002-12-18
标题:Therapeutic polyamine compositions and their synthesis
发明人：MURPHY MICHAEL A; MALACHOWSKI MITCHELL R
权利人:MURPHY MICHAEL A; MALACHOWSKI MITCHELL R
摘要:This invention relates to a process of synthesis and composition of open chain (ring), closed ring, linear branched and or substituted polyamines, polyamine derived tyrosine phosphatase inhibitors and PPAR partial agonists/partial antagonists via a series of substitution reactions and optimizing the bioavailability and biological activities of the compounds. Polyamines prevent the toxicity of neurotoxins and diabetogenic toxins including paraquat, methyphenyl pyridine radical, rotenone, diazoxide, streptozotocin and alloxan. These polyamines can be utilized to treat neurological, cardiovascular, endocrine acquired and inherited mitochondrial DNA damage diseases and other disorders in mammalian subjects, and more specifically to the therapy of Parkinson's disease, Alzheimer's disease, Lou Gehrig's disease, Binswanger's disease, Olivopontine Cerebellar Degeneration, Lewy Body disease, Diabetes, Stroke, Atherosclerosis, Myocardial Ischemia, Cardiomyopathy, Nephropathy, Ischemia, Glaucoma, Presbycussis, Cancer, Osteoporosis, Rheumatoid Arthritis, Inflammatory Bowel Disease, Multiple Sclerosis and as Antidotes to Toxin Exposure.

专利号:US-2020148647-A1
优先权日:2004-07-19
标题:Synthesis of Triethylenetetramines

专利号:US-2013345311-A1
优先权日:2004-07-19
标 题 :Synthesis Of Triethylenetetramines