CAS: 3722-51-8; 3-Hydroxyxanthen-9-One

上下游产品

CAS号3722-52-9 3-甲氧基-9H-呫吨-9-酮 | CAS号13087-18-8 2,2’-4-三羟基二苯甲酮 | CAS号33077-87-1 2,2',4-三甲氧基苯甲酮 | CAS号131-53-3 二羟苯宗 | CAS号69-72-7 水杨酸 | CAS号151-10-0 间苯二甲醚 | CAS号21615-34-9 邻甲氧基苯甲酰氯 | CAS号108-46-3 间苯二酚 | CAS号118-55-8 水杨酸苯酯 | CAS号150-19-6 3-甲氧基苯酚 | CAS号92-83-1 氧杂蒽 | CAS号2238-07-5 二缩水甘油醚 | CAS号3722-52-9 3-甲氧基-9H-呫吨-9-酮 | CAS号731-66-8 3-hydroxy-4-pro... | CAS号88498-80-0 4-bromo-3-hydro... | CAS号88498-81-1 4-bromo-3-prop-... | CAS号88498-84-4 4-bromo-3-hydro... | CAS号88498-85-5 [4-bromo-2-(2,3... | CAS号88498-86-6 11-bromo-2-meth... | CAS号88498-87-7 11-bromofuro[3,...

2,2'-4-三羟基二苯甲酮置于sodium Acetate体系中,用 水 作为反应溶剂,化学反应 0.13H,以99%的收率获得产物西伯尔链接剂
参考文献:Synthesis And Evaluation Of Novel Aza-Caged Garcinia Xanthones
标题:Synthesis And Evaluation Of Novel Aza-Caged Garcinia Xanthones
摘要:受简化笼型呫吨酮治疗潜力的启发,我们开发了一种化学策略,通过区域选择性claisen/diels-Alder串联反应合成新颖的氮笼型藤黄模拟物.区域选择性的起源已通过dft方法解释.我们进一步评估了这些化合物的细胞增殖和ikkβ抑制活性,并通过分子对接研究了它们与ikkβ的结合模式.结果表明,氮笼型骨架提供了合适的修饰位点,疏水基团的引入提高了细胞毒性和ikkβ抑制活性.氮笼型化合物6C对hepg2,A549细胞和ikkβ的ic50值分别为2.68,2.10,8.02 μm.6C的机理研究表明,氮笼型化合物诱导a549细胞凋亡和细胞周期s期阻滞.
DOI:10.1039/c2Ob07088J

专利信息

专利号:WO-2024181781-A1
优先权日:2023-02-27
标 题:Substrate for synthesis of biological polymers having anti-aggregation function and biological polymer synthesis method using same
发明人：JANG MYOUNG HOON; CHOI JAE SUN
权利人:SP2 TX INC
摘要:The present invention relates to a substrate for the synthesis of biological polymers having an anti-aggregation function, and a biological polymer synthesis method using the substrate. The substrate according to an aspect may have anti-aggregation functionality to enable high-yield and high-purity processes in the synthesis of biological polymers.

专利号:US-11571456-B2
优先权日:2017-05-23
标题 :Process for the linear synthesis of gram-positive class II bacteriocins and compositions and uses thereof
发明人：BÉDARD FRANÇOIS; BIRON ÉRIC; HAMMAMI RIADH; FLISS ISMAIL
权利人:UNIV LAVAL
摘要:A process for the linear synthesis of a gram-positive class II bacteriocin or a variant thereof is disclosed herein. The process comprises the stepwise addition of selected amino acids to a solid support; pseudoproline positioning and reopening; and cleavage of the gram-positive class II bacteriocin or the variant thereof from the solid support to provide a linear gram-positive class II bacteriocin or variant thereof; and in situ disulfide bond formation. Various applications and uses of the synthetic bacteriocins are also disclosed. The synthetic process can also be used to synthesize variants of bacteriocins by the selective substitution of one or more amino acids and/or additions and/or deletions of selected amino acids.

专利号:US-2023337702-A1
优先权日:2017-05-23
标 题 :Process for the linear synthesis of gram-positive class ii bacteriocins and compositions and uses thereof
发明人：BÉDARD FRANÇOIS; BIRON ÉRIC; HAMMAMI RIADH; FLISS ISMAIL; RENAUD ARIANE; DALLAIRE LAURENT
权利人:UNIV LAVAL
摘要:A process for the linear synthesis of a gram-positive class II bacteriocin or a variant thereof is disclosed herein. The process comprises the stepwise addition of selected amino acids to a solid support; pseudoproline positioning and reopening; and cleavage of the gram-positive class II bacteriocin or the variant thereof from the solid support to provide a linear gram-positive class II bacteriocin or variant thereof; and in situ disulfide bond formation. Various applications and uses of the synthetic bacteriocins are also disclosed. The synthetic process can also be used to synthesize variants of bacteriocins by the selective substitution of one or more amino acids and/or additions and/or deletions of selected amino acids.

专利号:US-6132953-A
优先权日:1996-07-02
标 题 :Combinatorial synthesis on soluble polyvalent supports having a discrete architecture
发明人：CHAPMAN KEVIN T; HUTCHINS STEVEN M; KIM RONALD M; MANNA MAHUA
权利人:MERCK & CO INC
摘要:The present invention is directed to the use of a soluble polyvalent support for the preparation of combinatorial libraries of compounds. The resultant combinatorial libraries are useful in screening for biologically active moieties in the drug discovery process or in developing compounds with desired physical and chemical properties.

专利号:EP-1869066-A1
优先权日:2005-04-08
标题:Peptide synthesis of alpha-helixes on peg resin

专利号:JP-2008534639-A
优先权日:2005-04-08
标 题:Peptide synthesis of alpha-helix on PEG resin