CAS: 2995-45-1; 1-Nitro-3-(Trifluoromethoxy)Benzene

上下游产品

间硝基苯酚 Meta-Nitrophenol 554-84-7
3-三氟甲氧基苯胺 M-Trifluoromethoxyaniline 1535-73-5

3-三氟甲氧基苯胺置于二过氧壬二酸体系中,用 乙腈 用作溶剂,化学反应 0.5H,以90%的收率获得间硝基三氟甲氧基苯
参考文献:Steric-Hindrance-Induced Regio-And Chemoselective Oxidation Of Aromatic Amines
标题:Steric-Hindrance-Induced Regio-And Chemoselective Oxidation Of Aromatic Amines
摘要:Unusual Regio-And Chemoselective Oxidation Of Aromatic Amines Hindered With Ortho Substituents (Except-Nh2,-Nhch3,And-Oh) To The Corresponding Nitro Compounds Is Described By Use Of Nonanebis(Peroxoic Acid). The Mechanistic Investigation For Selective Oxidation Of Amines Ortho-Substituted With-Nh2 Or-Oh Showed The Involvement Of H-Bonding Between The Ortho Hydrogen Of The Adjacent-Xh Group (Where X = Nh,Nr,Or O) And An Oxygen Atom From The Diperoxy Acid. Various Mono-And Diamines Are Oxidized Into Corresponding Mononitro Derivatives In High Yield And Purity Without Employing Any Protection Strategies. The Protocol Was Also Found To Successful On The Gram Scale.
Doi:10.1021/acs.Joc.5B00582

专利信息

专利号:US-4157344-A
优先权日:1978-01-16
标题 :Preparation of aryl trifluoromethyl ethers
发明人：FEIRING ANDREW E
权利人:DU PONT
摘要:A one-step process for the synthesis of aryl trifluoromethyl ethers by reacting phenol or certain substituted phenols with a perhalomethane and hydrogen fluoride is provided. The compounds produced by the process of this invention are useful intermediates in the production of dyestuffs and pharmaceuticals.