CAS: 2566-34-9; Meaib

该化合物是一种有机化合物,其特点是氨基氨基酸组和一个碳酸功能组的存在,它是异丁酸的衍生物,与甲型碳相连,甲基氨基酸组的衍生物,该化合物一般是白色晶状固体,由于其极分功能组而在水中可溶解,其分子结构允许其参与各种生物化学过程,使其在医药和生物化学等领域具有兴趣.氨基组的存在可影响其再活动及与其他分子的相互作用,并可能影响其生物活动.此外,(甲基乙基氨基)异丁基酸可能具有缓冲能力等特性,并可作为其他化合物合成的前体.应当与任何化学物质一道,对安全和处理预防措施加以观察,以减少接触或摄取的风险.

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相似化合物

15030-72-5 146000-39-7 30992-29-1

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上下游产品

CAS号593-51-1 一甲胺盐酸盐 | CAS号151-50-8 氰化钾 | CAS号67-64-1 丙酮 | CAS号2052-01-9 2-溴代异丁酸 | CAS号74-89-5 氨基甲烷 | CAS号146000-39-7 2-((叔丁氧基羰基)(甲基)...

合成工艺路线路线简述

  • 合成目标产物 N-Me-Aib-Oh Hcl 主要起始原料 2-Bromo-2-Methylpropionic Acid And Methylamine
  • (文献来源)合成步骤主要原料 2-Bromo-2-Methylpropionic Acid 和 Methylamine
📜2-溴-2-甲基丙酸,甲胺 反应生成2-(甲氨基)异丁酸水合物
参考文献:Bergel,Hoppe-Seyler'S Zeitschrift Fur Physiologische Chemie,1934,Vol. 223,P. 70
标题:Bergel,Hoppe-Seyler'S Zeitschrift Fur Physiologische Chemie,1934,Vol. 223,P. 70

海关参考信息

专利信息


专利号:US-10526379-B2
优先权日:2015-06-05
标题:Methods and products for fusion protein synthesis
发明人:HOWARTH MARK
权利人:UNIV OXFORD INNOVATION LTD
摘要:A method of producing a fusion protein is provided. The method includes: a) contacting a first protein with a second protein under conditions that enable the formation of an isopeptide bond between said proteins to form a linked protein; and b) contacting the linked protein from (a) with a third protein under conditions that enable the formation of an isopeptide bond between said third protein and said linked protein to form a fusion protein. Peptide linkers and the use of orthogonal pairs of said linkers in the synthesis of fusion proteins are also provided. Recombinant proteins comprising said linkers, nucleic acid molecules encoding said proteins and linkers, vectors comprising said nucleic acid molecules and host cells comprising said vectors and nucleic acid molecules are also contemplated.

专利号:WO-2008098280-A1
优先权日:2007-02-16
标题:Methods for the synthesis of dicarba bridges in growth hormone peptides
发明人:ROBINSON ANDREA JANE; VAN LIEROP BIANCA; WHELAN AMANDA
权利人:POLYCHIP PHARMACEUTICALS PTY; UNIV MONASH; ROBINSON ANDREA JANE; VAN LIEROP BIANCA; WHELAN AMANDA
摘要:The invention relates to peptides comprising the carboxy terminal sequence of a growth hormone or an analogue of such a peptide in which the disulfide bridge is replaced by a dicarba bridge. Compositions containing such dicarba bridged peptides and method of treating obesity in an animal such as a human comprising administration of such dicarba bridged peptides are also disclosed.

专利号:US-2023313156-A1
优先权日:2020-08-06
标题 :Chemical synthesis of large and mirror-image proteins and uses thereof
发明人:ZHU TING; Fan Chuyao; DENG QIANG; XU YUAN
权利人:UNIV TSINGHUA
摘要:Provided herein is a general method for producing large (more than 400 aa long) D-amino acids proteins, also referred to as mirror image protein (with respect to their naturally occurring L-amino acids counterparts), including RNA/DNA manipulating enzymes, and uses thereof in a wide range of research, practical data storage and medicinal applications.

专利号:US-2023364251-A1
优先权日:2020-08-06
标 题:Methods for the synthesis of protein-drug conjugates
发明人:BORCHARDT ALLEN; HUGHES ROBERT MICHAEL
权利人:CIDARA THERAPEUTICS INC
摘要:The present invention relates to intermediates and methods for synthesizing protein-drug conjugates that can be used for the treatment of diseases and related conditions.

专利号:US-6204361-B1
优先权日:1996-01-18
标 题 :Method of peptide synthesis
发明人:CARPINO LOUIS A; IONESCU DUMITRU
权利人:RES CORP TECHNOLOGIES INC
摘要:The present invention relates to a process for forming an N-α-amino protected amino acid fluoride in situ by reacting an N-α-amino protected amino acid with an ionic fluoride salt in the presence of a peptide coupling agent. It is also directed to the use of the amino acid fluoride thus formed in peptide synthesis.

专利号:US-9783490-B2
优先权日:2012-12-18
标 题:Antimicrobial compounds, their synthesis and applications thereof
发明人:HALDAR JAYANTA; GHOSH CHANDRADHISH; MANJUNATH GOUTHAM BELAGULA; AKKAPEDDI PADMA
权利人:THE SEC DEP FOR HEALTH; JAWAHARLAL NEHRU CENTER FOR ADVANCED SCIENT RES; JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENT RES
摘要:The present disclosure relates to the field of medicinal chemistry and more particularly to the development of antimicrobial compounds. The disclosure relates to the synthesis and characterization of compounds comprising aromatic radical or an aliphatic radical, an alkyl amine and amino acid moiety wherein said compounds exhibit antimicrobial activity against various drug-sensitive and drug-resistant pathogenic 10 microorganisms.

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✅ COA系统入驻 | 共享模式

主要参考文献

1. Sugawara M, Nakanishi T, Fei YJ, Martindale RG, Ganapathy ME, Leibach FH, Ganapathy V. Structure and function of ATA3, a new subtype of amino acid transport system A, primarily expressed in the liver and skeletal muscle. Biochim Biophys Acta. 2000 Dec 20;1509(1-2):7-13. doi: 10.1016/s0005-2736(00)00349-7. 23(7):536-41. doi: 10.1053/plac.2002.0839.

合成参考文献


参考文献:10.1113/jphysiol.2011.207175
摘要:Hamdi MM, Mutungi G. Dihydrotestosterone stimulates amino acid uptake and the expression of LAT2 in mouse skeletal muscle fibres through an ERK1/2‐dependent mechanism. The Journal of Physiology. 2011 Jul 15;589(14):3623–40. doi: 10.1113/jphysiol.2011.207175.
参考文献:10.1007/s00726-017-2384-7
摘要:Takahashi Y, Nishimura T, Maruyama T, Tomi M, Nakashima E. Contributions of system A subtypes to α-methylaminoisobutyric acid uptake by placental microvillous membranes of human and rat. Amino Acids. 2017 Apr;49(4):795–803. doi: 10.1007/s00726-017-2384-7.
参考文献:10.1007/bf00231811
摘要:Taylor PM, Mackenzie B, Hundal HS, Robertson E, Rennie MJ. Transport and membrane binding of the glutamine analogue 6-diazo-5-oxo-L-norleucine (DON) in Xenopus laevis oocytes. The Journal of Membrane Biology. 1992 Jun;128(3):181–91. doi: 10.1007/bf00231811.
参考文献:10.1007/s004240050257
摘要:Kudo Y, Iwashita M, Iguchi T, Takeda Y. The regulation of type-I collagen synthesis by insulin-like growth factor-I in human osteoblast-like SaOS-2 cells. Pflgers Archiv European Journal of Physiology. 1996 Nov 18;433(1-2):123–8. doi: 10.1007/s004240050257.
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