CAS: 2552-55-8; 2-Amino-2-(3-Oxo-2,3-Dihydroisoxazol-5-yl)Acetic Acid

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CAS号2552-50-3 (3-benzyloxy-is... | CAS号2552-49-0 (3-benzyloxy-is...

📜(3-Benzyloxy-Isoxazol-5-yl)-(Toluene-4-Sulfonyloxy)-Acetic Acid Ethyl Ester置于sodium Bromide体系中,用 二甲基亚砜 用作溶剂,化学反应生成鹅膏氨酸
参考文献:Synthesis Of Ibotenic Acid
标题:Synthesis Of Ibotenic Acid
摘要:
Doi:10.1016/s0040-4039(00)90158-8

专利信息

专利号:US-5338851-A
优先权日:1993-03-31
标 题:Synthesis of cis-decahydroisoquinoline-3-carboxylic acids
发明人：HUFF BRET E; KHAU VIEN V; MARTINELLI MICHAEL J; PETERSON BARRY C
权利人:LILLY CO ELI
摘要:This invention provides a process for the synthesis of cis-decahydroisoquinoline-3-carboxylic acids and provides intermediates in the synthesis thereof.

专利号:US-5591867-A
优先权日:1992-12-04
标 题 :Synthesis of kainic acid
发明人：MONN JAMES A
权利人:LILLY CO ELI
摘要:This invention provides a process for preparing kainic acid and provides intermediates in the synthesis thereof.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:EP-1360308-B1
优先权日:2001-01-25
标题 :Concatemers of differentially expressed multiple genes
发明人：GOLDSMITH NEIL; SORENSEN ALEXANDRA M P SANTANA; NIELSEN SOREN V S; NAESBY MICHAEL
权利人:EVOLVA LTD
摘要:In the present invention are disclosed concatemers of concatenated expression cassettes and vectors that enable the synthesis of such concatemers. The concatemer comprises in the 5' ->3' direction a cassette of nucleotide sequence of the general formula [rs2-SP-PR-X-TR-SP-rs1]n wherein rs1 and rs2 together denote a functional restriction site, SP individually denotes a spacer of at least two nucleotide bases, PR denotes a promoter, capable of functioning in a cell, X denotes an expressible nucleotide sequence, TR denotes a terminator, and SP individually denotes a spacer of at least two nucleotide bases, and n >/= 2, and wherein at least a first cassette is different from a second cassette. The main purpose of these concatemers is the controllable and co-ordinated expression of large numbers of heterologous genes in a single host. Furthermore, the invention relates to a concatemer of cassettes of nucleotide sequences and a method for preparing the concatemers. In a further aspect, the invention relates to transgenic host cells comprising at least one concatemer according to the invention, as well as to a method for preparing the transgenic host cells. Finally, the invention relates to a vector comprising a cassette of nucleotides, a method for preparing said vector, a nucleotide library comprising at least two primary vectors each comprising a cassette of nucleotides, a method for preparing the library.

专利号:US-8008459-B2
优先权日:2001-01-25
标 题 :Concatemers of differentially expressed multiple genes
发明人：GOLDSMITH NEIL; SORENSEN ALEXANDRA M P SANTANA; NIELSEN SOREN V S; NAESBY MICHAEL
权利人:EVOLVA SA
摘要:In the present invention are disclosed concatemers of concatenated expression cassettes and vectors that enable the synthesis of such concatemers. The concatemer comprises in the 5′→3′ direction a cassette of nucleotide sequence of the general formula [rs2-SP-PR-X-TR-SP-rs1]n wherein rs1 and rs2 together denote a functional restriction site, SP individually denotes a spacer of at least two nucleotide bases, PR denotes a promoter, capable of functioning in a cell, X denotes an expressible nucleotide sequence, TR denotes a terminator, and SP individually denotes a spacer of at least two nucleotide bases, and n>/=2, and wherein at least a first cassette is different from a second cassette. The main purpose of these concatemers is the controllable and co-ordinated expression of large numbers of heterologous genes in a single host. Furthermore, the invention relates to a concatemer of cassettes of nucleotide sequences and a method for preparing the concatemers. In a further aspect, the invention relates to transgenic host cells comprising at least one concatemer according to the invention, as well as to a method for preparing the transgenic host cells. Finally, the invention relates to a vector comprising a cassette of nucleotides, a method for preparing said vector, a nucleotide library comprising at least two primary vectors each comprising a cassette of nucleotides, a method for preparing the library.

专利号:US-6096893-A
优先权日:1999-08-16
标题 :Process and intermediates for 3-heteroaryl-4(3H) quinazolines
发明人：DEVRIES KEITH M
权利人:PFIZER
摘要:A new pyridine carbaldehyde is useful for the synthesis of compounds which are effective for treating neurodegeneration conditions and CNS trauma.