CAS: 2458-12-0; 3-Amino-4-Methylbenzoic Acid

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CAS号96-98-0 4-甲基-3-硝基苯甲酸 | CAS号6946-14-1 3-乙酰胺基-4甲基苯甲酸 | CAS号60710-80-7 3-氨基-4-甲基苯腈 | CAS号4478-10-8 2-溴-1-异丙基-4-甲基苯 | CAS号859816-42-5 1-bromo-2-isopr... | CAS号861525-09-9 acetic acid-(5-... | CAS号99-94-5 对甲基苯甲酸 | CAS号90178-80-6 4-(chloromethyl... | CAS号874-86-2 4-氰基苄氯 | CAS号7647-01-0 盐酸 | CAS号1061314-04-2 5-溴-2-氯-4-(甲氧基羰基)苯甲酸 | CAS号56525-63-4 3-氯-4-甲基苯甲酸甲酯 | CAS号141368-92-5 [(3-amino-4-met... | CAS号916902-55-1 1H-吲唑-6-甲醇 | CAS号41191-92-8 3-氨基-4-甲基苯甲酸乙酯 | CAS号5162-82-3 3-氯-4-甲基苯甲酸 | CAS号82998-57-0 3-碘-4甲基苯甲酸 | CAS号231958-04-6 3-((叔丁氧基羰基)氨基)-... | CAS号704-91-6 1H-吲唑-6-羧酸 | CAS号6946-14-1 3-乙酰胺基-4甲基苯甲酸

4-甲基-3-硝基苯甲酸置于ammonium Hydroxide,硫化氢体系中,化学反应生成3-氨基-4-甲基苯甲酸
参考文献:微生物的代谢产物.第101部分.的合成反式-5-羟基-3-Methylpentene-(2)-酸(反式-δ 2-Anhydromevalonic酸)
标题:微生物的代谢产物.第101部分.的合成反式-5-羟基-3-Methylpentene-(2)-酸(反式-δ 2-Anhydromevalonic酸)
摘要:反式-δ 2-Anhydromevalonic酸(xvii)用制备维悌希反应,从(4-四氢-2-吡喃基)-2-丁酮开始.另一方面,在相似的条件下,相应的4-乙酰氧基-2-丁酮产生了环己烯衍生物v,这可以通过将wittig试剂两次迈克尔加成到甲基乙烯基酮上,然后进行分子内醇缩合来解释.
Doi:10.1002/hlca.19720550123

专利信息

专利号:US-11649213-B2
优先权日:2018-09-26
标题 :Synthetic method for the preparation of a 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol compound
发明人：MEISENBACH MARK; MARTIN BENJAMIN; RONDE NIEK JOHANNES; RUIZ CARMEN
权利人:MEREO BIOPHARMA 1 LTD
摘要:Provided is a process for preparing a compound, comprising the steps of a) Reacting a compound of Formula A (Formula A) with the compound 3 (3) to provide the compound 5 (5) or a salt or solvate thereof, wherein R is a linear or branched C1-C5 alkyl. Further provided is the compound 5 or a salt or solvate thereof. (5) The use of these compounds in the synthesis of 3-[5-Amino-4-(3-Cyanobenzoyl)-Pyrazol-1-yl]-N-Cyclopropyl-4-Methylbenzamide is also provided.

专利号:US-12441733-B2
优先权日:2018-03-26
标题:Substituted 2,4-dioxotetrahydropyrimidines as intermediates in the synthesis of bruton's tyrosine kinase inhibitors
发明人：ARISTA LUCA; HEBACH CHRISTINA; HOLLINGWORTH GREGORY JOHN; HOLZER PHILIPP; IMBACH-WEESE PATRICIA; LORBER JULIEN; MACHAUER RAINER; SCHMIEDEBERG NIKO; VULPETTI ANNA; ZOLLER THOMAS
权利人:NOVARTIS AG
摘要:The invention relates to compounds of the formulae (I), (III), (IIIa), (XXIa), (XXIII), and/or (XLVI)or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to use of the compounds in the treatment of disease.

专利号:US-2024400552-A1
优先权日:2016-11-11
标题 :Heterocyclic modulators of lipid synthesis
发明人：BUCKLEY DOUGLAS I; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
权利人:SAGIMET BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by dysregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

专利号:US-11622968-B2
优先权日:2011-03-08
标 题:Heterocyclic modulators of lipid synthesis
发明人：BUCKLEY DOUGLAS; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
权利人:SAGIMET BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

专利号:US-11034690-B2
优先权日:2016-11-11
标 题:Heterocyclic modulators of lipid synthesis
发明人：BUCKLEY DOUGLAS I; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
权利人:SAGIMET BIOSCIENCES INC; SAGINIET BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

专利号:US-9809591-B2
优先权日:2011-03-08
标题 :Heterocyclic modulators of lipid synthesis
发明人：OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W
权利人:3-V BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders.