CAS: 23138-50-3; 1-Ethyl-4-Isocyanatobenzene

该化合物是一种有机化合物,附于一个苯环的异氰酸性功能组,在准位置以乙基组替代,该化合物通常用作聚氨酯,涂料,粘合剂和其他特殊化学品的合成中的一种反应中间体,其异氰酸盐组可与含有氢氧的化合物高效交叉连接,形成耐久的聚乙烷联系;乙基替代替代品影响活性和溶解性,在聚合工艺中提供量身定制的性能;由于其稳定性和受控的再活性,1-乙基-4-异丙氮苯在需要精确化学修改的工业应用中被估价为1-乙基-4-异丙烷苯.

结构式图片

欧盟法规

ECHA物质ECHA物质C&L通报REACH预注册

上下游产品

bis(trichloromethyl) carbonate 4-aminoethylbenzene ethyl 2-hydroxy-3-methyl-3-butenoate 2'-amino-4-ethylbiphenyl 1-(4-Ethyl-phenyl)-3-(1-methyl-1-phenyl-ethyl)-urea (4-Ethyl-phenyl)-carbamic acid 2-piperidin-1-yl-ethyl ester; hydr°Chloride (4-ethyl-phenyl)-carbamic acid 2-(4-dibenzylsulfamoyl-phenyl)-2-oxo-ethyl ester

合成工艺路线路线简述

  • 合成目标产物 4-Ethylphenyl Isocyanate 主要起始原料 Triphosgene And 4-Ethylaniline
  • (文献来源)合成步骤主要原料 Triphosgene 和 4-Ethylaniline
三光气,4-乙基苯胺 以 二氯甲烷 用作溶剂,化学反应 0.5H,反应生成4-乙基苯基异氰酸酯
参考文献:三乙胺还原中间体异氰酸酯简单高效合成二芳基脲
标题:三乙胺还原中间体异氰酸酯简单高效合成二芳基脲
摘要:从芳胺和三光气以三乙胺作为中间体异氰酸酯的还原剂合成了三十种对称的二芳基脲衍生物,收率中等至极好.重要的是,部分产物可以在没有柱色谱的情况下以几乎定量的收率收集.在温和的反应条件下,该过程可以容忍广泛的官能团.化合物的结构通过NMR,Ms和x-射线晶体学分析确定.
Doi:10.3184/174751913X13663925002708

海关参考信息

专利信息


专利号:US-9879050-B2
优先权日:2013-08-30
标 题 :Substituted urea depsipeptide analogs as activators of the CLPP endopeptidase
发明人:LEE RICHARD E; ZHAO YING; GRIFFITH ELIZABETH; ZHENG ZHONG; SINGH AMAN P
权利人:ST JUDE CHILDREN'S RES HOSPITAL
摘要:In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators the ClpP endopeptidease; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating infectious disease using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:CN-111471171-B
优先权日:2019-01-24
标 题:A kind of aryl sulfonic acid intermediate and its preparation method, and its application for the synthesis of low temperature sensitive admixture for concrete

专利号:US-10570179-B2
优先权日:2016-09-02
标 题:Substituted urea depsipeptide analogs as activators of the CLPP endopeptidase
发明人:LEE RICHARD E; ZHAO YING
权利人:ST JUDE CHILDRENS RES HOSPITAL
摘要:In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators the ClpP endopeptidease; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating infectious disease using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:US-10822377-B2
优先权日:2015-03-04
标 题:Substituted urea depsipeptide analogs as activators of the ClpP endopeptidase
发明人:LEE RICHARD E; ZHAO YING; JIUYU LIU
权利人:ST JUDE CHILDRENS RES HOSPITAL
摘要:In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators the ClpP endopeptidease; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating infectious disease using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:EP-0789577-A1
优先权日:1995-06-07
标 题:Synthesis of n-substituted oligomers

专利号:WO-9640202-A1
优先权日:1995-06-07
标 题:Synthesis of n-substituted oligomers
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合成参考文献


参考文献:10.1021/la702620c
摘要:Kato R, Liauw CM, Allen NS, Irure A, Wilkinson AN, Stanford JL, Fithriyah NH. Interfacial interactions in polymer-layered silicate nanocomposites. Langmuir. 2008 Mar 04;24(5):1943–51. doi: 10.1021/la702620c.
参考文献:10.1007/s11356-021-14834-1
摘要:Fu J, Wang L, Chen Y, Yan D, Ou H. Enhancement of aqueous stability of NH2-MIL-101(Fe) by hydrophobic grafting post-synthetic modification. Environmental Science and Pollution Research. 2021 Jul 17;28(48):68560–71. doi: 10.1007/s11356-021-14834-1.
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