专利号:US-11059835-B2 优先权日:2014-08-15 标 题 :Synthesis of cephalosporin compounds 发明人:WALLER DAVID; GAZDA GREGORY; MINDEN ZACHARY; BARTON LISA; LEIGH CLIFTON 权利人:MERCK SHARP & DOHME 摘要:Provided herein is a method for the synthesis of cephalosporin antibiotic compounds comprising a palladium-catalyzed coupling reaction.
专利号:US-5703201-A 优先权日:1995-10-10 标题:Catalyst for polymerization of polyketone formed by treatment with carbon monoxide and olefin 发明人:HANNA PAUL K 权利人:AKZO NOBEL NV 摘要:A process for the synthesis of a catalyst for the polymerization of carbon monoxide and at least one olefin which comprises treating a mixture of a compound of palladium, such as tetrakis(acetonitrile) palladium, and a Lewis acid anion, such as a fluoride of a metal selected from Group III to Group V of the Periodic Table (e.g., boron trifluoride), with carbon monoxide and an olefin followed by reaction of the resulting composition with a bidentate ligand reagent, such as a 1,3-bis(diphenyl-phosphino) alkane (e.g., 1,3-bis(diphenyl-phosphino) propane).
专利号:US-10457640-B2 优先权日:2016-10-19 标 题:Synthesis of inhibitors of EZH2 发明人:VASWANI RISHI G; HEWITT MICHAEL CHARLES 权利人:CONSTELLATION PHARMACEUTICALS INC 摘要:Provided herein are synthetic methods for the preparation of EZH2 inhibitors.
专利号:US-7071314-B2 优先权日:2001-05-30 标题:Arylation method for the functionalization of O-allyl erythromycin derivatives 发明人:ZHANG WEIJANG; HSU MARGARET CHI-PING; HAIGHT ANTHONY R; PETERSON MATTHEW JOHN; NARAYANAN BIKSHANDARKOIL A 权利人:ABBOTT LAB 摘要:An efficient arylation technique for use in the synthesis of erythromycin derivatives, involving a modified Heck reaction which employs less than six mole percent of palladium catalyst and no phosphine is disclosed. With this modified Heck reaction, an O-alkenylaryl macrolide can be obtained in a much shorter reaction time than under conventional Heck reaction conditions. The modified Heck reaction can be utilized in a method for phosphine-free arylation of an O-allylic erythromycin derivative, in a method for preparing an O-alkenylaryl erythromycin A derivative, or in a method for preparing a 2′, 4″-hydroxyl protected 6-O-alkenylaryl erythromycin A derivative.
专利号:US-2019233375-A1 优先权日:2016-10-19 标题:Synthesis of inhibitors of ezh2
专利号:EP-3180347-B1 优先权日:2014-08-15 标 题:Synthesis of cephalosporin compounds
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