CAS: 1721-23-9; 3-Cyano-2-Methylpyridine

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3222-56-8 60032-57-7 58539-65-4

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📜6-氯-2-甲基-3-氰基吡啶置于5%-Palladium/activated Carbon,甲酸铵体系中,用 甲醇 用作溶剂,化学反应 12.0H,以81%的收率获得3-氰基-2-甲基吡啶
参考文献:与苯并[c]菲啶骨架的一步合成进入等位和有效的抗癌氮杂环
标题:与苯并[c]菲啶骨架的一步合成进入等位和有效的抗癌氮杂环
摘要:描述了一种通用的一步式两组分环化反应,可构建新的四环氮杂环.将邻甲基甲基戊烯腈成分与醛缩合,以访问一个由大量不同取代的环系统组成的库.通过改变环内氮原子在邻位的位置,可以很容易地修饰杂环核-甲基戊烯甲腈底物.导致缩合的亲核攻击方式可以由氮原子位置引起的分子中不同的电子密度分布来触发.考虑到这一点,存在电子偏好,其导致以吡啶并菲咯啉或相应的吡啶并氮杂咔唑为主要产物.我们证明了某些合成杂环具有很高的抗肿瘤潜力,这在很大程度上取决于通过醛组分引入的取代模式.内环氮原子的位置和数量在所研究化合物的细胞毒性方面起着重要作用.
Doi:10.1002/chem.201600308

专利信息

专利号:US-8772301-B2
优先权日:2009-12-18
标题 :Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof
发明人：HARDY LARRY WENDELL; HEFFERNAN MICHELE L R; WU FRANK XINHE; SPEAR KERRY L; SARASWAT LAKSHMI D
权利人:HARDY LARRY WENDELL; HEFFERNAN MICHELE L R; WU FRANK XINHE; SPEAR KERRY L; SARASWAT LAKSHMI D; SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are compounds and methods of synthesis thereof. The compounds set forth herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders, neurodegenerative disorders, neuropsychiatric disorders, disorders of cognition, learning or memory, gastrointestinal disorders, lower urinary tract disorder, and cancer. Compounds set forth herein modulate the activity of metabotropic glutamate receptor 5 (mGluR5) in the central nervous system or the periphery. Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.

专利号:US-2020216836-A1
优先权日:2005-12-01
标题 :Enzymatic encoding methods for efficient synthesis of large libraries

专利号:US-2019330618-A1
优先权日:2005-12-01
标题 :Enzymatic encoding methods for efficient synthesis of large libraries

专利号:US-3862191-A
优先权日:1972-09-27
标 题 :Pyrido{8 2,3-d{9 pyrimidin-4(3H)-one
发明人：EL-HAJ MARWAN J ABU; DOMINY BERYL WILLIAM
权利人:PFIZER
摘要:2-Substituted pyridopyrimidines and their alkali and alkylamine salts as herbicides, and processes for the synthesis of starting materials leading to the preparation thereof.

专利号:US-5403845-A
优先权日:1991-08-27
标 题:Muscarinic agonists
发明人：DUNBAR PHILIP G; DURANT GRAHAM J; HOSS WAYNE P; MESSER JR WILLIAM S
权利人:UNIV TOLEDO
摘要:Substituted 1,4,5,6 -tetrahydropyrimidine compositions, substituted 1,2,3,6 -tetrahydropyrimidine compositions and substituted 3,4,5,6 -tetrahydropyridine compositions are disclosed. They are useful for stimulating muscarinic receptors including, for example, treating the symptoms of cognitive disorders, especially impaired memory, which are associated with decreased acetylcholine synthesis and cholinergic cell degeneration.