CAS: 154825-97-5; Methyl 2-(4-Bromophenyl)-2,2-Dimethylacetate

相似化合物

32454-35-6 32454-16-3 32454-37-8

上下游产品

2-(4-溴苯基)丙酸甲酯 Methyl 2-(4-Bromophenyl)Propanoate 83636-46-8
2-(4-溴苯基)-2-甲基丙酸 2-(4-Bromophenyl)-2-Methylpropanoic Acid 32454-35-6
4-溴苯乙酸甲酯 (4-Bromo-Phenyl)-Acetic Acid Methyl Ester 41841-16-1
对溴苯乙酸 2-(4-Bromophenyl)-Acetic Acid 1878-68-8

2-溴代异丁酸甲酯置于三甲基氯硅烷,4,5-双二苯基膦-9,9-二甲基氧杂蒽,Bis(Dibenzylideneacetone)-Palladium(0)体系中,用 四氢呋喃 用作溶剂,化学反应 3.25H,反应生成2-(4-溴苯基)-2,2-二甲基乙酸甲酯
参考文献:A Chemoselective Reformatsky-negishi Approach To α-Haloaryl Esters
标题:A Chemoselective Reformatsky-negishi Approach To α-Haloaryl Esters
摘要:A Practical Synthesis Of Alpha-Haloaryl Esters Has Been Achieved Via A Chemoselective Negishi Coupling Of Poly-Halogenated Aromatics And Reformatsky Reagents In The Presence Of Catalytic Pd(Dba)(2) And Xantphos. This Chemistry Tolerates A Variety Of Aryl Halides And Was Successfully Applied To The Synthesis Of Ibuprofen. The Alpha-Haloaryl Ester Products,Exemplified By Ethyl 2-(4-Bromo-2-Chlorophenyl)Acetate (3A),Can Be Further Functionalized Via Palladium Or Copper Catalysis To Afford An Array Of A-Aryl Esters. (C) 2014 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Tet.2013.12.053