CAS: 1509-35-9; H-D-Allo-Ile-Oh

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319-78-8 443-79-8 73-32-5

上下游产品

D-Isoleucine D,L-β-methylenenorvaline 2-Azido-3-methyl-pentanoic acid 2-oxo-3(RS)-methylvaleric acid2-Methylbutyraldehyde L-isoleucine 1-chloro-2-methylbutanecarboxylic acid 2-Amino-3-methyl-pentanoic acid methyl ester

3-甲基-2-氧基戊酸置于meso-2,6-D-Diaminopimelic Acid Dehydrogenase Mutant Bc621,氯化铵,还原型辅酶ii(Nadph)四钠盐体系中,用 Various Solvent(S) 用作溶剂,化学反应 24.0H,反应生成D-别异亮氨酸
参考文献:Creation Of A Broad-Range And Highly Stereoselective D-Amino Acid Dehydrogenase For The One-Step Synthesis Of D-Amino Acids
标题:Creation Of A Broad-Range And Highly Stereoselective D-Amino Acid Dehydrogenase For The One-Step Synthesis Of D-Amino Acids
摘要:Using Both Rational And Random Mutagenesis,We Have Created The First Known Broad Substrate Range,Nicotinamide Cofactor Dependent,And Highly Stereoselective D-Amino Acid Dehydrogenase. This New Enzyme Is Capable Of Producing D-Amino Acids Via The Reductive Amination Of The Corresponding 2-Keto Acid With Ammonia. This Biocatalyst Was The Result Of Three Rounds Of Mutagenesis And Screening Performed On The Enzyme Meso-Diaminopimelate D-Dehydrogenase. The First Round Targeted The Active Site Of The Wild-Type Enzyme And Produced Mutants That Were No Longer Strictly Dependent On The Native Substrate. The Second And Third Rounds Produced Mutants That Had An Increased Substrate Range Including Straight-And Branched-Aliphatic Amino Acids And Aromatic Amino Acids. The Very High Selectivity Toward The D-Enantiomer ( 95 To > 99% Ee) Was Shown To Be Preserved Even After The Addition Of The Five Mutations Found In The Three Rounds Of Mutagenesis And Screening. This New Enzyme Could Complement And Improve Upon Current Methods For D-Amino Acid Synthesis.
Doi:10.1021/ja0603960

专利信息

专利号:US-12351573-B2
优先权日:2019-05-09
标 题:Compounds for use in synthesis of peptidomimetics
发明人：AL-ABED YOUSEF; CHENG KAI FAN
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Synthesis of O-benzotriazole and O-imidazole synthons are described. Uses of synthons in synthesis of azapeptides and other peptidomimetics, azapeptides and other peptidomimetics synthesized from the synthons and uses of azapeptides and other peptidomimetics are also described.

专利号:US-2023159450-A1
优先权日:2020-05-08
标 题 :Dimers for use in synthesis of peptidomimetics
发明人：AL-ABED YOUSEF; ALTITI AHMAD
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Dimers for use in synthesis of peptidomimetics are described. Uses of dimers as synthons in synthesis of azapeptides and other peptidomimetics, azapeptides and other peptidomimetics synthesized from the dimers and uses of azapeptides and other peptidomimetics are also described.

专利号:US-2020354404-A1
优先权日:2019-05-09
标 题 :Peptidomimetic agents, synthesis and uses thereof
发明人：AL-ABED YOUSEF
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Compounds for use in synthesis of peptidomimetic agents; synthesis of peptidomimetic agents; peptidomimetic diagnostic and therapeutic agents; and uses of the compounds and peptidomimetic agents in drug discovery, diagnosis, prevention and treatment of diseases are described.

专利号:WO-2025128985-A1
优先权日:2023-12-14
标题 :Sulfoxide and sulfone derivatives of thiocarbazates as synthons for azapeptides synthesis and process of using same
发明人：AL-ABED YOUSEF
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Provided for herein are sulfoxide and sulfone derivatives of thiocarbazates that have the formula (I): wherein A, R, R 1 , R 2 , and n are defined herein. The compounds may be used as synthons in the synthesis of azaeptides and other aza- amino acid conjugates.

专利号:US-2022356484-A1
优先权日:2019-09-06
标 题:Genetic modification of plants
发明人：BERMAN JAMES
权利人:BERMAN DR JAMES
摘要:Gene editing complexes are specifically directed to cannabinoid sequences, such as tetrahydrocannabinol (THC), for excision or inactivation of these sequences. The disclosure is directed to the inhibition of synthesis of THC in a cannabis plant. In doing so, THC would never become an active compound within the plant chemistry and chemotype, thereby eliminating the chance of CBD extracts being contaminated with THC.

专利号:US-10370409-B2
优先权日:2011-10-25
标题 :Synthesis of libraries of peptide tertiary amides
发明人：KODADEK THOMAS; GAO YU
权利人:SCRIPPS RESEARCH INST
摘要:The present disclosure is directed to a novel class of peptide-like oligomers called peptide tertiary amides (PTAs) and a combinatorial library of PTAs along with synthetic routes for the preparation of large combinatorial libraries of these compounds. The peptide tertiary amides provide an exceptional source of high affinity and selective protein ligands that are useful as tools for biological research and as drug leads, among others.