CAS: 133737-32-3; Pagoclone

该化合物是属于厌食类的化学化合物,主要因其在治疗焦虑症方面的潜在用途而受到调查;它是GABA-A受体的选择性调制器,是中...

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      专利号:WO-2009087650-A2
      优先权日:2007-10-15
      标题 :A novel process for synthesis of pregabalin from substituted cyclopropane intermediate and a process for enzymatic resolution of racemic pregabalin

      专利号:CN-114394926-A
      优先权日:2022-02-28
      标题:High Yield Synthesis of N,3-Disubstituted-1-isoindolinones

      专利号:CN-110467558-A
      优先权日:2019-08-08
      标题:A kind of reaction method of nickel-catalyzed synthesis of 3-amino isoindolinone

      专利号:CN-114539124-A
      优先权日:2022-02-28
      标题 :A method for enantioselective synthesis of N,3-disubstituted-1-isoindolinone compounds

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      主要参考文献


      1: Kronstrand R, Roman M, Johansson A, Wu X, Green H, Truver MT. Rilmazafone: A designer benzodiazepine pro-drug involved in fatal intoxications. J Anal Toxicol. 2023 Sep 15;47(7):640-643. doi: 10.1093/jat/bkad041. 19(26):5876-5887. doi: 10.1039/d1ob00656h. Erratum in: Org Biomol Chem. 2021 Jul 7;19(26):5914. doi: 10.1039/d1ob90092g. 21(5):1273-1277. doi: 10.1021/acs.orglett.8b04026. Epub 2019 Feb 12. 30(5):649-50; author reply 650-1. doi: 10.1097/JCP.0b013e3181f1f130. 32(5):331-88. doi: 10.1358/mf.2010.32.5.1520420. 30(1):48-56. doi: 10.1097/JCP.0b013e3181caebbe. 4(1):277-82. doi: 10.2147/ndt.s2351.
      8: Bayes M. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2007 Mar;29(2):153-73. 26(3):268-73. doi: 10.1097/01.jcp.0000218983.61683.96. 50(6):677-89. doi: 10.1016/j.neuropharm.2005.11.014. Epub 2006 Jan 20. 180(4):789-91. doi: 10.1007/s00213-005-0060-1. Epub 2005 Sep 14. 14(5):601-18. doi: 10.1517/13543784.14.5.601. 26(3):211-44. 2(4):213-32. doi: 10.2174/1568007033482841. 4(1):91-5. 15(3):205-8. doi: 10.1177/026988110101500312.

      合成参考文献


      参考文献:10.1186/s12871-019-0799-2
      摘要:Schäfer P, Fahlenkamp A, Rossaint R, Coburn M, Kowark A. Better haemodynamic stability under xenon anaesthesia than under isoflurane anaesthesia during partial nephrectomy – a secondary analysis of a randomised controlled trial. BMC Anesthesiology. 2019 Jul 09;19(1):125. doi: 10.1186/s12871-019-0799-2.
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