CAS: 117-37-3; 2-(4-Methoxyphenyl)-1H-Indene-1,3(2H)-Dione

该化合物是一种合成有机化合物,被归类为丙氨酸衍生物;它看起来像白色的黄色晶状黄粉粉,以其抗凝胶特性著称,在医疗领域作为抗凝胶剂有用;该化合物的特征是,它能够抑制维生素K聚氧氧化还原酶,因为它在肝脏凝聚因子合成中发挥着关键作用;亚尼辛迪酮在乙醇和丙酮等有机溶剂中溶解,但水溶性有限;其化学结构具有1,3-二苯胺的特性,有助于其再活性和生物活动;阿尼辛迪酮通常通过口服,并因其潜在副作用,包括出血并发症,受到认真监测;与许多抗cougul剂一样,其使用需要考虑到病人特有的因素,包括其他药物和基本健康状况;

结构式图片

物理性质

MSDS等安全信息

欧盟法规

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上下游产品

CAS号87-41-2 苯酞 | CAS号123-11-5 4-甲氧基苯甲醛; 对甲氧基苯... | CAS号1807-49-4 1,3-Indandione,... | CAS号100-66-3 苯甲醚 | CAS号104-47-2 对甲氧基苯乙腈 | CAS号5219-04-5 [1-cyano-1-(4-m... | CAS号93-58-3 苯甲酸甲酯 | CAS号93-89-0 苯甲酸乙酯 | CAS号131-11-3 邻苯二甲酸二甲酯； 避蚊酯 | CAS号3312-38-7 2-(4-methoxyphe... | CAS号1217-32-9 1H-Indene-1,3(2...

合成工艺路线路线简述

  • 合成目标产物 2-P-Anisyl-1,3-Indandione 主要起始原料 Phthalide And P-Anisaldehyde
  • (文献来源)合成步骤主要原料 Phthalide 和 P-Anisaldehyde
📜3-[(4-甲氧基苯基)亚甲基]苯酞置于乙醇,Sodium Ethanolate体系中,化学反应生成茴茚二酮
参考文献:Horeau; Jacques,Bulletin De La Societe Chimique De France,1948,P. 53,58
标题:Horeau; Jacques,Bulletin De La Societe Chimique De France,1948,P. 53,58

海关参考信息

专利信息


专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:US-10814013-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

专利号:AU-2007308022-A2
优先权日:2006-10-05
标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

专利号:AU-2007308022-A1
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

专利号:US-2008107598-A1
优先权日:2006-10-05
标 题:Efficient Synthesis of Chelators for Nuclear Imaging and Radiotherapy: Compositions and Applications

专利号:AU-2007308022-B2
优先权日:2006-10-05
标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

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主要参考文献


1: Grosset AB, Allen JE, Rodgers GM. Anticoagulation with anisindione in patients who are intolerant of warfarin. Am J Hematol. 1994 Jun;46(2):138-40. doi: 10.1002/ajh.2830460215. 55(1):73-9. doi: 10.1016/0002-8703(58)90257-6. 80(10):785-90.
4: Spyropoulos AC, Hayth KA, Jenkins P. Anticoagulation with anisindione in a patient with a warfarin-induced skin eruption. Pharmacotherapy. 2003 Apr;23(4):533-6. doi: 10.1592/phco.23.4.533.32130. 18(8):348-355. doi: 10.1089/adt.2020.1010. Epub 2020 Nov 6.
6: BUZZI A, CARBAJAL B. [Clinical evaluation of the anticoagulant, anisindione]. Prensa Med Argent. 1961 Jun 23;48:1826-9. Spanish.

合成参考文献


参考文献:10.1007/s00415-011-6153-3
摘要:Cervera A, Amaro S, Chamorro A. Oral anticoagulant-associated intracerebral hemorrhage. J Neurol. 2012 Feb;259(2):212–24. doi: 10.1007/s00415-011-6153-3.
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