CAS: 1126-74-5; 3-(Pyridin-3-yl)Acrylic Acid

相似化合物

19337-97-4 120277-39-6 59607-99-7

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3-pyridinecarboxaldehyde malonic acid acetic anhydride 3-(3-pyridinyl)-2-propenenitrile 3-(piperidin-3-yl)propionic acid 3-pyridine propionic acid 3-amino-3-(pyridin-3-yl)propanoic acid (E)-3-(pyridin-3-yl)acrylamide

3-Pyridin-3-Yl-Acrylic Acid Butyl Ester置于potassium Hydroxide体系中,用 乙醇,水 用作溶剂,化学反应 3.0H,以98%的收率获得3-(3-吡啶)丙烯酸
参考文献:一种新型nampt和ido双重抑制剂及其制 备方法和医药用途
标题:一种新型nampt和ido双重抑制剂及其制 备方法和医药用途
摘要:本发明公开了一种新型nampt和ido双重抑制剂及其制备方法和医药用途,具体涉及一种呋咱类化合物或其药学上可接受的盐,溶剂化物,前药,酯,外消旋体和异构体和含有这类化合物的药物组合物以及这些化合物或药物组合物在制备抗肿瘤药物中的应用.本发明将ido抑制剂和nampt抑制剂的活性片段进行合理拼接得到了呋咱类ido/nampt双靶点抑制剂,一方面双重抑制了nad+的生物合成,从而表现出更强的肿瘤抑制活性;另一方面ido活性的抑制可以有效地促进t细胞的增殖,从而增强机体对肿瘤细胞的攻击能力.这类呋咱类ido/nampt双靶点抑制剂或其药物组合物具有广阔的应用前景,有望成为抗肿瘤药物.

专利信息

专利号:US-7109377-B2
优先权日:1996-10-16
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
发明人：SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R
权利人:HARVARD COLLEGE
摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.

专利号:US-8771639-B2
优先权日:2007-01-05
标 题 :Methods for preparing composites of substrate-molecular sieve
发明人：YOON KYUNG BYUNG; LEE JIN SEOK; KIM JAE HYUN; LEE YOUNG JU; JEONG NAK CHEON
权利人:YOON KYUNG BYUNG; LEE JIN SEOK; KIM JAE HYUN; LEE YOUNG JU; JEONG NAK CHEON; UNIV SOGANG IND UNIV COOP FOUN
摘要:The present invention relates to a method for preparing composites of substrate-molecular sieve, in particular, to a method for preparing a composite of substrate-molecular sieve, which comprises applying a physical pressure to molecular sieve crystals against a substrate to form a chemical bond between the molecular sieve crystal and the substrate. The present invention requiring no solvents, reactors and other equipments enables molecular sieve crystals to be stably attached to the surface of substrates through various chemical bonds, particularly ionic present invention ensures the synthesis of substrate-molecular sieve composites with enhanced attachment rate, degree of lateral close packing (DCP) and attachment strength in more time-saving and energy-saving manners. The present method works well for molecular sieve crystals with lager sizes (e.g., more than 3 μm) with no generation of parasitic crystals. Furthermore, the present invention shows excellent applicability to large substrates, enabling the mass production of substrate-molecular sieve composites.

专利号:US-11225655-B2
优先权日:2010-04-16
标题:Bi-functional complexes and methods for making and using such complexes
发明人：GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK
权利人:GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK; NUEVOLUTION AS
摘要:The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.

专利号:US-2003082830-A1
优先权日:1996-10-16
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products

专利号:US-9994558-B2
优先权日:2013-09-20
标题 :Multicyclic compounds and methods of using same
发明人：BALOGLU ERKAN; SHACHAM SHARON; SENAPEDIS WILLIAM; MCCAULEY DILARA; LANDESMAN YOSEF; GOLAN GALI; KALID ORI; SHECHTER SHARON
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to compounds represented by Structural Formula I: or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders (e.g., PAK-mediated, for example, PAK4-mediated, diseases and disorders).

专利号:US-7320993-B1
优先权日:1997-12-17
标题 :Aryl-substituted pyridylalkane, alkene, and alkine carboxamides useful as cytostatic useful as cytostatic and immuosuppressive agents
发明人：BIEDERMANN ELFI; HASMANN MAX; LOESER ROLAND; RATTEL BENNO; REITER FRIEDEMANN; SCHEIN BARBARA; SEIBEL KLAUS; VOGT KLAUS; WOSIKOWSKI KATJA; SCHEMAINDA ISABEL
权利人:ASTELLAS DEUTSCHLAND GMBH
摘要:The invention relates to new pyridylalkane, alkene, and alkine acid amides substituted with an aryl and/or heteroaryl residue according to the general formula (I), with a saturated or one or several-fold unsaturated hydrocarbon residue in the carboxylic acid group, methods for the synthesis of these compounds, medicaments containing these and their production as well as their therapeutic use, especially as cytostatic agents and immunosuppressive agents, for example in the treatment or prevention of various types of tumors and control of immune reactions such as autoimmune diseases.