CAS: 110-87-2; 3,4-Dihydro-2H-Pyran

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31518-13-5 26274-19-1 13039-50-4

上下游产品

CAS号97-99-4 四氢糠醇 | CAS号93-58-3 苯甲酸甲酯 | CAS号78-79-5 异戊二烯 | CAS号103-75-3 2-乙氧基-3,4-二氢吡喃 | CAS号109-87-5 甲缩醛 | CAS号571-57-3 4-溴萘酚 | CAS号625-23-0 2-甲基-2-己醇 | CAS号94800-75-6 2-(2,4,6-trimet... | CAS号108-95-2 苯酚 | CAS号110-62-3 正戊醛 | CAS号111841-07-7 1-[2-Hydroxy-4-... | CAS号110171-23-8 (3R)-3-甲基-4-[(四... | CAS号109403-64-7 N-(2-Furanylmet... | CAS号104802-31-5 3-hexyl-4-[2-(o... | CAS号110811-34-2 四氢-2H-吡喃-2-甲酸乙酯 | CAS号109430-31-1 (3R)-3-(oxan-2-... | CAS号111741-88-9 2-[4-(1,3-dithi... | CAS号1011-61-6 1,5-Pentanediol... | CAS号1051940-71-6 3-溴四氢-2H-吡喃-2-甲腈 | CAS号105966-45-8 2-(4-phenylmeth...

四氢糠醇置于alumina体系中,375.0 °C,101.33 Kpa 条件下,反应 12.0H,反应生成3,4-二氢-2H-吡喃
参考文献:Production Of 1,5-Pentanediol Via Upgrading Of Tetrahydrofufuryl Alcohol
标题:Production Of 1,5-Pentanediol Via Upgrading Of Tetrahydrofufuryl Alcohol
摘要:一种从四氢呋喃醇制备1,5-戊二醇的方法.该方法包括以下步骤:将四氢呋喃醇(thfa)脱水成二氢吡喃(dhp);在无均相酸的情况下,使至少部分dhp水化成2-羟基四氢吡喃(2-Hy-Thp);并对至少部分2-Hy-Thp进行氢化以制得1,5-戊二醇.该方法可以完全在无贵金属催化剂的情况下进行.

专利信息

专利号:WO-2023233371-A1
优先权日:2022-06-03
标 题:A continuous flow process for synthesis of organic azides
发明人：GNANAPRAKASAM BOOPATHY; PANDEY AKANKSHA M; MONDAL SHANKHAJIT
权利人:INDIAN INSTITUTE OF SCIENCE EDUCATION AND RES PUNE IISER PUNE
摘要:The present disclosure relates generally to the field of synthetic organic chemistry. More specifically, the disclosure is directed to a continuous flow process for synthesis of azides from alcohols and peroxides, wherein the process comprises azidation with trimethylsilyl azide and a catalyst Amberlyst-15. It is a non-hazardous, mild and controlled reaction giving good yields of azides. The azides can be further employed for synthesis of medicinally and industrially useful chemicals.

专利号:US-11161827-B2
优先权日:2019-04-05
标 题 :Catalytic systems for stereoselective synthesis of chiral amines by enantiodivergent radical C—H amination
发明人：Zhang xiao-xiang; Lang kai
权利人:TRUSTEES BOSTON COLLEGE; THE TRUSTEES OF BOSTON COLLEGE
摘要:In one aspect, the disclosure relates to a mode of asymmetric induction in radical processes based on sequential combination of enantiodifferentiative H-atom abstraction and stereoretentive radical substitution. Also disclosed is an asymmetric system for stereoselective synthesis of strained 5-membered cyclic sulfamides via radical 1,5-C—H amination of sulfamoyl azides. The disclosed metalloradical system can control the degree and sense of asymmetric induction in the catalytic radical C—H amination in a systematic manner. The disclosed system is applicable to a broad scope of substrates with different types of C(sp 3 )—H bonds and exhibits reactivity and selectivity, providing access to both enantiomers of useful 5-membered cyclic sulfamides in a highly enantioenriched form. Also disclosed are catalysts useful in these processes. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

专利号:WO-2013138200-A1
优先权日:2012-03-13
标 题 :Green chemistry synthesis of the malaria drug amodiaquine and analogs thereof
发明人：FORTUNAK JOSEPH MARIAN; KULKARNI AMOL ANANT; KING CHRISTOPHER
权利人:UNIV HOWARD
摘要:Methods are provided for a green chemistry one-pot synthesis of amodiaquine and amodiaquine analogs. The methods have a lower environmental impact, lower investment cost, reduced amounts of byproducts and impurities, and a shorter synthesis time, compared to current conventional synthesis methods. The methods reduce the total number of steps in the synthesis from four to five down to two, thereby simplifying production; and allow a reduced number of solvents and reagents to be used in production, thereby reducing the waste generated in the synthesis. The methods can reduce the waste to about 3-5 kilograms of waste generated per kilogram of product produced; and surprisingly improve the overall yield from 60-65% to greater than 90% as compared to the current conventional synthesis methods for amodiaquine and its analogs.

专利号:US-9388131-B2
优先权日:2011-04-27
标题:Automated synthesis of small molecules using chiral, non-racemic boronates
发明人：BURKE MARTIN D; LI JUNQI; GILLIS ERIC P
权利人:UNIV ILLINOIS
摘要:Provided are methods for making and using chiral, non-racemic protected organoboronic acids, including pinene-derived iminodiacetic acid (PIDA) boronates, to direct and enable stereoselective synthesis of organic molecules. Also provided are methods for purifying PIDA boronates from solution. Also provided are methods for deprotection of boronic acids from their PIDA ligands. The purification and deprotection methods may be used in conjunction with methods for coupling or otherwise reacting boronic acids. Iterative cycles of deprotection, coupling, and purification can be performed to synthesize chiral, non-racemic compounds. The methods are suitable for use in an automated chemical synthesis process. Also provided is an automated small molecule synthesizer apparatus for performing automated stereoselective synthesis of chiral, non-racemic small molecules using iterative cycles of deprotection, coupling, and purification.

专利号:WO-2019170521-A1
优先权日:2018-03-07
标题 :Synthesis of obeticholic acid and synthesis intermediate
发明人：BERNABEU MARTÃ?NEZ MARÃ?A DEL CARMEN; JIMÉNEZ ALONSO OSCAR; DOBARRO RODRÃ?GUEZ ALICIA; GABOARDI MAURO; CASTALDI GRAZIANO
权利人:MOEHS IBERICA SL
摘要:The present invention relates to a new intermediate for the synthesis of obeticholic acid, the compound of formula (I) or a geometric isomer thereof, a process for obtaining the same, as well as the use of said intermediate in the synthesis of obeticholic acid.

专利号:US-4351767-A
优先权日:1981-06-29
标题 :Synthesis of 24,25-dihydroxycholesterol
发明人：KAISER EMIL T
权利人:KAISER EMIL T
摘要:This invention relates to the synthesis of steroids which are useful for their biological activity or which may be converted to steroids which have such activity. More particularly, the invention pertains to the synthesis of 24,25-dihydroxycholesterol. It includes intermediate sterols of this synthesis and processes for their preparation.