CAS: 100324-81-0; (R)-1-(5-Hydroxyhexyl)-3,7-Dimethyl-1H-Purine-2,6(3H,7H)-Dione

上下游产品

利索茶碱 1-(5-Hydroxyhexyl)Theobromine 100324-81-0
己酮可可碱 Pentoxyphylline 06/05/6493
6-(3,7-Dimethyl-2,6-Dioxo-2,3,6,7-Tetrahydro-1H-Purin-1-yl)Hexan-2-Yl Acetate
可可碱 Theobromine / 83-67-0

📜可可碱置于甲醇,Sodium Tetrahydroborate,Potassium Carbonate体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应 20.0H,反应生成利索茶碱
参考文献:Compositions And Methods For The Treatment Of Chronic Diseases And Inflammatory Disorders
标题:Compositions And Methods For The Treatment Of Chronic Diseases And Inflammatory Disorders
摘要:本发明涉及公式i化合物或其药学可接受的盐,以及其多晶形,溶剂化物,对映体,立体异构体和水合物.含有公式i化合物的有效量的药物组合物,以及用于慢性疾病和炎症性疾病的治疗方法可以制成口服,颊粘膜,直肠,局部,经皮,经粘膜,静脉,肌肉注射,糖浆或注射剂的形式.这些组合物可以用于间歇性跛行,肢体阻塞动脉,血管性痴呆,佩罗尼氏病,神经病理损伤,镰状细胞贫血,高山病(高原反应)引起的恶心和头痛,急性酒精性和非酒精性脂肪性肝炎,酒精性肝病,放射治疗引起的纤维化病变,细胞因子释放综合征,子宫内膜异位症,静脉疾病,炎症,癌症,中风,血栓形成,败血症,坏疽,感染,1型糖尿病,2型糖尿病,胰岛β细胞退化,β细胞功能障碍,呼吸系统疾病,类风湿性关节炎,关节炎,骨关节炎和血管疾病的治疗.

专利信息

专利号:US-6306179-B1
优先权日:1997-10-22
标题:Method for the synthesis of 2-hydroxyalkyl-para-phenylenediamines, new 2-hydroxyalkyl-para-phenylenediamines, their use for oxidation dyeing, dyeing compositions and methods of dyeing
发明人：GENET ALAIN; LAGRANGE ALAIN
权利人:OREAL
摘要:The present invention relates to a new method for the synthesis of 2-hydroxyalkyl-para-phenylenediamines which are substituted or unsubstituted at the 5-position of the benzene ring, new 2-hydroxyalkyl-para-phenylenediamines which are substituted or unsubstituted at the 5-position of the benzene ring, their use for the oxidation dyeing of keratinous fibers, the dyeing compositions containing them, as well as the methods of dyeing using them.

专利号:WO-2021224477-A1
优先权日:2020-05-08
标 题 :A method for on-surface synthesis of a hexagonal boron nitride monolayer
发明人：CUN HUANYAO; HEMMI ADRIAN; MIAO ZICHUN; ALTMANN MICHAEL SCOTT; OSTERWALDER JÃœRG; GREBER THOMAS
权利人:UNIV ZUERICH; HONG KONG UNIV OF SCIENCE AND TECHNOLOGY
摘要:A method for the formation of a layer of boron nitride, especially a hexagonal boron nitride monolayer, on a substrate (300) wherein the method is characterized by the following steps: A) Providing a layer of boron nitride, especially a hexagonal boron nitride monolayer (200), on a first substrate (100); B) Delamination of the boron nitride layer (200) from the first substrate (100) and transfer of said layer (200) to a second substrate (300); C) Annealing the layer (200) on said second substrate (300) by heating to a first target temperature under formation of a first crystal structure, preferably in vacuum; D) Annealing the layer (200) on said second substrate (300) by heating to a second target temperature under formation of second crystal structure, wherein the second target temperature is higher than the first target temperature.

专利号:US-7141238-B2
优先权日:1998-04-02
标题:Compositions for reducing UV-induced inhibition of collagen biosynthesis in human skin
发明人：FISHER GARY J; VOORHEES JOHN J
权利人:UNIV MICHIGAN
摘要:Exposure of human skin to ultraviolet (UV) radiation from the sun not only induces the production of enzymes (matrix metalloproteinases) that degrade collagen, but also inhibits the synthesis of new collagen by inhibiting the synthesis of procollagen. This UV-induced inhibition of the synthesis of collagen can be prevented by the topical application of a retinoid or c-JUN inhibitor to the skin prior to exposure to UV radiation.

专利号:WO-9108220-A1
优先权日:1989-12-01
标 题:A method for the stepwise, controlled synthesis of chemical species, particularly peptides, coupled products obtained by the method and the use of these coupled products, e.g. as vaccines
发明人：HOUEN GUNNAR; HOLM ARNE
权利人:HOUEN GUNNAR; HOLM ARNE
摘要:Chemical species, particularly peptides, are synthesized by a stepwise, controlled process, in which a proteinaceous substance such as a protein is used as the synthesis substrate. The products obtained by the process can be used e.g. as vaccines against various diseases and as matrix materials or carrier molecules.

专利号:US-10676422-B2
优先权日:2014-11-28
标题:Kinetic resolution of racemic hydroxy ester via asymmetric catalytic hydrogenation and application thereof
发明人：ZHOU QILIN; XIE JIANHUA; YANG XIAOHUI; WANG LIXIN
权利人:ZHEJIANG JIUZHOU PHARM CO LTD
摘要:The present invention relates to kinetic resolution of racemic δ-hydroxyl ester via asymmetric catalytic hydrogenation and an application thereof. In the presence of chiral spiro pyridyl phosphine ligand Iridium catalyst and base, racemic δ-hydroxyl esters were subjected to asymmetric catalytic hydrogenation to obtain extent optical purity chiral δ-hydroxyl esters and corresponding 1,5-diols. An optically active chiral δ-hydroxyl ester and 1,5-diols can be obtained at very high enantioselectivity and yield with relatively low usage of catalyst. The chiral δ-hydroxyl ester and 1,5-diols obtained by using the method can be used as a critical raw material for asymmetric synthesis of chiral drugs (R)-lisofylline and natural drugs (+)-civet, (−)-indolizidine 167B and (−)-coniine.

专利号:US-5629423-A
优先权日:1994-05-16
标题:Asymmetric synthesis of chiral secondary alcohols
发明人：KLEIN J PETER; LEIGH ALISTAIR J; MICHNICK JOHN; KUMAR ANIL M; UNDERINER GAIL E
权利人:CELL THERAPEUTICS INC
摘要:A process for synthesizing enantiomerically pure chiral secondary alcohol compounds linked to a heterocyclic core moiety, using a natural chiral molecule starting material. The inventive process is particularly useful for bulk manufacturing of chiral secondary alcohol compounds.