专利号:US-2012282652-A1 优先权日:2011-02-28 标题 :Preparation of peptide mixtures by protease catalysis designed to provide useful biological and physical properties 发明人:GROSS RICHARD A; VISWANATHAN KODANDARAMAN; QIN XU 权利人:GROSS RICHARD A; VISWANATHAN KODANDARAMAN; QIN XU; POLITECHNIC INST UNIV NEW YORK 摘要:A process for preparing unique peptide mixtures with a broad range of uses using combinations of natural and non-natural amino acid alkyl ester monomers and specific combinations of these monomers as dimers, trimers and higher oligomers selected from the large group of structural motifs that lead to useful physical and/or biological properties and that have been or may be identified from solid state peptide synthesis, isolation of peptides from natural sources, and production of peptides by recombinant DNA methods, or identification of peptides by recombinant methods such as phage display, the method of peptide synthesis comprising a) admixing one or more natural and non-natural amino acid alkyl ester monomer, dimer, trimer and higher oligomers with one or more proteases in a reaction medium; b) heating the mixture to between about 5° C. to about 90° C. for between 5 minutes and 24 hours; and c) recovering the formed oligopeptide.
专利号:WO-2024108286-A1 优先权日:2022-11-23 标 题 :Cosmetic composition for inducing melanin synthesis in an individual or animal; production process; cosmetic method and use 发明人:VIDAL MAGALHÃES WAGNER; BUENO DE CAMARGO JUNIOR FLÃ?VIO; ROBERTO ROSSAN MARCOS; THOMAZ CAMILO ANDREW 权利人:CHEMYUNION LTDA 摘要:The present invention describes a novel composition for inducing melanin synthesis in an individual or animal, as well as the use thereof to prevent and/or reverse the process of greying of the hair.
专利号:US-7544375-B1 优先权日:2006-06-12 标 题:Composition 发明人:BELLIN HOWARD T; DE BORG BEATRICE 权利人:SWISS SKIN REPAIR INC 摘要:A topically applied composition or cream for treatment of the skin. A preferred composition includes a) a skin plumper; b) a tetrapeptide; c) a soya plant extract; d) Centella Asiatica extract; e) a cosmetic soothing or anti-inflammatory component; f) a component that acts on fibronectin synthesis; g) a moisturizing component; h) a structured conditioning component; i) an emulsifier component; and j) a transdermal delivery agent.
1: Mondon P, Hillion M, Peschard O, Andre N, Marchand T, Doridot E, Feuilloley MG, Pionneau C, Chardonnet S. Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications. J Cosmet Dermatol. 2015 Jun;14(2):152-60. doi: 10.1111/jocd.12135. Epub 2015 Mar 27.
合成参考文献
参考文献:10.1111/ics.12494 摘要:Almeida Scalvino S, Chapelle A, Hajem N, Lati E, Gasser P, Choulot J, Michel L, Hocquaux M, Loing E, Attia J, Wdzieczak‐Bakala J. Efficacy of an agonist of α‐MSH, the palmitoyl tetrapeptide‐20, in hair pigmentation. Intern J of Cosmetic Sci. 2018 Oct;40(5):516–24. doi: 10.1111/ics.12494.