CAS: 9015-71-8; Thr-Lys-Pro-Arg

该化合物是一种生物活性peptide,由41种氨基酸组成,主要用于低脑-肾上腺(HPA)轴管,这种合成或纯化的卵巢通用报告格式形式因其在刺激脑下垂体激素释放肾上皮质激素(ACTH)方面的高度特殊性和效力,在...

英文名称Thr-Lys-Pro-Arg
中文名称CRF1受体激动剂
其它别名Sqeppisldltfhllrevlemtkadqlaqqahsnrklldia-Nh2; Ser-Gln-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Thr-Lys-Ala-Asp-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Leu-Asp-Ile-Ala-Nh2; Ser-Gln-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Thr-Lys-Ala-Asp-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Leu-Asp-Ile-Ala-Nh2 Ovine; Corticotropin-Releasinghormone; Corticotropin-Releasinghormone))-; Corticotropin Releasing Factor Sheep, ≥ (Hplc); Corticotropin Releasing Factor Sheep; Corticotropin Releasing Factor, Ovine
CAS编号9015-71-8
MFCD编号:MFCD00286536
分子式:C205H339N59O63S1分子量:4670.31
产品CID: 1933378
产品分类生物 → 生物化学试剂 → 抑制剂激活剂

相似结构搜索
产品信息参考;;;
InChIKey: IESDGNYHXIOKRW-YXMSTPNBSA-N
1S/C21H40N8O6/c1-12(30)16(23)18(32)27-13(6-2-3-9-22)19(33)29-11-5-8-15(29)17(31)28-14(20(34)35)7-4-10-26-21(24)25/h12-16,30H,2-11,22-23H2,1H3,(H,27,32)(H,28,31)(H,34,35)(
计算化学: 氢键受体数9.0氢键供体数8.0可旋转键数15.0

MSDS等安全信息

警示词warning
危险描述H303 May be harmful if swallowed+H313 Skin contact may be harmful+H333 Inhalation may be harmful to the body
防范说明P264Thoroughly clean after treatmentP280Wear protective gloves/Wear protective clothing/Wear protective goggles/Wear a protective maskP305If it enters the eyesP351Rinse carefully with water for a few minutesP338Remove the contact lens(If any)And easy to operate,Continue flushingP337If eye irritation persistsP313Obtain medical advice/care
安全声明H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
WGK Germany3

上下游产品

N-Benzyloxycarbonyl-L-Prolyl-L-Arginine 60889-67-0

合成工艺路线路线简述

📜H-Lys(2Cl,Z)-Pro-Arg(Tos)-Obn置于1-羟基苯并三唑甲基乙基硫醚,茴香硫醚,苯甲醚,N,N'-二环己基碳二亚胺体系中,用 N,N-二甲基甲酰胺,三氟乙酸作为反应溶剂,化学反应 1.0H,反应生成 Crf1受体激动剂
参考文献:硫酰化剂.硫代苯并咪唑酮衍生物在制备硫tuftftsin类似物中的用途.
标题:硫酰化剂.硫代苯并咪唑酮衍生物在制备硫tuftftsin类似物中的用途.
摘要:描述了硫酰化试剂1的性质和特征反应.这些试剂能够在序列的特定位点将硫酰胺键引入正在生长的肽中.这种方法学的普遍性和效率通过塔夫辛的三种单硫代类似物的合成得到证明.
DOI:10.1016/s0040-4020(01)81544-1