专利号:US-5945548-A 优先权日:1995-03-03 标题:Process for the synthesis of α-substituted acrylic acids and their application 发明人:DUHAMEL PIERRE; DUHAMEL LUCETTE; DANVY DENIS; MONTEIL THIERRY; LECOMTE JEANNE-MARIE; SCHWARTZ JEAN-CHARLES 权利人:BIOPROJECT SOC CIV 摘要:Process for the synthesis of α-substituted acrylic acids of general formula (I) and their application to the synthesis of N-(mercaptoacyl)aminoacid derivatives of formula (II). ##STR1##
专利号:US-4627968-A 优先权日:1984-09-10 标 题 :Synthesis of crystalline aluminosilicate with alkylurea or alkylthiourea 发明人:KAI TADASHI 权利人:ASAHI CHEMICAL IND 摘要:In the synthesis of a crystalline aluminosilicate by heating an aqueous mixture containing a silica source, an alumina source and an alkali metal source, at least one compound selected from lower alkylureas and lower alkylthioureas is permitted to co-exist with the mixture.
专利号:WO-2014011120-A1 优先权日:2012-07-13 标 题 :Endoperoxides, synthesis and uses thereof for the treatment of neoplastic diseases such as cancer 发明人:TAN NGUAN SOON; CHIBA SHUNSUKE 权利人:UNIV NANYANG TECH 摘要:The present invention generally relates to processes and methods for the synthesis of endoperoxide compounds. More specifically, the invention relates to a method for preparing endoperoxide compounds starting from an aryl imine of formula (I) in the presence of a metallic catalyst and oxygen. The present invention also relates to endoperoxide compounds of formula (III) and their pharmaceutically acceptable salts thereof, useful for therapy. All substituents are defined herein. Also disclosed are methods of treating cancer using the compounds of formula (III).
专利号:US-6051704-A 优先权日:1996-07-22 标题:Synthesis of macrocyclic tetraamido-N ligands 发明人:GORDON-WYLIE SCOTT W; COLLINS TERRENCE J 权利人:UNIV CARNEGIE MELLON 摘要:New synthetic methods for the preparation of macrocyclic amido-N donor ligands are provided. The primary method of the present invention involves in general only two synthetic steps. In the first step, an α or β amino carboxylic acid is allowed to react with an optimal (approximately stoichiometric) amount of an activated malonate or oxalate derivative with mild heating. Upon completion of the double coupling reaction, hydrolysis of the reaction mixture yields a diamide containing intermediate (a macro linker). In the second step, stoichiometric amounts of a diamine, preferably an orthophenylene diamine, are added to the macro linker intermediate in the presence of a coupling agent and heat. This second double coupling reaction, is allowed to proceed for a period of time sufficient to produce a macrocyclic tetraamido compound. The substituent groups on the α or β amino carboxylic acid, the malonate, and the aryl diamine may all be selectively varied so that the resulting tetraamido macrocycle can be tailored to specific desired end uses. The macrocyclic tetraamide ligand may then be complexed with a metal, such as a transition metal, and preferably the middle and later transition metals, to form a robust chelate complex suitable for catalyzing oxidation reactions.
专利号:US-8193180-B2 优先权日:2007-01-24 标 题 :N-amino tetrahydrothiazine derivatives, method of manufacture and use 发明人:BRARD LAURENT; SINGH RAKESH KUMAR; KIM KYU KWANG; SAULNIER-SHOLLER GISELLE 权利人:BRARD LAURENT; SINGH RAKESH KUMAR; KIM KYU KWANG; SAULNIER-SHOLLER GISELLE; WOMEN & INFANTS HOSPITAL 摘要:This invention comprises the innovative synthesis of N-amino tetrahydrothiazine free bases and their salts. This invention further comprises the use of the derivatives and their therapeutic application as anticancer agents. Further this invention comprises their manufacture and use.
专利号:US-11702347-B2 优先权日:2019-11-12 标 题:Synthesis of mixed metal chalcogenides using solid phase method 发明人:ENHESSARI MORTEZA; SALEHABADI ALI; KHOOBI ASMA 权利人:ENHESSARI MORTEZA; SALEHABADI ALI; KHOOBI ASMA; NARAGH BRANCH ISLAMIC AZAD UNIV 摘要:An exemplary method for producing a mixed metal chalcogenide under atmospheric pressure may include forming a reaction mixture by mixing a first metal chalcogenide and a second metal chalcogenide. An exemplary method may further include pouring a first layer of NaCl within a reactor, where an exemplary reactor may include a container and a cap. Pouring an exemplary first layer of NaCl within an exemplary reactor may include pouring an exemplary first layer of NaCl on an exemplary base end of an exemplary container of the exemplary reactor. An exemplary method may further include pouring an exemplary reaction mixture into an exemplary container on top of an exemplary first layer of NaCl, pouring a second layer of NaCl into an exemplary container on top of an exemplary reaction mixture, sealing an exemplary container by closing an exemplary cap and pouring molten NaCl on top of the exemplary cap, and heating an exemplary reactor at a predetermined temperature for a predetermined time.
参考标题:Evaluation Of Pnu-159682 Antibody Drug Conjugates (Adcs) 作者:Dane Holte,Joseph P. Lyssikatos,Amanda M. Valdiosera,Zachary Swinney,Vikram Sisodiya,Joseph Sandoval,Christina Lee,Monette A. Aujay,Robert B. Tchelepi,Omar M. Hamdy,Christine Gu,Baiwei Lin,Hetal Sarvaiya,Marybeth A. Pysz,Amy Laysang,Samuel Williams,Dong Jun Lee,Magda K. Holda,James W. Purcell,Julia Gavrilyuk |发布日期:2020.12 摘要:Interesting Starting Point For The Development Of A New Suite Of Linker Drugs For Antibody Drug Conjugates (Adcs). Structure Activity Relationships Were Explored On The Small Molecule Which Led To Six Linker Drugs Being Developed For Conjugation To Antibodies. Herein We Describe The Synthesis Of Novel Pnu-159682 Derivatives And The Subsequent Linker Drugs As Well As The Corresponding Biological Evaluations
合成参考文献
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