CAS: 6972-05-0; 1,1-Dimethylthiourea

该化合物是一种硫尿素衍生物,含有分子式C3H8N2S.在化学和生化应用中,它通常被用作选择性消毒剂和致癌剂.DMTU具有很强的抗氧化特性,有效中和反应氧物种,如氢氧化基和超氧化基,使其在氧化应激反应研究中具有价值.在生理条件下,它的稳定可以可靠地用于生物研究.此外,DMTU是有机合成的多种中间体,特别是在生产三环化合物方面.该化合物的高度纯度和一贯性使得它成为需要精确的激进抑制或减少的实验室和工业应用的首选.

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2782-91-4 6926-58-5 598-52-7

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合成工艺路线路线简述

    📜4,4-Dimethyl-3-Thio-Allophanic Acid Ethyl Ester置于盐酸体系中,化学反应生成 N,N-二甲基硫脲
    参考文献:Hartmann,H.; Reuther,I.,Journal Fur Praktische Chemie (Leipzig 1954),1973,Vol. 315,P. 144-148
    标题:Hartmann,H.; Reuther,I.,Journal Fur Praktische Chemie (Leipzig 1954),1973,Vol. 315,P. 144-148

    海关参考信息

    专利信息


    专利号:US-5945548-A
    优先权日:1995-03-03
    标题:Process for the synthesis of α-substituted acrylic acids and their application
    发明人:DUHAMEL PIERRE; DUHAMEL LUCETTE; DANVY DENIS; MONTEIL THIERRY; LECOMTE JEANNE-MARIE; SCHWARTZ JEAN-CHARLES
    权利人:BIOPROJECT SOC CIV
    摘要:Process for the synthesis of α-substituted acrylic acids of general formula (I) and their application to the synthesis of N-(mercaptoacyl)aminoacid derivatives of formula (II). ##STR1##

    专利号:US-4627968-A
    优先权日:1984-09-10
    标 题 :Synthesis of crystalline aluminosilicate with alkylurea or alkylthiourea
    发明人:KAI TADASHI
    权利人:ASAHI CHEMICAL IND
    摘要:In the synthesis of a crystalline aluminosilicate by heating an aqueous mixture containing a silica source, an alumina source and an alkali metal source, at least one compound selected from lower alkylureas and lower alkylthioureas is permitted to co-exist with the mixture.

    专利号:WO-2014011120-A1
    优先权日:2012-07-13
    标 题 :Endoperoxides, synthesis and uses thereof for the treatment of neoplastic diseases such as cancer
    发明人:TAN NGUAN SOON; CHIBA SHUNSUKE
    权利人:UNIV NANYANG TECH
    摘要:The present invention generally relates to processes and methods for the synthesis of endoperoxide compounds. More specifically, the invention relates to a method for preparing endoperoxide compounds starting from an aryl imine of formula (I) in the presence of a metallic catalyst and oxygen. The present invention also relates to endoperoxide compounds of formula (III) and their pharmaceutically acceptable salts thereof, useful for therapy. All substituents are defined herein. Also disclosed are methods of treating cancer using the compounds of formula (III).

    专利号:US-6051704-A
    优先权日:1996-07-22
    标题:Synthesis of macrocyclic tetraamido-N ligands
    发明人:GORDON-WYLIE SCOTT W; COLLINS TERRENCE J
    权利人:UNIV CARNEGIE MELLON
    摘要:New synthetic methods for the preparation of macrocyclic amido-N donor ligands are provided. The primary method of the present invention involves in general only two synthetic steps. In the first step, an α or β amino carboxylic acid is allowed to react with an optimal (approximately stoichiometric) amount of an activated malonate or oxalate derivative with mild heating. Upon completion of the double coupling reaction, hydrolysis of the reaction mixture yields a diamide containing intermediate (a macro linker). In the second step, stoichiometric amounts of a diamine, preferably an orthophenylene diamine, are added to the macro linker intermediate in the presence of a coupling agent and heat. This second double coupling reaction, is allowed to proceed for a period of time sufficient to produce a macrocyclic tetraamido compound. The substituent groups on the α or β amino carboxylic acid, the malonate, and the aryl diamine may all be selectively varied so that the resulting tetraamido macrocycle can be tailored to specific desired end uses. The macrocyclic tetraamide ligand may then be complexed with a metal, such as a transition metal, and preferably the middle and later transition metals, to form a robust chelate complex suitable for catalyzing oxidation reactions.

    专利号:US-8193180-B2
    优先权日:2007-01-24
    标 题 :N-amino tetrahydrothiazine derivatives, method of manufacture and use
    发明人:BRARD LAURENT; SINGH RAKESH KUMAR; KIM KYU KWANG; SAULNIER-SHOLLER GISELLE
    权利人:BRARD LAURENT; SINGH RAKESH KUMAR; KIM KYU KWANG; SAULNIER-SHOLLER GISELLE; WOMEN & INFANTS HOSPITAL
    摘要:This invention comprises the innovative synthesis of N-amino tetrahydrothiazine free bases and their salts. This invention further comprises the use of the derivatives and their therapeutic application as anticancer agents. Further this invention comprises their manufacture and use.

    专利号:US-11702347-B2
    优先权日:2019-11-12
    标 题:Synthesis of mixed metal chalcogenides using solid phase method
    发明人:ENHESSARI MORTEZA; SALEHABADI ALI; KHOOBI ASMA
    权利人:ENHESSARI MORTEZA; SALEHABADI ALI; KHOOBI ASMA; NARAGH BRANCH ISLAMIC AZAD UNIV
    摘要:An exemplary method for producing a mixed metal chalcogenide under atmospheric pressure may include forming a reaction mixture by mixing a first metal chalcogenide and a second metal chalcogenide. An exemplary method may further include pouring a first layer of NaCl within a reactor, where an exemplary reactor may include a container and a cap. Pouring an exemplary first layer of NaCl within an exemplary reactor may include pouring an exemplary first layer of NaCl on an exemplary base end of an exemplary container of the exemplary reactor. An exemplary method may further include pouring an exemplary reaction mixture into an exemplary container on top of an exemplary first layer of NaCl, pouring a second layer of NaCl into an exemplary container on top of an exemplary reaction mixture, sealing an exemplary container by closing an exemplary cap and pouring molten NaCl on top of the exemplary cap, and heating an exemplary reactor at a predetermined temperature for a predetermined time.

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    主要参考文献

    参考标题:Evaluation Of Pnu-159682 Antibody Drug Conjugates (Adcs)
    作者:Dane Holte,Joseph P. Lyssikatos,Amanda M. Valdiosera,Zachary Swinney,Vikram Sisodiya,Joseph Sandoval,Christina Lee,Monette A. Aujay,Robert B. Tchelepi,Omar M. Hamdy,Christine Gu,Baiwei Lin,Hetal Sarvaiya,Marybeth A. Pysz,Amy Laysang,Samuel Williams,Dong Jun Lee,Magda K. Holda,James W. Purcell,Julia Gavrilyuk |发布日期:2020.12
    摘要:Interesting Starting Point For The Development Of A New Suite Of Linker Drugs For Antibody Drug Conjugates (Adcs). Structure Activity Relationships Were Explored On The Small Molecule Which Led To Six Linker Drugs Being Developed For Conjugation To Antibodies. Herein We Describe The Synthesis Of Novel Pnu-159682 Derivatives And The Subsequent Linker Drugs As Well As The Corresponding Biological Evaluations

    合成参考文献


    参考文献:10.1104/pp.111.173153
    摘要:Tisi A, Federico R, Moreno S, Lucretti S, Moschou PN, Roubelakis-Angelakis KA, Angelini R, Cona A. Perturbation of polyamine catabolism can strongly affect root development and xylem differentiation. Plant Physiol. 2011 Sep;157(1):200–15.
    参考文献:10.1007/s00595-010-4394-x
    摘要:Teke Z, Adali F, Kelten EC, Enli Y, Sackan KG, Karaman K, Akbulut M, Goksin I. Mannitol attenuates acute lung injury induced by infrarenal aortic occlusion-reperfusion in rats. Surg Today. 2011 Jul;41(7):955–65. doi: 10.1007/s00595-010-4394-x.
    参考文献:10.1186/1617-9625-9-8
    摘要:Yukihiro M, Hiramatsu T, Kawano T. Lethal impacts of cigarette smoke in cultured tobacco cells. Tobacco Induced Diseases. 2011 Jul 16;9(1):8. doi: 10.1186/1617-9625-9-8.
    参考文献:10.1371/journal.pone.0021926
    摘要:Randazzo J, Zhang Z, Hoff M, Kawada H, Sachs A, Yuan Y, Haider N, Kador P. Orally Active Multi-Functional Antioxidants Are Neuroprotective in a Rat Model of Light-Induced Retinal Damage. PLoS ONE. 2011 Jul 14;6(7):e21926. doi: 10.1371/journal.pone.0021926.
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