CAS: 638-07-3; Ethyl 4-Chloro-3-Oxobutanoate

相似化合物

86728-85-0 90866-33-4 13176-46-0

上下游产品

CAS号6082-74-2 4,4-dichloro-3-... | CAS号41295-64-1 4-chloro-3-oxob... | CAS号64-17-5 乙醇 | CAS号591-78-6 2-己酮 | CAS号100-52-7 苯甲醛 | CAS号106302-03-8 [3-(乙氧羰基)-2-氧丙基... | CAS号105435-14-1 diethyl 2-(chlo... | CAS号34265-58-2 5-甲基水杨酸乙酯 | CAS号40207-03-2 4-(4-甲氧苯基)-3-氨基硫脲 | CAS号787-07-5 丁二酰丁二酸二乙酯 | CAS号38220-75-6 1-(5-溴苯并呋喃-2-基)乙酮 | CAS号41051-21-2 °Ctyl 4-chloro-... | CAS号59128-02-8 乙基(6-氯咪唑并[1,2-a... | CAS号43071-52-9 2-乙酰基-7-甲氧基苯并呋喃

4,4-二氯-3-氧代丁酸乙酯置于五羰基铁,水体系中,用 苯 作为反应溶剂,以65%的收率获得产物4-氯乙酰乙酸乙酯
参考文献:Reactions Of Diethyl Dibromomalonate And Ethyl 2,2-Dichloroacetoacetate With Water And Carbonyl Compounds (Aldehydes And Ketones) In The Presence Of Pentacarbonyliron
标题:Reactions Of Diethyl Dibromomalonate And Ethyl 2,2-Dichloroacetoacetate With Water And Carbonyl Compounds (Aldehydes And Ketones) In The Presence Of Pentacarbonyliron
摘要:Diethyl Dibromomalonate And Ethyl 2,2-Dichloroacetoacetate Are Effectively Reduced With The System Pentacarbonyliron-Proton-Donor Compound (Water Or Butyl Methyl Ketone) To Give The Corresponding Hydrodehalogenation Products. These Results Provide A Support For The Previous Assumption That The Key Reaction Stage Is Reduction With Pentacarbonyliron Of Initially Formed Radical To Anion Which Is Then Involved In Proton Transfer.
DOI:10.1023/b:Rujo.0000045179.42952.58

专利信息

专利号:US-11078465-B2
优先权日:2018-02-12
标题:Alcohol dehydrogenase mutant and application thereof in synthesis of diaryl chiral alcohols
发明人：NI YE; WANG YUE; DAI WEI; XU GUOCHAO; ZHOU JIEYU
权利人:UNIV JIANGNAN
摘要:The present disclosure discloses an alcohol dehydrogenase mutant and application thereof in synthesis of diaryl chiral alcohols, and belongs to the technical field of bioengineering. The alcohol dehydrogenase mutant of the present disclosure has excellent catalytic activity and stereoselectivity, and may efficiently catalyze the preparation of a series of chiral diaryl alcohols in R- and S-configurations. By coupling alcohol dehydrogenase of the present disclosure to glucose dehydrogenase or formate dehydrogenase, the synthesis of chiral diaryl alcohol intermediates of various antihistamines may be achieved. Compared with the prior art, a method for preparing diaryl chiral alcohols through asymmetric catalytic reduction using the alcohol dehydrogenase of the present disclosure has the advantages of simple and convenient operation, high substrate concentration, complete reaction and high product purity, and has great industrial application prospects.

专利号:US-12281348-B2
优先权日:2020-11-08
标 题:Method for the continuous flow synthesis of (R)-4-halo-3-hydroxy-butyrate
发明人：CHEN FENER; CHENG DANG; HUANG ZEDU; LIU MINJIE; HUANG HUASHAN; JIANG MEIFEN; WANG LULU
权利人:UNIV FUDAN
摘要:This application relates to organic synthesis, and more particularly to a method for the continuous flow synthesis of (R)-4-halo-3-hydroxy-butyrate using a micro-reaction system. This application performs an enzymatic asymmetric reduction of a substrate solution containing halogenated acetoacetate and a biocatalyst solution in the micro-reaction system composed of a micro-mixer, a micro-channel reactor, and a pH regulator to obtain the (R)-4-halo-3-hydroxy-butyrate. Compared to the prior art, the reaction time of the method is only a few minutes, the yield of the product (R)-4-halo-3-hydroxy-butyrate is greater than 95%, the reaction process is continuous, the degree of automation is high, the efficiency is high, and the process is simple to operate and easy to be used in industrialized production.

专利号:US-11028057-B2
优先权日:2018-02-28
标题:Process for the synthesis of 6-chloromethyluracil
发明人：MORANA FABIO; GOBBATO STEFANO; ROLETTO JACOPO; PAISSONI PAOLO
权利人:PROCOS SPA
摘要:The invention relates to a process for the synthesis of 6-chloromethyluracil (6-(chloromethyl)pyrimidin-2,4(1H,3H)-dione) from ethyl 4-chloroacetoacetate and S-methylisothiourea hemisulfate via isolation of the novel intermediate 6-(chloromethyl)-6-hydroxy-2-(methylthio)-5,6-dihydropyrimidin-4(1H)-one, and its subsequent treatment with aqueous sulfuric acid. Formula (I).

专利号:US-7153960-B2
优先权日:2001-12-10
标 题:Synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones
发明人：ZHOU JIACHENG; OH LYNETTE M; MA PHILIP; LI HUI-YIN; CONFALONE PASQUALE
权利人:BRISTOL MYERS SQUIBB CO
摘要:A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones of the type shown below from appropriate phenyl hydrazines is described. n nThese compounds are useful as factor Xa inhibitors.

专利号:US-2008138866-A1
优先权日:2005-03-11
标题 :Process for the Preparation of (R)-4,4-Dialkoxy-Pyran-3-Ols Such as (R)-4,4-Dimethoxy-Pyran-3-Ol
发明人：MOORE JEFFREY C; KOSJEK BIRGIT; NTI-GYABAAH JOSEPH
权利人:MOORE JEFFREY C; KOSJEK BIRGIT; NTI-GYABAAH JOSEPH
摘要:The present invention is concerned with novel processes for the preparation of (R)-4,4-dimethoxy-pyran-3-ol. This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity including CCR2 antagonists.

专利号:US-4782162-A
优先权日:1984-05-17
标 题:Novel intermediates for the synthesis of cephalosporins
发明人：BOBERG MICHAEL; NAAB PAUL; SAMAAN SAMIR
权利人:BAYER AG
摘要:The new compounds of the formula ##STR1## in which Acyl is alkylcarbonyl optionally substituted by halogen or aryl, or arylcarbonyl, which is substituted by lower alkoxy, halogen or nitro, n R 1 is an alkyl or alkenyl radical, and n R 4 is an optionally substituted branched or straight-chain C 1 -C 6 -alkyl radical or a cycloalkyl radical, n are produced by reacting a 2-halogenoacetylacrylic acid ester of the formula ##STR2## with an acylthiourea of the formula ##STR3## The reaction can be conducted in aqueous DMF, substantially pure Z-isomer selectively crystallizing out.