CAS: 61363-56-2; 2H-Pyran-3,5(4H,6H)-Dione

该化合物是一种环形二氯酮化合物,其特点是六人组成的氧烷环,在3和5个位置上有碳基组.这一结构赋予适合有机合成应用的回活动性,特别是作为三环化合物的前体或作为制药和农用化学中间体的构件.它的对称二氯酮功能可以进行选择性转换,包括核生殖器添加或凝聚,使其对构建复杂的分子框架很有价值.该化合物在标准条件下的稳定性和与普通溶剂的兼容性进一步提高其在实验室和工业环境中的效用. Oxane-35-dione经常用于需要受控的环开关或功能化反应的研究.

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CAS号61363-66-4 (2-氧代丙氧基)-乙酸甲酯 | CAS号67500-49-6 methyl 2-(prop-... | CAS号10041-27-7 (2-甲基烯丙氧基)-乙酸 | CAS号137840-76-7 (2-甲基烯丙氧基)-乙酸甲酯

合成工艺路线路线简述

    📜(2-甲基烯丙氧基)-乙酸置于potassium Osmate(Vi),Sodium Periodate,Amberlyst-15 Ion-Exchange Resin,Sodium T-Butanolate体系中,用 四氢呋喃,水 作为反应溶剂,化学反应 20.08H,反应生成 2H-吡喃-3,5(4H,6H)-二酮
    参考文献:An Improved Synthesis Of Pyran-3,5-Dione: Application To The Synthesis Of Abt-598,A Potassium Channel Opener,Via Hantzsch Reaction
    标题:An Improved Synthesis Of Pyran-3,5-Dione: Application To The Synthesis Of Abt-598,A Potassium Channel Opener,Via Hantzsch Reaction
    摘要:Ketoester 1 Is Cyclized To Give Pyran-3,5-Dione 2 In 78% Yield Using A Parallel Addition Of Ketoester 1 And Base Naobu In Refluxing The Compared To The Previously Reported Procedures,These Optimized Conditions Have Significantly Increased The Yield Of This Transformation And The Quality Of Pyran 2 And Prove To Be Suitable For Large-Scale Preparation. An Application Of 2 To The Synthesis Of Abt-598,A Potassium Channel Opener,Is Demonstrated.
    DOI:10.1021/jo052226W

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    专利信息


    专利号:WO-2023002323-A1
    优先权日:2021-07-19
    标 题 :Synthesis of substituted tricyclic amides and analogues thereof

    专利号:US-2024327419-A1
    优先权日:2021-07-19
    标 题 :Synthesis of substituted tricyclic amides and analogues thereof
    发明人：MASON JEREMY; PALLERLA MAHESH; PAMULAPATI GANAPATI REDDY
    权利人:ARBUTUS BIOPHARMA CORP
    摘要:The present disclosure includes synthetic methods for preparing certain substituted tricyclic amides, which can be used to treat, ameliorate, and/or prevent hepatitis B virus (HBV) and/or hepatitis D virus (HDV) infections in a subject.

    专利号:CN-117730082-A
    优先权日:2021-07-19
    标 题:Synthesis of substituted tricyclic amides and analogs thereof

    专利号:KR-20240046184-A
    优先权日:2021-07-19
    标题 :Synthesis of substituted tricyclic amides and analogues thereof

    专利号:EP-4373823-A1
    优先权日:2021-07-19
    标题:Synthesis of substituted tricyclic amides and analogues thereof

    专利号:CA-3225801-A1
    优先权日:2021-07-19
    标 题:Synthesis of substituted tricyclic amides and analogues thereof

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    合成参考文献


    参考文献:10.1055/s-0036-1590909
    摘要:Vilarrasa J, Castro-Alvarez A, Carneros H, Costa AM. Computer-Aided Insight into the Relative Stability of Enamines. Synthesis. 2017 Oct 04;49(24):5285–306. doi: 10.1055/s-0036-1590909.
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