CAS: 5736-88-9; 4-Butoxybenzaldehyde

该化合物是一种合成芳香藻,其特点是苯环上存在一种但氧替代物,这种化合物通常用作有机合成的中间体,特别是在生产药品,香料和特殊化学品方面.它的丁氧混合物组增加了有机溶剂的溶解性,便利了各种合成途径的反应.藻类功能使它成为凝聚,氧化和减少反应的多用途前体.它具有一种固定的分子结构(C11H14O2),它具有一贯的再活性和纯度,适合需要精确化学转化的应用.建议在惰性条件下进行适当的处理和储存以保持稳定.

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欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号109-65-9 正溴丁烷 | CAS号123-08-0 4-羟基苯甲醛; 对羟基苯甲醛 | CAS号1122-91-4 对溴苯甲醛 | CAS号71-36-3 正丁醇 | CAS号862387-21-1 (4-buthoxypheny... | CAS号6214-45-5 4-丁氧基苯基甲醇 | CAS号542-69-8 碘代正丁烷 | CAS号874-80-6 N-丁基溴化吡啶 | CAS号123-11-5 4-甲氧基苯甲醛; 对甲氧基苯... | CAS号778-28-9 对甲苯磺酸正丁酯 | CAS号38746-93-9 4-丁氧基苯乙腈 | CAS号36405-17-1 4'-丁氧基苯亚甲基-4-氰基苯胺 | CAS号39777-05-4 p-丁氧基苄烯-p-戊基苯胺 | CAS号5203-14-5 4-正丁氧基苯甲腈 | CAS号4547-57-3 4-丁氧基苯乙酸 | CAS号29743-09-7 p-丁氧基苄烯-p-丁胺 | CAS号235108-64-2 5-(4-butoxyphen... | CAS号6214-45-5 4-丁氧基苯基甲醇 | CAS号3179-08-6 4-(2-硝基乙烯基)苯酚 | CAS号115514-08-4 2-(4'-butoxyphe...

合成工艺路线路线简述

    📜4-丁氧基苯甲醇置于乌洛托品,2-氯-1,3-二甲基氯化咪唑啉,三乙胺,溶剂黄146体系中,用 氯仿 作为反应溶剂,化学反应 7.0H,以47%的收率获得产物4-丁氧基苯甲醛
    参考文献:2-Chloro-1,3-Dimethylimidazolinium Chloride. 3. Utility For Chlorination,Oxidation,Reduction,And Rearrangement Reactions
    标题:2-Chloro-1,3-Dimethylimidazolinium Chloride. 3. Utility For Chlorination,Oxidation,Reduction,And Rearrangement Reactions
    摘要:2-Chloro-1,3-Dimethylimidazolinium Chloride (1),Which Can Act As A Powerful Dehydrating Equivalent To Dcc (2),Is Also Applicable To Chlorination,Oxidation,Reduction,And Rearrangement Under Nearly Neutral Conditions. The Utility Of 1 For These Reactions Is Described.
    DOI:10.1021/jo990211Q

    海关参考信息

    专利信息


    专利号:US-9597327-B2
    优先权日:2005-05-25
    标 题:Synthesis of (R)-N-methylnaltrexone
    发明人:DOSHAN HAROLD D; PEREZ JULIO
    权利人:PROGENICS PHARM INC
    摘要:This invention relates to stereoselective synthesis of R-MNTX and intermediates thereof, pharmaceutical preparations comprising R-MNTX or intermediates thereof and methods for their use.

    专利号:US-9518014-B2
    优先权日:2012-07-20
    标 题:Process for synthesis of ezetimibe and intermediates used in said process
    发明人:DING KUILING; WANG XIAOMING; WANG ZHENG
    权利人:SHANGHAI INST ORGANIC CHEMISTRY CAS
    摘要:A process for the production of ezetimibe and intermediates used in said process are disclosed. A kind of Morita-Baylis-Hillman adduct can be altered to chiral carboxylic acid derivatives of β-arylamino α-methylene with high activity and selectivity by means of ally lamination reaction, and the above carboxylic acid derivatives of β-arylamino α-methylene can be altered to the chiral intermediates of ezetimibe by means of simple conversion and further synthesized into the chiral drug ezetimibe. The synthesis route introduces chirality through the use of a chiral catalysis method, thereby avoiding the use of the chiral auxiliary oxazolidinone; and the route is economical and eco-friendly.

    专利号:US-4582903-A
    优先权日:1984-08-17
    标 题 :Synthesis of unsaturated hydantoins with an inexpensive catalyst
    发明人:MIRVISS STANLEY B
    权利人:STAUFFER CHEMICAL CO
    摘要:Alkylidene or arylidene substituted hydantoins are produced by condensation of an aromatic or aliphatic aldehyde with hydantoin in the presence of at least one basic salt of an inorganic acid. The desired products are obtained in high yields.

    专利号:US-5012000-A
    优先权日:1989-10-30
    标 题 :Total synthesis of chiral 2-amino-1,3-diols
    发明人:ILLIG CARL R; WEIS ALEXANDER L
    权利人:EASTMAN KODAK CO
    摘要:A method for the preparation of chiral 2-amino-1,3-diols is disclosed. The method involves four steps including performance of an aldol condensation with a chiral oxazolidinone on an aldehyde, treating the aldol condensation product with an alkali metal azide, treating the product with a borohydride reagent and reducing the azide to an amine.

    专利号:US-8071780-B2
    优先权日:2003-06-13
    标题:2-Hydroxymethyl-3,4,5-trihydroxy-1-benzilpiperidine derivatives as inhibitors of glucosylceramide
    发明人:ORCHARD MICHAEL GLEN
    权利人:ORCHARD MICHAEL GLEN; ACTELION PHARMACEUTICALS LTD
    摘要:The present invention provides novel piperidine derivatives of formula (I), n n n n n n n n n n n n wherein R represents a substituted benzyl group, which are useful as inhibitors of glucosylceramide synthase (GCS). The compounds of the Invention are useful for treating various glycolipid storage diseases, such as Gaucher's disease, Sandhoff's disease, Tay-Schs disease, Fabry disease, and GM1 gangliosidosis; glycolipid accumulation disorders, such as Niemann-Pick disease, mucopolysaccharidoses, mucolipidosis type IV and α-mannosidosis; various cancers that involve abnormal glycolipid synthesis; and various infectious diseases that involve cell surface glycolipids as receptors for the infectious organisms or for their toxins; as well as a variety of other disorders involving glycolipid synthesis, including neuronal disorders, inflammatory diseases, obesity, and the like.

    专利号:WO-2012173504-A2
    优先权日:2011-06-15
    标 题 :Method for synthesis of the substituted azetidinones and intermediates for their synthesis

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    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: M Jiménez, Et Al. Competitive Inhibition Of Mushroom Tyrosinase By 4-Substituted Benzaldehydes. J Agric Food Chem. 2001 Aug;49(8):4060-3.

    合成参考文献


    摘要:Spitzner, D., Science of Synthesis, (2005) 15, 13.
    摘要:Ogura, K., Science of Synthesis, (2007) 30, 466.
    摘要:Merino, P., Science of Synthesis, (2010) 45, 126.
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