CAS: 531-06-6; N'-(Furan-2-Ylmethyl)-N,N-Dimethyl-N'-Pyridin-2-Ylethane-1,2-Diamine

英文名称N'-(Furan-2-Ylmethyl)-N,N-Dimethyl-N'-Pyridin-2-Ylethane-1,2-Diamine
中文名称美沙呋林
其它别名1,2-Ethanediamine,N-(2-furanylmethyl)-N',N'-dimethyl-N-2-pyridinyl- (9CI); Pyridine, 2-[[2-(dimethylamino)ethyl]furfurylamino]-(8CI); 2-[(2-Dimethylaminoethyl)furfurylamino]pyridine; Methafurilen; Methafurylene; N,N-Dimethyl-N'-(2-pyridyl)-N'-(2-furfuryl)ethylenediamine; N,N-Dimethyl-N'-(2-pyridyl)-N'-furfurylethylenediamine; N'-(2-Furylmethyl)-N'-(2-pyridyl)-N,N-dimethylethylenediamine
CAS编号531-06-6
FDA UNII编号:HU5BZT118T
分子式:C14H19N3O分子量:245.32
产品CID: 1516498
产品分类有机原料 → 有机氮化合物

相似结构搜索
InChIKey: LUQHAHRMUPOTQK-UHFFFAOYSA-N
1S/C14H19N3O/c1-16(2)9-10-17(12-13-6-5-11-18-13)14-7-3-4-8-15-14/h3-8,11H,9-10,12H2,1-2H3
计算化学: 氢键受体数4.0氢键供体数0.0可旋转键数6.0

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合成工艺路线路线简述

📜2-(2-Furfurylideneamino)Pyridine置于lithium Amide,镍,苯体系中,化学反应生成美沙呋林
参考文献:Some Furan Antihistaminic Agents
标题:Some Furan Antihistaminic Agents
摘要:
DOI:10.1021/ja01159A037

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2921211000-乙二胺
2933310010-吡啶
2939800000-其他生物碱
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合成参考文献

参考文献:10.1016/s0022-3565(25)04313-7
摘要:ORCUTT JA, PRYTHERCH JP. PHARMACOLOGY OF N-(2-FURFURYL)-N-(2-PYRIDYL)-N',N'-DIMETHYLETHYLENEDIAMINE FUMARATE (METHAFURYLENE FUMARATE). I. ANTIHISTAMINIC PROPERTIES OF THIS COMPOUND AND ITS 5-CHLORO AND 5-BROMO DERIVATIVES. The Journal of Pharmacology and Experimental Therapeutics. 1950 Aug;99(4):479–87. doi: 10.1016/s0022-3565(25)04313-7.
参考文献:10.1016/s0022-3565(25)04315-0
摘要:ORCUTT JA, MICHAELSON SM, PRYTHERCH JP, DUPREY LP. PHARMACOLOGY OF N-(2-FURFURYL)-N-(2-PYRIDYL)-N' ,N'-,DIMETHYLETHYLENEDIAMINE FUMARATE (METHAFURYLENEFUMARATE). II. TOXICOLOGICAL STUDIES. The Journal of Pharmacology and Experimental Therapeutics. 1950 Aug;99(4):488–92. doi: 10.1016/s0022-3565(25)04315-0.
参考文献:10.1007/bf00394940
摘要:Lijinsky W, Kovatch RM. Carcinogenicity studies of some analogs of the carcinogen methapyrilene in F344 rats. Journal of Cancer Research and Clinical Oncology. 1986 Jul;112(1):57–60. doi: 10.1007/bf00394940.