CAS: 42059-81-4; 6-Methyl-4-Oxo-4H-Chromene-3-Carbaldehyde

上下游产品

5-methyl-2-hydroxyacetophenone N,N-dimethyl-formamide p-cresol 3-(1-hydroxybut-3-en-1-yl)-6-methylchromone 4,5-Diphenyl-2-(6'-methyl-4'(H)-oxo-1-benzopyran-3'-yl)-imidazol H-benzo[b]chromeno[2,3-e][1,4]diazepin-13-one2,6-dimethyl-6H-benzo[b]chromeno[2,3-e][1,4]diazepin-13-one H-benzo[b]chromeno[2,3-e][1,4]diazepin-13-one2-methyl-6-phenyl-6H-benzo[b]chromeno[2,3-e][1,4]diazepin-13-one (E)-1-(2-hydroxy-5-methylphenyl)-3-(piperidin-1-yl)prop-2-en-1-one

📜乙酸对甲酚酯置于aluminum (Iii) Chloride,草酰氯体系中,化学反应生成 6-甲基-4-氧-4H-1-苯并吡喃-3-甲醛
参考文献:新型取代的4 H-Chromen-1,2,3,4-四氢嘧啶-5-羧酸酯的合成,构效关系作为潜在的抗分枝杆菌和抗癌药
标题:新型取代的4 H-Chromen-1,2,3,4-四氢嘧啶-5-羧酸酯的合成,构效关系作为潜在的抗分枝杆菌和抗癌药
摘要:合成了一系列4 H-1,2,3,4-四氢嘧啶-5-羧甲基铬衍生物7A-7Zb,8A-8D和9A-9D并筛选了其对结核分枝杆菌h 37 Rv的体外抗分枝杆菌活性.(mtb)和针对三种人类癌细胞系(包括a549,Sk-N-Sh和hela)的细胞毒性.结果表明,六种化合物的效价更高,而7Za与标准药物乙胺丁醇和环丙沙星相比,它是最有效的抗分枝杆菌衍生物.但是,有12种化合物对人神经母细胞瘤细胞系表现出细胞毒性.其中,与标准药物阿霉素相比,化合物7V最有效.这是首次针对这种新型的4 H-Chromen-1,2,3,4-Tetrahydropyrimidine-5-Carboxylates分配体外抗分枝杆菌,抗癌和结构-活性关系的报告.
DOI:10.1016/j.Bmcl.2011.03.079

专利信息

专利号:US-7056348-B2
优先权日:2001-04-19
标题:5-aryl-1,3,3-trimethyl-2-methylene-indoline derivatives and salts thereof, methods for the production and use of said compounds for the temporary coloration of fibers
发明人：SAUTER GUIDO; BRAUN HANS-JUERGEN; REICHLIN NADIA
权利人:WELLA AG
摘要:A method for the synthesis of 5-aryl-1,3,3,-trimethyl-2-methylene-indoline derivatives of Formula (I) or its salts of Formula (Ia) wherein 1 mole of a 5-aryl-2,3,3-trimethyl-3H-indole derivative of Formula (VII) is reacted for 1 to 44 hours at a temperature of 20° to 180° C. in an apolar, aprotic or polar, protic or polar aprotic solvent with 1 to 50 moles of a compound of Formula R1-A; new compounds of Formulas (I)/(Ia) and (V), obtainable by this method as well as an agent containing at least one compound of Formula (I)/(Ia) and a carbonyl/imine compound for dyeing keratinic fibers and a method for temporarily dyeing keratin fibers, for which the keratin fiber is dyed with the aforementioned agent and the dyeing, so obtained, is removed again at any later time by a sulfite preparation.

专利号:WO-0053313-A2
优先权日:1999-03-09
标 题:Lanthanide catalysts for synthesis of compounds and combinatorial libraries

专利号:US-3984441-A
优先权日:1971-06-21
标 题:Chromonealdehyde compounds and process for the production thereof
发明人：NOHARA AKIRA; UMETANI TOMONOBU; MIYATA YOSHIBUMI; SANNO YASUSHI
权利人:TAKEDA CHEMICAL INDUSTRIES LTD
摘要:There are provided compounds of the general formula ##SPC1## n Wherein R is a hydroxy, alkyl, acyloxy, halogen, nitro, substituted or unsubstituted amino, alkoxy, carboxy or a group derived from a carboxy group and m is 0, 1 or 2 except where m is 2, the two R groups are both hydroxy groups. n The present invention is also concerned with a process for preparing the chromonealdehyde compounds. The chromonealdehyde compounds are characterized by antiallergic properties and are therefore useful as prophylactic and therapeutic agents for allergic asthma, allergic dermatitis and other allergic diseases and also are valuable as intermediates for the synthesis of other pharmaceutical compounds having the chromone nucleus.

专利号:US-2012316192-A1
优先权日:2011-06-09
标题:Substituted indolo [2,3-a] quinolizines
发明人：WALDMANN HERBERT; KUMAR KAMAL; HUEBEL KATJA; PRIES VERENA; DUECKERT HEIKO; MENNINGER SASCHA; ZIEGLER SLAVA; BRUSS HANNA; KHEDKAR VIVEK; ESCHENBRENNER VINCENT
权利人:WALDMANN HERBERT; KUMAR KAMAL; HUEBEL KATJA; PRIES VERENA; DUECKERT HEIKO; MENNINGER SASCHA; ZIEGLER SLAVA; BRUSS HANNA; KHEDKAR VIVEK; ESCHENBRENNER VINCENT
摘要:The present invention relates to novel substituted indolo[2,3-a]quinolizines and stereoisomeric forms thereof and/or pharmaceutically acceptable salts of these compounds as well as pharmaceutical compositions containing at least one of these substituted indolo[2,3-a]quinolizines together with pharmaceutically acceptable carrier, excipient and/or diluents. Said novel substituted indolo[2,3-a]quinolizines have been identified as useful for the prophylaxis and treatment of cancer by the induction of strong mitotic delays, chromosomal misalignments and mitotic tri- and multipolarization leading to cell cycle stop and apoptosis. Furthermore a synthesis for preparation of the substituted indolo[2,3-a]quinolizines is disclosed in the present invention.

专利号:CN-115819431-B
优先权日:2022-11-04
标题:Synthesis method and application of benzopyrone-fused hydroindole compounds