CAS: 381-73-7; 2,2-Difluoroacetic Acid

相似化合物

454-31-9 359-13-7 2218-52-2

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CAS号79-43-6 二氯乙酸 | CAS号471-44-3 氯氟乙酸 | CAS号116-14-3 四氟乙烯 | CAS号64-18-6 甲酸 | CAS号454-31-9 二氟乙酸乙酯 | CAS号75747-56-7 4-hydroxy-3,3'-... | CAS号354-08-5 二氟溴乙酸 | CAS号76-05-1 三氟乙酸(TFA) | CAS号2218-52-2 sodium,2,2-difl... | CAS号1069085-48-8 1-苄基-2-(二氟甲基)-4... | CAS号1069085-50-2 2-(二氟甲基)-1-苯基-4... | CAS号377-38-8 四氟丁二酸 | CAS号395-01-7 2,2-二氟苯乙酮 | CAS号354-08-5 二氟溴乙酸 | CAS号401-67-2 二氟乙酸酐 | CAS号359-13-7 2,2-二氟乙醇 | CAS号381-72-6 二氟乙酰氯 | CAS号454-31-9 二氟乙酸乙酯 | CAS号192637-90-4 S-tert-butyl 2,...

1,1-二氟乙烷置于双氧水体系中,用88%的收率获得产物二氟乙酸
参考文献:一种二氟乙酸的合成方法
标题:一种二氟乙酸的合成方法
摘要:本发明涉及一种二氟乙酸的合成方法,属于有机氟化工技术领域.本发明的二氟乙酸的合成方法,以1,1‑二氟乙烷(r152A)与过氧化氢为原料,一步制备二氟乙酸,未反应的1,1‑二氟乙烷(r152A)经回收后循环使用,目标产物的选择性和转化率高,对设备无腐蚀,安全环保.所用催化剂为固体酸催化剂,催化效率高,可反复使用,反应完成后易于与反应体系分离,尤其适合用于以1,1‑二氟乙烷(r152A)与过氧化氢为原料制备二氟乙酸.所采用的原料均为常见试剂,来源广,价格便宜,反应条件温和,反应过程易于控制.所制得的二氟乙酸产品产率较高,适合工业化生产.

专利信息

专利号:US-7294486-B2
优先权日:2001-09-05
标 题:Enzymatic process for the synthesis of organo-fluorine compounds
发明人：O'HAGAN DAVID; SCHAFFRATH CHRISTOPH
权利人:UNIV ST ANDREWS
摘要:There is described a process for the synthesis of a fluoronucleoside compound, said process comprising mixing a substrate and an enzyme from Streptomyces cattelya as catalyst. The process may be used to produce an 18 F labelled fluoronucleoside compound. There is also described an enzyme derived from Streptomyces cattelya which has the capacity to catalyse the synthesis of a fluoronucleoside compound.

专利号:US-6252105-B1
优先权日:1998-07-06
标题:Synthesis of low-fluoride organic compounds
发明人：BRAUN MAX; EICHER JOHANNES; JANSSENS FRANCINE; EICHHOLZ KERSTIN; PALSHERM STEFAN
权利人:SOLVAY FLUOR & DERIVATE
摘要:Organic compounds, e.g. fluorinated organic compounds such as fluorinated carboxylic acids or fluorinated carboxylic acid chlorides, may contain small amounts of carboxylic acid fluorides, hydrogen fluoride or hydrolyzable fluoride, which during the preparation of derivatives of the fluorinated organic compounds, for example by esterification, may yield corrosive fluorides or hydrogen fluoride. The invention is a method for the synthesis and/or purification of preferably fluorinated organic compounds such as carboxylic acids, carboxylic acid chlorides and derivatives such as esters thereof, starting from corresponding carboxylic acid chlorides containing acid fluorides or hydrolyzable fluoride, and alcohols under the catalytic action of 'onium' salts of carboxylic acids, to obtain products which have a low fluoride content. Alternatively, an inorganic oxide adsorbent is utilized. The method is especially suitable for the synthesis of esters of trifluoroacetic acid, chlorodifluoroacetic acid, trifluoroacetoacetic acid and/or difluoroacetoacetic acid.

专利号:WO-2017089470-A1
优先权日:2015-11-27
标 题:Process for the synthesis of aryldiazonium salts using nitrogen oxides in oxygen-containing gas streams, especially from industrial waste gases
发明人：HOFMANN DAGMAR; HOFMANN JOSEFA; HEINRICH MARKUS
权利人:Friedrich-Alexander-Universität Erlangen-Nürnberg
摘要:The present invention relates to a process for the synthesis of aryldiazonium salts using nitrogen oxides in oxygen-containing gas streams, especially from industrial waste gases.

专利号:US-12240835-B2
优先权日:2018-09-18
标题:Substituted benzamides as intermediates in the synthesis of inhibitors of tyrosine kinase enzymatic activity
发明人：ROMERO F ANTHONY; KIRSCHBERG THORSTEN A; HALCOMB RANDALL; XU YINGZI
权利人:TERNS PHARMACEUTICALS INC
摘要:Provided herein are compounds, preferably compounds inhibiting tyrosine kinase enzymatic activity of a protein selected from Abelson protein (ABL1), Abelson-related protein (ABL2), or a chimeric protein BCR-ABL1, compositions thereof, and methods of their preparation, and methods of inhibiting tyrosine kinase enzymatic activity of a protein selected from Abelson protein (ABL1), Abelson-related protein (ABL2), or a chimeric protein BCR-ABL1, and methods for treating diseases wherein modulation of BCR-ABL1 activity prevents, inhibits, or ameliorates the pathology and/or symptomology of the disease. Intermediates such as compounds of Formula (S23), which are useful in the synthesis of compounds inhibiting tyrosine kinase enzymatic activity of a protein selected from Abelson protein (ABL1), Abelson-related protein (ABL2), or a chimeric protein BCR-ABL1, are also provided.

专利号:US-2013338369-A1
优先权日:2011-03-07
标 题 :Process for the Synthesis of Aminobiphenylene
发明人：HEINRICH MARKUS; PRATSCH GERALD
权利人:HEINRICH MARKUS; PRATSCH GERALD; BASF SE
摘要:The present invention relates to a process for the synthesis of 2-aminobiphenylene and derivatives thereof by reacting a benzene diazonium salt with an aniline compound under basic reaction conditions.

专利号:US-2015099864-A1
优先权日:2013-10-08
标题:Preparation of organophosphate peptide adducts
发明人：BREWER BOBBY N; LUCAS ERIC A; BURKITT NATHAN T
权利人:BATTELLE MEMORIAL INSTITUTE
摘要:Disclosed are methods for the synthesis of organophosphorus-adducted peptides. Such peptides may be useful as biomarkers of organophosphate exposure, or for the synthesis of antibodies. Also disclosed are peptide adducts including peptide adducts of tabun, and aged adducts.