CAS: 253-72-5; 1,6-Naphthyridine

该化合物是一种环环状结构装有两个氮原子的环状结构的七环有机化合物,这种双环芳烃系统因其在医药化学和材料科学中作为多用途建筑块的作用而备受重视,其僵硬的脚手架和丰富的电子性质使它适合设计药品,特别是在发展动脉抑制剂和抗微生物剂方面.该化合物参与氢联结和-浸泡相互作用的能力增强了其在超分子化学和协调综合体中的效用.1,6-Naphthyridine衍生物由于其具有金枪鱼光物理特性,还被探索用于可视电子应用.高纯度能确保合成和研究应用的一贯性.

结构式图片

相似化合物

23616-33-3 72754-06-4 944804-84-6

欧盟法规

ECHA物质C&L通报

上下游产品

1,2,3,4-tetrahydro-1,6-naphthyridine 5-hydrazinyl-1,6-naphthyridine 6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl acetate 2-(trimethylsilylethynyl)pyridine-3-carboxaldehyde 1,2,3,4-tetrahydro-1,6-naphthyridine [5-(1H-Indol-3-yl)-5H-[1,6]naphthyridin-6-yl]-phenyl-methanone cyclopropanaphthyridine1a,1b,2,7b-tetrahydro-1,2-bis(phenylsulfonyl)-1H-azirino1.2-acyclopropa1.6naphthyridine 2-amino-1,6-naphthyridine

合成工艺路线路线简述

    2-溴-3-吡啶甲醛置于bis-Triphenylphosphine-Palladium(II) Chloride,Copper(L) Iodide 氨,三乙胺体系中,用 乙醇,N,N-二甲基甲酰胺 用作溶剂,化学反应 3.5H,反应生成1,6-二氮萘
    参考文献:General Synthetic Method For Naphthyridines And Their N-Oxides Containing Isoquinolinic Nitrogen
    标题:General Synthetic Method For Naphthyridines And Their N-Oxides Containing Isoquinolinic Nitrogen
    摘要:通过o-乙炔基吡啶甲醛与氨的反应,合成了含有异喹啉氮的取代萘啶.通过相应的肟,这些吡啶衍生物的n-氧化物也通过基本的环化反应得到合成.
    Doi:10.1055/s-1999-3379

    海关参考信息

    专利信息


    专利号:US-9273023-B2
    优先权日:2011-11-01
    标 题:Modular synthesis of graphene nanoribbons and graphene substructures from oligo-alkynes
    发明人:ALABUGIN IGOR; BYERS PHILIP M
    权利人:UNIV FLORIDA STATE RES FOUND
    摘要:A method for the synthesis of carbon-based structures, particularly graphene substructures and ribbons, from oligo- and poly-alkyne starting materials.

    专利号:US-9403841-B2
    优先权日:2012-01-25
    标题:Phragamalin limonoids for the treatment of sexual dysfunction
    发明人:WIKBERG JARL; JIRGENSONS AIGARS; LIEPINSH EDVARDS
    权利人:DICOTYLEDON AB
    摘要:The present invention relates to novel chemical compounds, to methods for synthesis of such compounds, and to the use of these novel compounds in the synthesis of other chemical compounds that, inter alia, may be used in the treatment of sexual dysfunction, and for eliciting enhancing effects on sexual behavior. The invention also relates to remarkable biological properties of the novel compounds in their capacity of inducing aggressive behavior.

    专利号:US-11485721-B2
    优先权日:2017-11-21
    标 题:Method for the metal-free preparation of a biaryl by a photosplicing reaction and their uses
    发明人:KLOSS FLORIAN; NEUWIRTH TONI; HAENSCH VEIT; HERTWECK CHRISTIAN
    权利人:LEIBNIZ INST FUER NATURSTOFF FORSCHUNG UND INFEKTIONSBIOLOGIE E V HANS KNOELL INST HKI; LEIBNIZ INST FUER NATURSTOFF FORSCHUNG UND INFEKTIONSBIOLOGIE E V HANS KNOELL INST
    摘要:The present invention relates to a method for the metal-free preparation of a biaryl compound by a photosplicing reaction and its use in the preparation of chemical compounds, preferably of active ingredients e.g. in the fields of pharmaceuticals and agrochemicals. In particular, it refers to a method for the regiocontrolled preparation of a biaryl compound of formula (I): Ar—Ar′ by photochemically reacting a precursor compound of formula (II): Ar—L—Ar′ to form a biaryl compound of general formula: Ar—L—Ar′(II)→Ar—Ar′ (I) wherein Ar and Ar′, independently of each other, represent an unsubstituted or substituted C6-C20 aryl group or a heteroaryl group with 5-20 ring atoms selected from carbon, nitrogen, oxygen and sulfur, and L represents a group —X—Y—Z— as defined herein. The biaryl compounds are generally suitable as intermediates or key building blocks in a very broad spectrum of organic chemical syntheses and their respective utilities. Their use within the field of synthesis of active ingredients is an aspect of the invention, and their use in the preparation of pharmaceutically active ingredients is particularly preferred.

    专利号:US-2006009510-A1
    优先权日:2004-07-09
    标 题 :Method of synthesizing indolinone compounds
    发明人:HAVENS JEFFREY L; VAIDYANATHAN RAJAPPA
    权利人:PHARMACIA & UPJOHN CO LLC
    摘要:Disclosed are methods of preparing pyrrole compounds of formula 14 and indolinone compounds of formula 1 n nvia a synthetic route wherein the amide sidechain on the pyrrole moiety is attached prior to pyrrole formation. The compounds 14 produced by the methods herein are useful in the synthesis of compounds of formula 1, which are useful in the treatment of abnormal cell growth, such as cancer.

    专利号:WO-2008012852-A1
    优先权日:2006-07-27
    标 题:Intermediate compounds for the preparation of angiotensin ii antagonists
    发明人:GUANDALINI LUCA; MARTINI ELISABETTA; ROMANELLI MARIA NOVELLA; DALLATOMASINA FRANCO
    权利人:S I M S S R L SOC IT MEDICINAL; GUANDALINI LUCA; MARTINI ELISABETTA; ROMANELLI MARIA NOVELLA; DALLATOMASINA FRANCO
    摘要:The present invention relates to novel substituted biphenyltetrazole compounds useful as intermediates in the preparation of angiotensin II antagonists, to a process for the synthesis of them and to a process for the conversion thereof to said molecules.

    专利号:US-7429555-B2
    优先权日:2004-04-30
    标 题:Lubricating grease with high water resistance
    发明人:SCHERER MARKUS; FISCHER MATTHIAS; MUELLER MICHAEL; KINKER BERNARD; PAUKER ALEXANDRA
    权利人:ROHMAX ADDITIVES GMBH
    摘要:The present invention relates to lubricating greases comprising at least one thickening agent and at least one lubricating oil, wherein the lubricating grease contains at least one polymeric structure improver that can be obtained by polymerization of monomer compositions, which are composed ofn a) 0 to 40 wt %, relative to the weight of the monomer compositions for synthesis of the polymeric structure improvers, of at least one (meth)acrylate of formula (I) nn nin which R represents hydrogen or methyl, R 1 denotes a straight-chain or branched alkyl moiety having 1 to 5 carbon atoms,n b) 40 to 99.99 wt %, relative to the weight of the monomer compositions for synthesis of the polymeric structure improvers, of at least one (meth)acrylate of formula (II) n nin which R represents hydrogen or methyl, R 2 denotes a straight-chain or branched alkyl moiety having 6 to 30 carbon atoms,n c) 0.01 to 20 wt %, relative to the weight of the monomer compositions for synthesis of the polymeric structure improvers, of monomers containing acid groups or salts thereof, d) 0 to 59.99 wt %, relative to the weight of the monomer compositions for synthesis of the polymeric structure improvers, of comonomer.
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    合成参考文献


    摘要:Snaith, J. S., Science of Synthesis Knowledge Updates, (2011) 2, 185.
    摘要:Walker, J. C. L., Science of Synthesis: Knowledge Updates, (2024) 3, 201.
    参考文献:10.1107/s1600536810030576
    摘要:Vennila KN, Prabha K, Manoj M, Prasad KJR, Velmurugan D. 7-(2-Chlorophenyl)-2,6,9-trimethyldibenzo[b,h][1,6]naphthyridine. Acta Crystallogr E Struct Rep Online. 2010 Aug 28;66(9):o2426–7. doi: 10.1107/s1600536810030576.
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