CAS: 227947-06-0; 3-(4-(2-(4-(3-Chloro-2-Hydroxypropoxy)Phenyl)Propan-2-yl)Phenoxy)Propane-1,2-Diol

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18H22O4C18H22O4 3-[4-[1-[4-(2,3-dihydroxypropoxy)phenyl]-1-methylethyl]phenoxy]propane-1,2-diol 1-chloro-3-[4-[2-[4-(3-chloro-2-hydroxypropoxy)phenyl] propan-2-yl]phenoxy]propan-2-ol

📜双酚 A 二(3-氯-2-羟丙基)醚置于sodium Hydroxide体系中,用 丙二醇甲醚,水 用作溶剂,化学反应 2.5H,反应生成双酚a(3-氯-2-羟丙基)甘油醚,2-Chloro-3-[4-[2-[4-(Oxiran-2-Ylmethoxy)Phenyl]Propan-2-Yl]Phenoxy]Propan-1-Ol,[1-Chloro-3-[4-[2-[4-(Oxiran-2-Ylmethoxy)Phenyl]Propan-2-Yl]Phenoxy]Propan-2-Yl] Acetate,[2-Hydroxy-3-[4-[2-[4-(Oxiran-2-Ylmethoxy)Phenyl]Propan-2-Yl]Phenoxy]Propyl] Acetate,3-[2-Hydroxy-3-[4-[2-[4-(Oxiran-2-Ylmethoxy)Phenyl]Propan-2-Yl]Phenoxy]Propoxy]Propane-1,2-Diol,3-[4-[1-[4-(3-氯-2-羟基丙氧基)苯基]-1-甲基乙基]苯氧基]-1,2-丙二醇,,2,2-双-(4-甘胺氧苯)丙烷,双酚 A (2,3-二羟基丙基)缩水甘油醚
参考文献:Process For Manufacturing An Alpha-Dihydroxy Derivative And Epoxy Resins Prepared Therefrom
标题:Process For Manufacturing An Alpha-Dihydroxy Derivative And Epoxy Resins Prepared Therefrom
摘要:从芳基烯丙基醚制备α-二羟基衍生物的制造过程,其中该α-二羟基衍生物可用于制备α-卤代醇中间体和由此制备的环氧树脂,包括在氧化剂存在下或在氧化剂和催化剂存在下通过卤代物取代从α-二羟基衍生物脱氢反应中获得的α-卤代醇中间体的环氧化.

专利信息

专利号:US-2022118123-A1
优先权日:2019-02-22
标 题 :Combination of ar antagonists and targeted thorium conjugates
发明人：HAMMER STEFANIE; HAGEMANN URS BEAT; HAENDLER BERNARD; LEJEUNE PASCALE; ZITZMANN-KOLBE SABINE; SCHATZ CHRISTOPH; KARLSSON JENNY
权利人:BAYER AG; BAYER AS
摘要:The present invention covers combinations of at least two components, component A and component B, comprising component A being PSMA-TTC, and component B being an antiandrogen selected form AR antagonists such as from cyproterone acetate, bicalutamide, flutamide, nilutamide, enzalutamide, apalutamide, darolutamide or keto-darolutamide, or an AR degrader such as ARV-110, or an ARN-terminal domain binder such as EPI-506, or an antisense oligonucleotide that reduces AR expression such as EZN-4176 or AZD-5312, or an androgen synthesis inhibitor such as abiraterone, particularly abiraterone acetate, seviteronel, galeterone, orteronel or ketoconazole, or a dual AR antagonist and androgen synthesis inhibitor such as ODM-204. Another aspect of the present invention covers the use of such combinations as described herein for the preparation of a medicament for the treatment or prophylaxis of a disease, particularly for the treatment of a hyper-proliferative disease.