CAS: 1971920-73-6; (R)-1-(1-Acryloylpiperidin-3-yl)-4-Amino-3-(4-Phenoxyphenyl)-1H-Imidazo[4,5-C]Pyridin-2(3H)-One
- 英文名称(R)-1-(1-Acryloylpiperidin-3-yl)-4-Amino-3-(4-Phenoxyphenyl)-1H-Imidazo[4,5-C]Pyridin-2(3H)-One
- 中文名称(R)-1-(1-丙烯酰基哌啶-3-基)-4-氨基-3-(4-苯氧基苯基)-1H-咪唑并[4,5-C]吡啶-2(3H)-酮
- IUPAC名称(R)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one
- 其它别名2H-Imidazo(4,5-C)Pyridin-2-One, 4-Amino-1,3-Dihydro-1-((3R)-1-(1-Oxo-2-Propen-1-yl)-3-Piperidinyl)-3-(4-Phenoxyphenyl)-; 8Cz82Zyy9X; 4-Amino-3-(4-Phenoxyphenyl)-1-[(3R)-1-(Prop-2-Enoy
- CAS编号1971920-73-6
- MFCD编号:MFCD32710277
- FDA UNII编号:8CZ82ZYY9X
- 分子式:C26H25N5O3分子量:455.52
- 产品CID: 1004412
- 产品分类医药中间体 → 吡啶类化合物
物理性质
MSDS等安全信息
合成工艺路线路线简述
📜Tert-Butyl (R)-3-((3-Amino-2-(Bis(4-Methoxybenzyl)-Amino)Pyridin-4-yl)Amino)Piperidine-1-Carboxylate置于2,2,6,6-四甲基哌啶氧化物,氧气,Copper Diacetate,三乙胺,三氟乙酸体系中,用 甲醇,二氯甲烷,乙腈 用作溶剂,化学反应 7.08H,反应生成(R)-1-(1-丙烯酰基哌啶-3-基)-4-氨基-3-(4-苯氧基苯基)-1H-咪唑并[4,5-C]吡啶-2(3H)-酮
参考文献: Tyrosine Kinase Inhibitors[fr] Inhibiteurs De La Tyrosine Kinase
标题: Tyrosine Kinase Inhibitors[fr] Inhibiteurs De La Tyrosine Kinase
摘要:本公开提供了一些酪氨酸激酶抑制剂化合物,特别是布鲁顿酪氨酸激酶("Btk")抑制剂,因此适用于治疗通过抑制btk可治疗的疾病,如癌症,自身免疫性疾病,炎症性疾病和血栓栓塞性疾病.还提供了含有这些化合物的药物组合物以及制备这些化合物的方法.
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2912110000-甲醛
2912120000-乙醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-2025101021-A1
优先权日:2022-06-14
标 题:Methods of making tolebrutinib
发明人：BAILLY FRÉDÉRIC; BENELLI CHRISTOPHE; BORIE CYRIL; BOSCH MICHAËL; CABOS CLAUDE; CHARAUDEAU ALEXIS; JANSSENS LAURENCE; PACQUET FRANÇOIS; RODIER FABIEN; SALLÉ LAURENT; SODO ALFRED; VIGNE SYLVIE
权利人:PRINCIPIA BIOPHARMA INC
摘要:Disclosed herein are improved synthetic routes for making (R)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1 H-imidazo[4,5-c]pyridin-2(3H)-one (tolebrutinbib). Also disclosed herein are novel compounds used in the synthesis of of (R)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1 H-imidazo[4,5-c]pyridin-2(3H)-one.
专利号:US-2025282777-A1
优先权日:2024-03-06
标 题:Methods of Making Tolebrutinib
发明人：BALTES DAVID; BOHORC BOJAN; SAKHAII PEYMAN
权利人:PRINCIPIA BIOPHARMA INC
摘要:Disclosed herein are improved synthetic routes for making (R)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1H-imidazo[4,5-c]pyridin-2(3H)-one (tolebrutinib). Also disclosed herein are novel compounds used in the synthesis of (R)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1H-imidazo[4,5-c]pyridin-2(3H)-one.
