CAS: 193978-23-3; 4,4,5,5-Tetramethyl-2-(2-Thienyl)-1,3,2-Dioxaborolane

在 氯化铵体系中,用 四氢呋喃 用作溶剂,以92 %的收率获得噻吩-2-硼酸频哪醇酯
参考文献:C−s 键激活促进室温无水 Suzuki-Miyaura 聚合
标题:C−s 键激活促进室温无水 Suzuki-Miyaura 聚合
摘要:探索了(杂)芳基硼酸酯和芳基硫醚之间的无水室温 Cas-Suzuki-Miyaura 交叉偶联反应,其通用性以 30 种小分子和 12 种交替共轭聚合物为例.机理研究揭示了室温和无水条件在减少自偶联缺陷和增强共轭聚合物光电性能方面的重要性.
Doi:10.1002/anie.202309922

专利信息

专利号:US-12076715-B1
优先权日:2021-04-15
标 题:Synthesis and characterization of air-stable iron-based catalysts for Suzuki-Miyaura cross-coupling reactions of alkyl halides and aryl boronic esters
发明人：WONG ALEXANDER; BYERS JEFFERY
权利人:THE TRUSTEES OF BOSTON COLLEGE
摘要:This disclosure relates to novel catalysts for Suzuki-Miyaura cross-coupling reactions, the use thereof, and the methods of making the same.

专利号:US-9243004-B2
优先权日:2011-07-22
标题 :Synthesis of boronic esters and boronic acids using grignard reagents
发明人：CLARY JACOB W; SINGARAM BAKTHAN
权利人:CLARY JACOB W; SINGARAM BAKTHAN; UNIV CALIFORNIA
摘要:Boronic esters and boronic acids are synthesized at ambient temperature in an ethereal solvent by the reaction of Grignard reagents with a boron-containing substrate. The boron-containing substrate may be a boronic ester such as pinacolborane, neopentylglycolborane, or a dialkylaminoborane compound such as diisopropylaminoborane. The Grignard reagents may be pre-formed or generated from an alkyl, alkenyl, aryl, arylalkyl, heteroaryl, vinyl, or allyl halide compound and Mg 0 . When the boron-containing substrate is a boronic ester, the reactions generally proceed at room temperature without added base in about 1 to 3 hours to form a boronic ester compound. When the boron-containing substrate is a dialkylaminoborane compound, the reactions generally proceed to completion at 0° C. in about 1 hour to form a boronic acid compound.

专利号:US-9074050-B2
优先权日:2011-05-30
标 题 :Process for the production of polymers by using coupling reactions
发明人：KLEINER MATTHIAS; ELBS MARTIN; KASTLER MARCEL
权利人:KLEINER MATTHIAS; ELBS MARTIN; KASTLER MARCEL; BASF SE
摘要:The present invention relates to a continuous process for the production of polymeric coupling products by using a reactor assembly which is equipped with two or more reaction cells. The educt fluid is pumped through the reaction cells and thoroughly mixed therein by means of agitators. Preferably the process according to the invention is used for the preparation of coupling products which show at least partially precipitation and/or gelation effects during the performance of the synthesis. The precipitation and/or gelation effects are associated with and increase of the viscosity of the reaction system under reaction conditions. The products which are obtained by the process according to the invention have increased molecular weight and low polydispersity over similar products which were obtained in batch experiments.

专利号:US-7122694-B2
优先权日:1998-11-06
标 题 :Hydroboronation process
发明人：MARCUCCIO SEBASTIAN MARIO; RODOPOULOS MARY; WEIGOLD HELMUT
权利人:BORON MOLECULAR PTY LTD
摘要:The invention relates to processes for the synthesis of aryl or alkene borates which comprises reacting: (i) an olefinic compound having a halogen or halogen-like substituent in a vinylic substitution position, or (ii) an aromatic ring having a halogen or halogen-like substituent in a ring substitution position, with a disubstituted monohydroborane in the presence of a Group 8-11 metal catalyst. The invention also relates to the use of these borates in coupling reactions. The invention further relates to certain disubstituted monohydroboranes and aryl or alkene borates.

专利号:WO-2013016185-A1
优先权日:2011-07-22
标 题 :Synthesis of boronic esters and boronic acids using grignard reagents

专利号:WO-2022162606-A1
优先权日:2021-01-30
标 题:Heterocyclic compounds as kinase inhibitor and uses thereof
发明人：YAN ZHIYU; WANG XIAOHUI; LIU HANLAN; KHAN PASHA M; PANPATIL DAYANAND; PUJALA BRAHMAM; PENDHARKAR DHANANJAY; JADHAVAR PRADEEP S; SAEED UZMA; KUMAR VIVEK
权利人:SPEROGENIX THERAPEUTICS LTD; INTEGRAL BIOSCIENCES PRIVATE LTD
摘要:The present disclosure relates generally to compounds useful in treatment of conditions associated with Checkpoint kinase (CHK), particularly CHK-1 enzymes. Specifically, the present invention discloses compound of formula (J), which exhibits inhibitory activity against CHK-1 enzymes. Methods of treating conditions associated with excessive activity of CHK-1 enzymes such as cancer, idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH) with such compounds is disclosed. Uses thereof, pharmaceutical compositions, kits and method of synthesis also disclosed. Formula (J)