专利号:US-4709034-A 优先权日:1986-02-14 标 题 :Process for the synthesis of hydroxyalkyl amines and hydroxyalkyl piperazines 发明人:MARSELLA JOHN A 权利人:AIR PROD & CHEM 摘要:The present invention comprises a process for the synthesis of hydroxyalkyl amines, hydroxyalkyl piperazines, or alkyl piperazines from alkylene glycols and ammonia or alkyl amines using a substantially soluble transition metal carbonyl complex catalyst precursor.
专利号:US-4092316-A 优先权日:1975-02-03 标题:Synthesis of C-alkyl-triethylenediamines 发明人:NIEH EDWARD C Y 权利人:TEXACO DEVELOPMENT CORP 摘要:A liquid phase synthesis of C-alkyl-triethylenediamines involves heating to elevated temperatures of from about 200° C to 300° C a suitable N-(2-hydroxyalkyl) piperazine feedstock in the presence of a catalytic amount of a pentavalent acidic phosphorus compound and then recovering the C-alkyl-triethylenediamine product from the resulting reaction product mixture.
专利号:US-7126025-B2 优先权日:2003-01-21 标 题 :Synthesis of 4-(amino)-2-butenoyl chlorides and their use in the preparation of 3-cyano quinolines 发明人:CONSIDINE JOHN LEO; DAIGNEAULT SYLVAIN; CHEW WARREN; IERA SILVIO; DUNCAN SCOTT MASON; REN JIANXIN 权利人:WYETH CORP 摘要:This invention provides a compound of Formula (I): n nwhereinn S 1 and S 2 are each independently, hydrogen, alkyl, alkenyl, alkynyl, aralkyl, substituted or unsubstituted aryl, and S 1 and S 2 together with the nitrogen to which they are attached form a nitrogen containing heteroaryl and a pharmaceutically acceptable salt thereof; a method of preparing the compound of Formula (I), and use of the compound of Formula (I) in the preparation of 3-cyano quinolines.
专利号:US-7902295-B2 优先权日:2004-08-05 标 题 :Single step synthesis of functional multi-block polymer 发明人:BOERNER PETER W; GRAVES DANIEL; HALL JAMES E; ICEMAN BRENT 权利人:FIRESTONE POLYMERS LLC 摘要:The inventive composition includes a block copolymer which includes four blocks and has the following block arrangement: B-S-B-S. The two polymer blocks B comprise conjugated diene monomer constitutional units; and the two polymer blocks S comprise vinyl aromatic hydrocarbon monomer constitutional units. The invention also includes methods of making such inventive compositions as well as asphalt compositions and/or thermoplastic elastomers which include such block copolymer.
专利号:WO-2021224280-A1 优先权日:2020-05-05 标题:Synthesis of a sickle cell disease agent and intermediates thereof 发明人:JUDGE THOMAS; SCHROEDER MEL C; KOPEL LUCAS C; EKLOV BRIAN M 权利人:DIPHARMA FRANCIS SRL 摘要:New processes for preparing 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5- yl)pyridin-3-yl)methoxy)benzaldehyde, an agent developed for the treatment of sickle cell disease, and intermediates thereof, are provided herein.
专利号:US-4537713-A 优先权日:1981-05-29 标题 :Process for the reduction of reducible groups and its use 发明人:ECKERT HEINER 权利人:ECKERT HEINER 摘要:The invention concerns a process for the reduction of groups containing unsaturated C,C-, C,N-,N,N-,N,O- bonds, especially of NO2-,NO-,NOH-,NR-,CN-,N3-,N2-groups or C=C or C-halogen- or acyl groups with hydrogen on MPc or with a suitable reduction agent on [MPc](-), whereby a platinum metal-phthalocyanine is used as the catalyst. It is possible that by the reversible change (control) of the oxidation phase z of the platinum metal from z>/=2 to z=1 using the same MPc complex, basically different reductions can be selectively catalysed. Thus the invention concerns a process for selective reduction using platinum metal-phthalocyanine catalysts with reaction specificity in three different reaction patterns. The inventive process is suitable, especially for the synthesis of alpha -phenylalkylamines, benzylalkylamines, N-alkyl-amino carboxylic acids, alpha -hydroxycarboxylic acids, peptides, N-heterocyclic compounds as well as generally in the field of pharmaceutical, herbicide and insecticide production.
参考文献:10.1007/s00216-011-5206-x 摘要:Gadzała-Kopciuch R, Cendrowski K, Cesarz A, Kiełbasa P, Buszewski B. Determination of zearalenone and its metabolites in endometrial cancer by coupled separation techniques. Analytical and Bioanalytical Chemistry. 2011 Jul 13;401(7):2069. doi: 10.1007/s00216-011-5206-x.