专利号:US-11944609-B1 优先权日:2023-06-16 标题:Antifungal ionic liquid and Amphotericin B combination 发明人:RATHER SAMI-ULLAH; WANI MOHMMAD YOUNUS; BAMUFLEH HISHAM S; ALHUMADE HESHAM; SAEED USMAN; TAIMOOR AQEEL AHMAD; ALALAYAH WALID M; RATHER IRFAN AHMAD 权利人:KING ABDULAZIZ UNIVERISTY; UNIV KING ABDULAZIZ 摘要:Provided herein are ionic liquids that can be used as antifungal agents alone or in combination with Amphotericin B. Also disclosed are methods of synthesis of the ionic liquids and inhibiting fungal growth and methods of treating fungal infections using the disclosed compounds. The disclosure provides antifungal agents that potentiate the antifungal activity of Amphotericin B, a commonly used antifungal drug that could be used alone or in combination. This combination will help control and combat the infections caused by drug resistant Candida. auris in immunocompromised patients.
专利号:WO-2020123881-A1 优先权日:2018-12-12 标题:Boron containing compounds and their uses 发明人:LIU CHUN YU; ZHOU YASHEEN; YANG STEPHEN; LIU CBUNLIANG; ZHANG YONG-KANG 权利人:BORAGEN INC 摘要:The present disclosure relates to boron-containing compounds, novel combiantions, and novel uses. The disclosure provides novel benzoxaborole compounds, pharmaceutical compositions, and associated methods of use. In particular, modeling suggests the benzoxaborole compounds disclosed herein are useful for inhibiting protein prenylation or ergosterol synthesis in a pathogenic microorganism. The benzoxaborole compounds according to the disclosure are further useful for the treatment of infectious microorganisms including pathogenic fungi and protozoan parasites, such as those that cause malaria.
专利号:RU-2189982-C2 优先权日:1997-03-31 标题:Azole compounds, method of their synthesis, antifungal pharmaceutical composition and method of treatment of fungal infection
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合成参考文献
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