CAS: 1003048-72-3; 4-Bromo-7-Fluoro-2,3-Dihydro-1H-Inden-1-One

相似化合物

881189-73-7 1242157-14-7 1260012-83-6

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CAS号651735-59-0 7-氟-1-茚满酮

📜7-氟-1-茚满酮置于aluminum (III) Chloride,溴体系中,用 1,2-二氯乙烷 用作溶剂,化学反应 2.0H,反应生成4-溴7-氟茚酮
参考文献: Substituted Dihydroindene-4-Carboxamides And Analogs Thereof,And Methods Using Same[fr] Dihydroindène-4-Carboxamides Substitués,Leurs Analogues Et Procédés D'Utilisation Correspondant
标题: Substituted Dihydroindene-4-Carboxamides And Analogs Thereof,And Methods Using Same[fr] Dihydroindène-4-Carboxamides Substitués,Leurs Analogues Et Procédés D'Utilisation Correspondant
摘要:本发明包括新颖的取代双环化合物,以及包含这些化合物的组合物,可用于治疗或预防患者体内的乙型肝炎病毒(hbv)感染.在某些实施例中,本发明的化合物和组合物是壳蛋白抑制剂.(化学式i)

专利信息

专利号:US-8633182-B2
优先权日:2012-05-30
标题:Indanyloxyphenylcyclopropanecarboxylic acids
发明人：HAMPRECHT DIETER; FRATTINI SARA; LINGARD IAIN; PETERS STEFAN
权利人:HAMPRECHT DIETER; FRATTINI SARA; LINGARD IAIN; PETERS STEFAN; BOEHRINGER INGELHEIM INT
摘要:The present invention relates to compounds of general formula I, n nwherein the groups R 1 , R 2 , R 3 , m and n are defined as in claim 1 , which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2. Furthermore, the invention relates to novel intermediates, useful for the synthesis of compounds of formula I.

专利号:US-9051289-B2
优先权日:2013-09-26
标 题 :Process and intermediates for preparing GPR40 agonists
发明人：DAHMANN GEORG; WAGNER HOLGER; ECKHARDT MATTHIAS; FRANK MARKUS; SANTAGOSTINO MARCO; SCHNAUBELT JUERGEN; STERTZ UWE; PACHUR THORSTEN
权利人:DAHMANN GEORG; WAGNER HOLGER; ECKHARDT MATTHIAS; FRANK MARKUS; SANTAGOSTINO MARCO; SCHNAUBELT JUERGEN; STERTZ UWE; PACHUR THORSTEN; BOEHRINGER INGELHEIM INT
摘要:The present invention relates to compounds of formula I n nwherein R S denotes F or CF 3 , R a denotes H or C 1-4 -alkyl and Z denotes a leaving group or an optionally substituted or protected hydroxyl group, suitable as intermediates in the synthesis of indanyloxydihydrobenzofuranylacetic acids, which are GPR40 agonists, to a process for preparing these intermediates and to the process for preparing the GPR40 agonists making use of an asymmetric catalytic hydrogenation reaction in the presence of a transition metal catalyst and a chiral auxiliary.

专利号:US-9308194-B2
优先权日:2013-11-28
标 题:Indanyloxyphenylcyclopropanecarboxylic acids
发明人：LINGARD IAIN; HAMPRECHT DIETER
权利人:BOEHRINGER INGELHEIM INT
摘要:A compound of formula I, n nwherein the groups R 1 , R 2 , R 3 , X, m, and n are defined as in claim 1 , which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2. Furthermore, the invention relates to novel intermediates, useful for the synthesis of compounds of formula I.