CAS: 938-96-5; 2-(4-Hydroxyphenyl)Propionic Acid
该化合物是一种含有分子配方C9H10O3的酚类衍生物.该化合物的特点是一个碳信箱组和一个附属于一个苯环的氢氧基组,使其成为有机合成和制药应用的多种中间体.该化合物因其在生产非类苯抗炎药物和其他生物活性分子中作为前体的作用而特别受到重视.该化合物在极地溶剂中表现出良好的稳定性和溶解性,便于其在各种化学反应中使用.其结构特性还有助于研究酶过程和代谢途径.为研究和工业应用提供了高纯度的等级.
- 英文名称2-(4-Hydroxyphenyl)Propionic Acid
- 中文名称2-(4-羟基苯基)丙酸
- IUPAC名称2-(4-hydroxyphenyl)propanoic acid
- 其它别名Hydratropicacid, p-hydroxy- (6CI,7CI,8CI); 2-(4-Hydroxyphenyl)propanoic acid; 2-(4-Hydroxyphenyl)propionic acid; 2-(p-Hydroxyphenyl)-propionic acid; Methyl4-hydroxyphenylacetic acid
- CAS编号938-96-5
- MFCD编号:MFCD00128847
- EINECS号:213-352-7
- FDA UNII编号:55FH3476SI
- 分子式:C9H10O3分子量:166.17
- 产品CID: 1982050
- 产品分类有机原料→分子砌块→芳环类化合物→苯类化合物
- 相似结构搜索
- 产品信息参考
;;;; - InChIKey: ZHMMPVANGNPCBW-UHFFFAOYNA-N
- InChI=1/C9H10O3/c1-6(9(11)12)7-2-4-8(10)5-3-7/h2-6,10H,1H3,(H,11,12)
- 计算化学: 氢键受体数2.0氢键供体数2.0可旋转键数2.0
物理性质
MSDS等安全信息
欧盟法规
ECHA物质C&L通报REACH预注册上下游产品
2-(4-methoxyphenyl)propanoic acid 2-(4-hydroxyphenyl)propanenitrile 1-(4-hydroxyphenyl)ethanol 1-(4-methoxyphenyl)ethanone methyl 2-(4-hydroxyphenyl)propanoate 3,5-Diiodo-4-hydroxyphenylpropionic acid O-desmethylangolensin methyl 2-{4-[(methylsulfonyl)oxy]phenyl}propanoate合成工艺路线路线简述
- 合成目标产物 2-(4-Hydroxyphenyl)Propionic Acid 主要起始原料 4-Hydroxyphenylacetic Acid
- 68735-72-8 = 938-96-5 [标题:Reaction Conditions
标题:Synthesis Of Arylacetic And 2-Arylpropionic Acids By Electrocarboxylation Of Benzylic Compounds Bearing A Leaving Group Other Than A Halogen
作者:Gal,J.; Folest,J. C.; Troupel,M.; Moingeon,M. O.; Chaussard,J.
参考文献:New Journal Of Chemistry 日期:1995 卷标:19(4) 页码:401-7]
492-37-5 = 938-96-5 [标题:Reaction Conditions
标题:Fermentative Manufacture Of 2-(P-Hydroxyphenyl)Propionic Acid
参考文献:Japan]
63-91-2 = 938-96-5 [标题:Reaction Conditions
标题:Stereoselective Determination Of L-Amino Acids Using Column Liquid Chromatography With An Enzymic Solid-Phase Reactor And Chemiluminescence Detection
作者:Jansen,H.; Brinkman,U. A. T.; Frei,R. W.
参考文献:Journal Of Chromatography 日期:1988 卷标:440 页码:217-23]
= 938-96-5 [标题:Reaction Conditions
标题:α-Hydroxyarylalkanoic Acids
参考文献:European Patent Organization]
= 938-96-5 [标题:Reaction Conditions
标题:4-(α-Alkyl-α-Cyanomethyl)-2,6-Disubstituted Phenols
参考文献:United States]
= 938-96-5 [标题:Reaction Conditions
标题:2-(4-Hydroxyphenyl)Propionic Acid
参考文献:Japan]
= 938-96-5 [标题:Reaction Conditions
标题:Phenylalkanoic Acids And Derivatives Of Benzoxazole Therefrom
参考文献:European Patent Organization]
= 938-96-5 [标题:Reaction Conditions
标题:Effect Of Some Aromatic-Aliphatic Acids On The Inhibition Of Denaturation Of Serum Albumin And Stabilization Of Erythrocyte Membranes. Quantitative Relations Between Structure And Biological Activity
作者:Kuchar,M.; Brunova,B.; Roubal,Z.; Nemecek,O.
参考文献:Cesko-Slovenska Farmacie 日期:1976 卷标:25(3-4) 页码:105-12]
= 938-96-5 [标题:Reaction Conditions
标题:α-Substituted Phenylacetic Acids Prepared By The Willgerodt-Kindler Reaction
作者:Moreau,Robert; Durand-Henchoz,Simone
参考文献:Comptes Rendus Des Seances De L'Academie Des Sciences 日期:1970 卷标:271(14) 页码:862-4]
942-54-1 = 938-96-5
反应条件:1.1 Reagents: Boron Tribromide Solvents: Dichloromethane; 0.3 H,-65 °C; -65 °C -> Rt; 2.5 H,Rt
标题:Antileukotrienic Phenethylamido Derivatives Of Arylalkanoic Acids In The Treatment Of Ulcerative Colitis
作者:Junek,Richard; Kverka,Miloslav; Jandera,Antonin; Panajotova,Vladimira; Satinsky,Dalibor; Et Al
参考文献:European Journal Of Medicinal Chemistry 日期:2009 卷标:44(1) 页码:332-344]
492-37-5 = 938-96-5 [标题:Reaction Conditions
标题:Microbial Hydroxylation Of 2-Phenylpropionic Acid
作者:Kuge,Yukihiro; Mochida,Kenichi; Uwajima,Takayuki
参考文献:Agricultural And Biological Chemistry 日期:1991 卷标:55(4) 页码:1099-104]
59430-62-5 = 938-96-5 [标题:Reaction Conditions
标题:α-Methylated Analogs Of Triiodothyroalkanoic Acids: Synthesis And Biological Activity
作者:Zenker,N.; Ekpe,A. E.; Hubbard,L. S.
参考文献:Journal Of Medicinal Chemistry 日期:1992 卷标:35(3) 页码:548-52]
= 938-96-5 [标题:Reaction Conditions
标题:Identification And Profiling Of A Novel Diazaspiro[3.4]Octane Chemical Series Active Against Multiple Stages Of The Human Malaria Parasite Plasmodium Falciparum And Optimization Efforts
作者:Le Manach,Claire; Dam,Jean; Woodland,John G.; Kaur,Gurminder; Khonde,Lutete P.; Et Al
参考文献:Journal Of Medicinal Chemistry 日期:2021 卷标:64(4) 页码:2291-2309]
= 938-96-5 [标题:Reaction Conditions
标题:2-Arylpropionic Cxc Chemokine Receptor 1 (Cxcr1) Ligands As Novel Noncompetitive Cxcl8 Inhibitors
作者:Allegretti,Marcello; Bertini,Riccardo; Cesta,Maria Candida; Bizzarri,Cinzia; Di Bitondo,Rosa; Et Al
参考文献:Journal Of Medicinal Chemistry 日期:2005 卷标:48(13) 页码:4312-4331]
= 938-96-5 [标题:Reaction Conditions
标题:α-Arylalkanoic Acid Derivatives
参考文献:European Patent Organization]
= 938-96-5 [标题:Reaction Conditions
标题:Phenylacetic And Thienylacetic Acids.
参考文献:European Patent Organization]
= 938-96-5 [标题:Reaction Conditions
标题:Substituted 4,10-Dihydro-10-Oxothienobenzoxepins And Intermediates And Their Use As Medicaments
参考文献:European Patent Organization]
= 938-96-5 [标题:Reaction Conditions
标题:Phenylalkanoic Acids
参考文献:United States]
= 938-96-5 [标题:Reaction Conditions
标题:The Synthesis Of Arylpropionic Acids And The Quantitative Relationship Between The Structure And The Activation Of Fibrinolysis
作者:Kuchar,Miroslav; Brunova,Bohumila; Rejholec,Vaclav; Roubal,Zdenek; Nemecek,Oldrich
参考文献:Collection Of Czechoslovak Chemical Communications 日期:1981 卷标:46(5) 页码:1173-87
📜对羟基苯乙酸置于硫酸体系中,用 甲醇,Silica Gel,甲苯 作为反应溶剂,以80%的收率获得产物2-(4-羟基苯)丙酸
参考文献:Method For Treatment Or Prophylaxis Of Cardiac Disorders
标题:Method For Treatment Or Prophylaxis Of Cardiac Disorders
摘要:一种用于治疗哺乳动物心脏疾病的预防的方法,包括向该类哺乳动物施用以下式的短效β-阻滞化合物:##str1## 其中r可以是较低的烷基,芳基或芳基烷基;n可以是从0到约10的整数;x可以是从1到3的整数;ar可以是取代或未取代的芳香基;r.Sub.1可以是较低的烷基或芳基烷基;以及其药学上可接受的盐.还公开了具有短效β-肾上腺素能阻滞活性的新化合物.
海关参考信息
- 2902600000-乙苯
2902700000-异丙基苯
2905121000-正丙醇
2912110000-甲醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-9453037-B2
优先权日:2011-07-28
标 题 :Methylphenidate-prodrugs, processes of making and using the same
发明人：GUENTHER SVEN; CHI GUOCHEN; BERA BINDU; MICKLE TRAVIS; BERA SANJIB
权利人:KEMPHARM INC; KEMPHARM INC
摘要:The present technology is directed to prodrugs and compositions for the treatment of various diseases and/or disorders comprising methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof. In some embodiments, the conjugates further include at least one linker. The present technology also relates to the synthesis of methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof or combinations thereof.
专利号:US-8716532-B2
优先权日:2009-03-27
标 题:One pot multicomponent synthesis of some novel hydroxy stilbene derivatives with alpha, beta-carbonyl conjugation under microwave irradiation
发明人：SHARMA ABHISHEK; SINHA ARUN KUMAR; KUMAR RAKESH; SHARMA NAINA
权利人:SHARMA ABHISHEK; SINHA ARUN KUMAR; KUMAR RAKESH; SHARMA NAINA; COUNCIL SCIENT IND RES
摘要:The present invention provides a method for the preparation of some novel multiconjugated 2- or 4-hydroxy substituted stilbenes. The method provides one pot multicomponent approach wherein 3-4 step reaction sequences viz. condensation, decarboxylation and Heck coupling occur simultaneously which results in an enhanced yield of desired products and reduced reaction times.
专利号:US-2023046065-A1
优先权日:2019-11-25
标题 :MERGING C(sp3)-H ACTIVATION WITH DNA-ENCODING
发明人：YU JIN-QUAN
权利人:SCRIPPS RESEARCH INST
摘要:Palladium-catalyzed C(sp3)—H arylation of aliphatic carboxylic acids, amides and ketones with BNA-encoded aryl iodides in water is disclosed, Furthermore, sequential C—H arylation chemistry enabled the on-DNA synthesis of structurally-diverse scaffolds containing enriched C(sp3) character, chiral centers, cyclopropane, cyclobutane, and heterocycles. That new chemistry permits preparation of a DNA—encoded library (BEL) technology that can dramatically expedite hit identification in drug discovery owing to its ability to perform protein affinity selection with millions or billions of molecules in a single experiment. The sequential functionalization of multiple C—H bonds provides an unique avenue for creating diversity and complexity from simple starting materials. The use of water as solvent, the presence of DMA, and the extremely low concentration of DMA-encoded coupling partners (0.001 M) have previously hampered the development DMA-encoded C(sp3)—H activation reactions, but many of those hurdles have now been overcome.
专利号:ES-2379925-A1
优先权日:2010-10-06
标 题:PROCEDURE FOR THE SYNTHESIS OF LACTONES DERIVED FROM THE PROPIONIC P-HYDROXYPHYL ACID.
专利号:ES-2379925-B1
优先权日:2010-10-06
标 题 :PROCEDURE FOR THE SYNTHESIS OF LACTONES DERIVED FROM PROPIONIC P-HYDROXYPHYL ACID
专利号:US-2016326157-A1
优先权日:2014-01-06
标 题:Monobactams and methods of their synthesis and use
发明人：MYERS ANDREW G; Seiple lan Bass; SUSSMAN ROBIN JUDITH
权利人:HARVARD COLLEGE
摘要:Described herein are monobactam antibiotics of Formula (I), (I′), (II), and (II′), along with methods and intermediates for preparing these compounds. Pharmaceutical compositions and methods of treating infectious diseases using the monobactams are also provided.
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合成参考文献
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参考文献:10.1016/s0378-1097(02)00458-5|10.1111/j.1574-6968.2002.tb11081.x
摘要:Schoefer L, Mohan R, Braune A, Birringer M, Blaut M. Anaerobic C-ring cleavage of genistein and daidzein by Eubacterium ramulus. FEMS Microbiol Lett. 2002 Mar 05;208(2):197–202. doi: 10.1111/j.1574-6968.2002.tb11081.x.
参考文献:10.1007/s00216-004-2682-2
摘要:Steinkamp T, Karst U. Detection strategies for bioassays based on luminescent lanthanide complexes and signal amplification. Analytical and Bioanalytical Chemistry. 2004 Aug 05;380(1):24–30. doi: 10.1007/s00216-004-2682-2.
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