CAS: 933-90-4; 3-Hydroxypicolinamide

该化合物是一种由皮氏酸衍生物(与尼古丁酸有关)产生的结构相关化合物,它作为各种生物化学途径和具有picoxime功能反应的中间或前体,其主要优势在于它与尼基丁胺里叶赛德(NR)和尼基丁酸衍生物在结构上相似,有可能使其在新陈代谢或细胞信号路径所涉的特定酶系统中充当基质或调节器.该化合物由于其氢氧化物组和picoxime modie而具有独特的再活动性,它提供了不同于类似皮科林胺本身的其他相关亚胺的具体功能,其确切优势在很大程度上取决于其应用的具体生物化学环境.

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932-35-4 194665-89-9 574705-02-5

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上下游产品

CAS号73406-50-5 3-羟基吡啶甲酸乙酯 | CAS号874-24-8 3-羟基-2-吡啶甲酸 | CAS号38180-46-0 3-氯-2-氰吡啶 | CAS号60832-72-6 2,3-二氢吡啶并[2,3-d... | CAS号16867-03-1 2-氨基-3-羟基吡啶

合成工艺路线路线简述

  • 874-24-8 = 933-90-4
    反应条件:1.1 Reagents: Ammonia
    标题:Ammonolysis Of 3-Hydroxypicolinic Acids. A Correction And Illustration Of The Use Of Carbon-13 Nmr Oh/od Isotope Shifts
    作者:Moore,George G. I.; Kirk,Alan R.; Newmark,Richard A.
    参考文献:Journal Of Heterocyclic Chemistry 日期:1979 卷标:16(4) 页码:789-91]

    = 933-90-4 [标题:Reaction Conditions
    标题:Preparation Of Picolinic Acid Derivatives
    参考文献:Switzerland]

    874-24-8 = 933-90-4
    反应条件:1.1 Reagents: Urea Catalysts: Zirconium Oxychloride Octahydrate; 60 S,80 °C
    标题:Zirconyl Chloride-Promoted Highly Efficient Solid Phase Synthesis Of Amide Derivatives
    作者:Reddy,Cherkupally Sanjeeva; Nagaraj,Adki; Jalapathi,Pochampally
    参考文献:Chinese Chemical Letters 日期:2007 卷标:18(10) 页码:1213-1217]

    = 933-90-4 [标题:Reaction Conditions
    标题:Preparation Of Quaternary 3-Hydroxypyridinium Chlorides
    作者:Petersen,John Brammer; Norris,Kjeld; Clauson-Kaas,Niels; Svanholt,Karen
    参考文献:Acta Chemica Scandinavica (1947-1973) 日期:1969 卷标:23(5) 页码:1785-90
📜3-羟基吡啶甲酸乙酯置于氨体系中,化学反应生成 3-羟基吡啶酰胺
参考文献:Arnold Et Al.,Journal Of The Chemical Society,1958,P. 4466,4468
标题:Arnold Et Al.,Journal Of The Chemical Society,1958,P. 4466,4468

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专利信息


专利号:US-8735586-B2
优先权日:2007-06-26
标 题 :Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles
发明人：ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÉ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR
权利人:ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÉ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR; SANOFI SA
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, n nwherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct copper catalyzed regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.

专利号:EP-2173747-B1
优先权日:2007-06-26
标 题:A regioselective metal catalyzed synthesis of annelated benzimidazoles and azabenzimidazoles
发明人：ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARE MARC; R KYEN OMAR; URMANN MATHIAS; HALLAND NIS
权利人:SANOFI SA
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, wherein R1; R2; R3; R4; J1; J2; J3; J4 and G have the meanings indicated in the claims. The present invention provides a direct metal, e.g. palladium or copper, catalyzed, regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.

专利号:US-2010261909-A1
优先权日:2007-06-26
标题 :Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles

专利号:WO-2009000413-A1
优先权日:2007-06-26
标题:A regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles

专利号:CA-2693142-A1
优先权日:2007-06-26
标题:A regioselective metal catalyzed synthesis of annelated benzimidazoles and azabenzimidazoles

专利号:AU-2008267444-A1
优先权日:2007-06-26
标 题 :A regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles

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主要参考文献

[参考文献]: K Clays, Et Al. A Fluorescence Lifetime Study Of Virginiamycin S Using Multifrequency Phase Fluorometry. Biochemistry. 1991 Jul 23;30(29):7271-6.

合成参考文献


参考文献:10.1007/s10895-011-0846-y
摘要:Rosa ILV, de Sousa Filho PC, Neri CR, Serra OA, de Figueiredo AT, Varela JA, Longo E. Synthesis and Study of the Photophysical Properties of a New Eu3+ Complex with 3-Hydroxypicolinamide. Journal of Fluorescence. 2011 Jan 28;21(4):1575–83. doi: 10.1007/s10895-011-0846-y.
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